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Henry F. Hoff, Ph.D.
Consultant

Department of Cell Biology
Lerner Research Institute / NC10
9500 Euclid Avenue
Cleveland, Ohio 44195
hoffh@ccf.org

 

  Area of general research interest:
  • Role of lipoproteins in atherogenesis and pathogenesis of age-related macular degeneration.
  • Mechanisms responsible for formation of lipid-protein cross-links in cells that have internalized oxidized LDL.
  • Cellular recognition of novel epitopes formed on LDL during oxidation.
  • Oxidation of LDL by reactive nitrogen species: a physiologically-relevant modification with atherogenic properties.
  • Mechanisms responsible for the poor degradation of rod outer segments by the retinal pigment epithelium following treatment with oxidized lipids.

 

Collaborators:

  • Podrez, Evgeny, M.D., Ph.D.
    • Department of Cell Biology, Cleveland Clinic
  • Lawrence Sayre, Ph.D.
    • Department of Chemistry, Case Western Reserve University
  • Robert Salomon, Ph.D.
    • Department of Chemistry, Case Western Reserve University
  • Stanley Hazen, M.D., Ph.D.
    • Department of Cell Biology and Department of Cardiology, Cleveland Clinic
  • John Crabb, Ph.D.
    • Department of Ophthalmology, Cleveland Clinic
  • Alan Marmorstein, Ph.D.
    • Department of Ophthalmology, Cleveland Clinic

Key References:

Podrez EA, O'Neil, J, Salomon RG, Schreiber MJ, Hoff HF. Measurement of oxidation in plasma LDL and Lp(a) in patients with end-stage renal disease undergoing CAPD using an ELISA employing antibodies to LGE2- protein adducts. Kidney Int. 54, 637-645, 1998.

Podrez EA, Schmitt D, Hoff HF, Hazen SL. The myeloperoxidase-H2O2-NO2- system of monocytes converts low density lipoprotein into a form which promotes macrophage cholesterol accumulation and foam cell formation. J. Clin Invest. 103, 1547-1560, 1999.

Salomon RG, Sha W, Brame C, Kaur K, Subbanagounder G, O'Neil J, Hoff HF, Roberts LJ , Protein adducts of iso(4) levuglandin E2, a product of the isoprostane pathway in oxidized low density lipoprotein. J. Biol. Chem. 274, 20271-20280, 1999.

Hazen SL, Zhang Z, Wu W, Podrez EA, MacPherson JC, Schmitt D, Mitra SN, Mukhopadhyay C, Chen Y, Cohen P, Hoff HF, Abu-Soud HM. Formation of nitric oxide-derived myeloperoxidase in monocytes: Pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo. Circ.Res. 85, 950-958, 1999 .

Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein R, Hajjar DP, Cohen P, Frazier WA, Hoff HF, Hazen SL. The macrophage scavenger receptor CD36 is the major pathway for LDL recognition following modification by monocyte-generated reactive nitrogen. J.Clin. Invest. 2000 (in press).

Febbraio M., Podrez EA, Smith JD, Hazen SL, Hoff HF, Sharma K, Hajjar DP, Silverstein RL Targeted Disruption of the Class B Scavenger Receptor, CD36, Protects Against Atherosclerotic Lesion Development in Mice. J Clin Invest. 2000 (in press)

Podrez EA, Hoppe G, O'Neil J, Sayre, LM, Sheibani N, Hoff HF. Macrophage receptors responsible for distinct recognition of LDL containing pyrrole or pyridinium adducts: models of oxidized LDL. J.Lipid Res. 2000 (revised received)