Yan Xu, Ph.D. | Research | Publications

Key Publications

Xu Y , Gaudette DC, Boynton J, Frankel A, Fang X-J, Sharma A, Hurteau J, Casey G, Goodbody AE, Mellors A, Holub BJ Mills G.   Characterization of an Ovarian Cancer Activating Factor (OCAF) in Ascites from Ovarian Cancer Patients. Clinical Cancer Res. 1, 1223-1232. 1995.

Xu Y, Fang X-J, Casey G, Mills G. Lysophospholipids activate ovarian and breast cancer cells. Biochem J. 309, 933-940. 1995.

Xu Y, Shen Z, Wiper DW, Wu M, Morton RE, Elson P, Kennedy AW, Belinson, J, Markman M, Casey G. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers . JAMA 280, 719-723, 1998.

Xu Y , Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Yj, Damron DS. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol. 2, 261-267, 2000.

Zhu, K., Baudhuin, L., Hong, G. Williams, F.S., Cristina, K.L., Kabarowski, J.H.S., Witte, O.N. and Xu, Y Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein coupled receptor, GRP4. J Biol Chem . 276(44):41325-41335, 2001.

Xiao Y, Schwartz B, Washington M, Kennedy A, Webster K, Belinson J. and Xu Y . Electrospray Ionization Mass Spectrometry Analysis of Lysophospholipids in Human Ascitic Fluids: Comparison of the Lysophospholipid Contents in Malignant vs. Non-malignant Ascitic Fluids. Anal Biochem. 290, 302-313, 2001.

Xu Y, Xiao, Y, Baudhuin LM, Schwartz BM.   The role and clinical applications of bioactive lysolipids in ovarian cancer.   J. Soc. Gyn. Invest 8,1-13, 2001.

Baudhuin LM, Kristina KL, Lu, J, and Xu Y . Activation induced by LPA and S1P requires both MEK and p38 MAP kinase and is cell-line specific . Mol Pharmacol 62, 660-671, 2002.

Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein coupled receptors and receptor-mediated signal transduction. Biochem Biophy Acta 1582 81-88, 2002.

Lauber K, Bohn E, Krober SM, Xiao Y, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G, Wesselborg S. Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal.   Cell . 113, 717-730, 2003.

Sengupta S, Xiao YJ, Xu Y. A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells. FASEB J . 17, 1570-1572. 2003.

Xu Y, Xiao Y, Zhu K, Baudhuin LM, Lu J, Hong G, Kim KS, Cristina KL, Song L, Williams FS, Elson P, Markman M, and Belinson J. Unfolding the pathophysiological role of bioactive lysophospholipids. Current drug targets-immune, endocrine & metabolic disorders ,   3, 23-32, 2003.

Sutphen R, Xu Y , Wilbanks GD, Fiorica J, Grendys EC Jr, LaPolla JP, Arango H, Hoffman MS, Martino M, Wakeley K, Griffin D, Blanco RW, Cantor AB, Xiao YJ, Krischer JP. Lysophospholipids are potential biomarkers of ovarian cancer. Cancer Epidemiol Biomarkers , (13) 1185-1191, 2004.

Baudhuin LM, Jiang, Y, Alexander Zaslavsky, Ishii I, Chun J, and Xu Y. S1P 3 -mediated Akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR). FASEB J . express article 10.1096/fj.03-0302fje. Published online Dec. 4, 2003. Printed in paper vol 18, 341-343, 2004.

Sengupta S, Wang Z, Tipps R and Xu Y . Biology of LPA in healthy and disease, Seminars in Cell and Developmental Biology , 15, 503-512, 2004.

Xiao Y and Xu Y , Analysis of Lysophospholipids in Human Body Fluids: Comparison of the Lysophospholipid Contents in Malignant vs. Non-malignant Diseases. Functional Lipidomics.   Marcel Dekker, Inc., New York, in press, 2005.

Kwan-sik Kim, Juan Ren, Ying Jiang, Quteba Ebrahem, Russell Tipps, Kelly Cristina, Yi-jin Xiao, Jing Qiao, Lum Hazel, Bela Anand-Apte, and Yan Xu GPR4 plays a critical role in endothelial cell and mediates the effects of sphingosylphosphorylcholine. FASEB J. , in press, 2005.