Byron Lee, MD, PhD

Joint Staff

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NC1-141
leeb4@ccf.org
Phone: (216) 445-7515
Fax: (216) 444-9404



Bladder cancer is the fifth most common malignancy diagnosed in the United States; however, few new treatment options have been approved by the FDA for the last several decades. Molecular characterization data from The Cancer Genome Atlas and other groups demonstrate that almost all urothelial carcinomas of the bladder harbor a chromatin modifier gene mutation. Our lab is focused on understanding the effects of chromatin modifier mutations on the initiation and progression of urothelial cancers of the bladder and upper tract. We are also examining how gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK-RAS-RAF and PI3K-AKT-MTOR to influence therapeutic response and resistance.

In other words ...

I am a urologic oncologist and surgeon-scientist focused on using modern scientific tools to improve the management of urothelial cancers of the bladder and upper tract. Chromatin modifiers control how DNA is organized inside a cell's nucleus, and they are mutated in the majority of urothelial cancers. Mutations in these genes can substantially alter a cell's behavior. We are investigating how chromatin modifier mutations act to promote urothelial cancer development and potentially render these cancers susceptible to novel drug combinations.


Daniel  Kim
Daniel Kim
Research Technician

Location:NC1-140
Phone:(216) 444-9342
kimd5@ccf.org
Fax:(216) 444-9404
laboratory

Varna  Thayaparan
Varna Thayaparan
Research Student

Location:NC1-140
Phone:(216) 444-9342
thayapv@ccf.org
Fax:(216) 444-9404
laboratory