Paul L Fox, Ph.D.

Staff

Robert Canova Endowed Chair in Inflammation Research

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NC1-103
foxp@ccf.org
Phone: (216) 444-8053
Fax: (216) 444-9404



We have discovered a novel translational control pathway that selectively regulates inflammatory gene expression in myeloid cells, and may be an endogenous regulator of the duration and magnitude of the inflammatory response. IFN-gamma induces expression of certain pro-inflammatory mRNAs, e.g., vascular endothelial growth factor (VEGF)-A and ceruloplasmin, but synthesis of the proteins is limited by translational silencing. IFN-gamma induces assembly of the 4-protein, IFN-Gamma-Activated Inhibitor of Translation (GAIT) complex, that binds a specific RNA element in the 3’untranslated region of target mRNAs, and inhibits translation. We are investigating the signal transduction pathways that lead to activation of the GAIT system, the mechanisms by which two of the proteins escape their parent complexes, and the in vivo function of the pathway. Also, we are taking a ribonomic approach to elucidate the family of targets silenced by this pathway. In other major projects in the laboratory, we investigate the molecular mechanisms that regulate endothelial cell polarization and movement, a critical and initiating event in the formation of new blood vessels and in repair of injured vessels. We also study the role of ferroxidases in cellular and whole-body iron metabolism, and particularly their role in inflammatory diseases and chronic renal failure.


Abul  Arif Ph.D.
Abul Arif Ph.D.
Project Staff

Location:NC1-105
Phone:(216) 444-1214
arifaa@ccf.org
Fax:(216) 444-9404
laboratory

Arnab  China PhD
Arnab China PhD
Postdoctoral Fellow

Location:NC1-104
Phone:(216) 444-1214
chinaa@ccf.org
Fax:(216) 444-9404
laboratory

Prabar Kumar  Ghosh PhD
Prabar Kumar Ghosh PhD
Research Associate

Location:NC1-104
Phone:(216) 444-1229
ghoshp@ccf.org
Fax:(216) 444-1229
laboratory

Dalia  Halawani PhD
Dalia Halawani PhD
Postdoctoral Fellow

Location:NC1-105
Phone:(216) 444-1214
halawad@ccf.org
Fax:(216) 444-9404
laboratory

Caroline  Hall
Caroline Hall
Research Student

Location:NC1-105
Phone:(216) 444-1214
hallc3@ccf.org
Fax:(216) 444-9404
laboratory

Jie  Jia Ph.D.
Jie Jia Ph.D.
Research Associate

Location:NC1-104
Phone:(216) 444-1214
jiaj@ccf.org
Fax:(216) 444-9404
laboratory

Debjit  Khan PhD
Debjit Khan PhD
Fellow

Location:NC1-104
Phone:(216) 444-1229
khand@ccf.org
Fax:(216) 444-9404
laboratory

Krishnendu  Khan PhD
Krishnendu Khan PhD
Fellow

Location:NC1-104
Phone:(216) 444-1214
khank3@ccf.org
Fax:(216) 444-9404
laboratory

Vasu  Komireddy PhD
Vasu Komireddy PhD
Fellow

Location:NC1-105
Phone:(216) 444-1214
KOMMIRV@ccf.org
Fax:(216) 444-9404
laboratory

Hannah  Niehaus
Hannah Niehaus
Research Student

Location:NC1-105
Phone:(216) 444-1214
niehauh@ccf.org
Fax:(216) 444-9404
laboratory

Iyappan  Ramachandiran PhD
Iyappan Ramachandiran PhD
Fellow

Location:NC1-105
Phone:(216) 444-1229
ramachi@ccf.org
Fax:(216) 444-9404
laboratory

Jessica  Sacks
Jessica Sacks
Graduate Student

Location:NC1-105
Phone:(216) 444-1214
sacksj@ccf.org
Fax:(216) 444-9404
laboratory

Ilaria  Tamagno Ph.D.
Ilaria Tamagno Ph.D.
Fellow

Location:NC1-105
Phone:(216) 444-1214
tamagni@ccf.org
Fax:(216) 444-9404
laboratory

Jennifer  Taylor
Jennifer Taylor
Research Student

Location:NC1-105
Phone:(216) 444-1214
taylorj16@ccf.org
Fax:(216) 444-9404
laboratory

Fulvia  Terenzi PhD
Fulvia Terenzi PhD
Research Associate

Location:NC1-105
Phone:(216) 445-3871
terenzf@ccf.org
Fax:(216) 444-9404
laboratory

Hannah  Todorowski
Hannah Todorowski
Research Student

Location:NC1-105
Phone:(216) 444-1214
todoroh@ccf.org
Fax:(216) 444-9404
laboratory

Bravina  Trovato
Bravina Trovato
Graduate Student

Location:NC1-104
Phone:(216) 444-1229
trovatb@ccf.org
Fax:(216) 444-9404
laboratory

Peng  Yao PhD
Peng Yao PhD
Research Associate

Location:NC1-104
Phone:(216) 444-1229
yaop@ccf.org
Fax:(216) 444-9404
laboratory


Ray PS, Jia J, Yao P, Majumder M, Hatzoglou M, Fox PL. A stress-responsive RNA switch regulates VEGFA expression. Nature 457:915-919, 2009.

Yao P, Potdar AA, Arif A, Ray PS, Mukhopadhyay R, Willard B, Xu Y, Yan J, Saidel GM, Fox PL. Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 149:88-100, 2012.

Jia J, Arif A, Willard B, Smith J, Stuehr DJ, Hazen SL, Fox PL Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Mol Cell 47:656-663, 2012.

Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL. Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol 14:1046-1056, 2012.