Area of general research interest:
Cell-matrix interactions in the repair of connective tissues, particularly knee joint cartilage and meniscus.
Current program:
- Characterization of the meniscus fibrochondrocyte, a cell that can efficiently repair its matrix
- The role of the pericellular matrix in maintenance of tissue homeostrasis
- Definition of the cellular and molecular mechanisms involved in the degeneration of cartilage in hemorrhage and iron overload into joints
- The role of isoforms of type VI collagen, a cell-matrix bridging protein, in repair of connective tissue
Investigators:
- McDevitt, Cahir A., M.Phil., Ph.D.
- Chakrabarti, Amitabha, Ph.D.
- Klika, Alison K., M.S.
- Johnson, Cory L., B.S.
- Feeback, Kevin, B.S.
Collaborators:
- Andrish, Jack, M.D., Dept. of Orthopaedic Surgery, CCF
- Davis, Brian L., Ph.D., Dept. of Biomedical Engineering, CCF
- Fleming, Braden, Ph.D., Dept. of Orthopaedics, Brown Medical School,
Providence, RI
- Matyas, J., Ph.D., McCaig Center for Joint Injury and Arthritis Research,
University of Calgary
- Mort, John S., Ph.D., Joint Diseases Laboratory & Department of
Surgery, Shriners Hospital for Children, McGill University, Montreal,
Quebec, Canada
- Penn, Marc, M.D., Ph.D., Dept. of Cardiology, CCF
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