Xianquan Zhan, M.D., Ph.D.

Project Staff

Department of Ophthalmic Research, Cole Eye Institute

Telephone: (216) 445-0424

Fax : (216) 445-3670

Email: zhanx@ccf.org

ACADEMIC AND PROFESSIONAL TRAINING:

M.D., B.S.	1994, West China University of Medical Sciences, China- Preventive Medicine
M.S.	1996, West China University of Medical Sciences, China- Occupational epidemiology
Ph.D.	1999, West China University of Medical Sciences, China- Molecular toxicology
Postdoctoral Fellow	2001, Cancer Research Institute, Hunan Medical University, Changsha, Hunan, China – Oncology and Proteomics
Postdoctoral Fellow	2005, The Charles B. Stout Neuroscience Mass Spectrometry Laboratory, Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA – Proteomics and Mass Spectrometry

PROFESSIONAL EXPERIENCE:

2000-2001	Research Assistant Professor, Cancer Research Institute, Hunan Medical University, Changsha, Hunan, China
2005-2006	Assistant Professor (non-tenure track), Department of Neurology, University of Tennessee Health Science Center, Memphis, TN
2006-Present	Project Staff, Department of Ophthalmic Research, Cole Eye Institute, The Cleveland Clinic, Cleveland, OH

MEMBERSHIPS:

Human Proteome Organization (HUPO)

The Society of Neuroscience (SfN)

American Society for Mass Spectrometry (ASMS)

PUBLICATIONS:

Zhan,X. , Desiderio, D. M. (2006) Linear ion-trap mass spectrometric characterization of human pituitary nitrotyrosine-containing proteins. International Journal of Mass Spectrometry, in press .

Zhan, X , Desiderio, D. M. (2006) Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Analytical Biochemistry, 354: 279-289.

Moreno , C. S., Evans, C. O., Zhan, X. , Okor, M., Desiderio, D. M., Oyesiku, N. M. (2005) Novel molecular signaling in human clinically non-functional pituitary adenomas identified by gene expression profiling and proetomic analyses. Cancer Research, 65: 10214-10222.

Zhan, X. , Desiderio, D. M. (2005) Proteomics analysis of growth hormone isoforms in the human pituitary. Proteomics, 5: 1228-1241.

Zhan, X. , Desiderio, D. M. (2005) Comparative proteomics analysis of human pituitary adenomas: Current status and future perspectives. Mass Spectrom Reviews, 24: 783-813.

Zhan, X. , Desiderio, D. M. (2004) The human pituitary nitroproteome. Detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry. Biochem Biophys Res Commun, 325: 1180-1186.

Yang, F., He, Z. M., Zhan, X. , Chen, Z. C., Yan, B., Huang, H. K., Li, T. B. (2004) Construction and identification of directional cDNA library from Chinese giant salamander Andrias davidianus liver. Acta Zoologica Sinica, 50: 475-478.

Zhan, X. , Evans, C.-O., Oyesiku, N. M., Desiderio, D. M. (2003) Proteomics and tanscriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. Pituitary, 6: 189-202.

Li, C., Chen, Z., Xiao, Z., Wu, X., Zhan, X. , Zhang, X., Li, M., Li, J., Feng, X., Liang, S., Chen, P., Xie, J. (2003) Comparative proteomics analysis of human lung squamous carcinoma. Biochem Biophys Res Commun, 309: 253-260.

Zhan, X. , Desiderio, D. M. (2003) Heterogeneity analysis of the human pituitary proteome. Clinical Chemistry, 49: 1740-1751.

Li, C., Zhan, X. Q. , Li, M. Y., Wu, X. Y., Li, F., Li, J.L, Xiao, Z. Q., Chen, Z. C., et al. (2003) Proteomic comparison of two-dimension gel electrophoresis profiles from human lung squamous carcinoma and normal bronchial tissues. Genomics, Proteomics & Bioinformatics, 1: 51-56.

Zhan, X. , Desiderio, D. M. (2003) A reference map of a pituitary adenoma proteome. Proteomics, 3: 699-713.

Desiderio, D. M, Zhan, X. (2003) A study of the human pituitary proteome: The characterization of differentially expressed proteins in an adenoma compared to a control. Cellular & Molecular biology, 49: 689-712.

Zhan, X. , Desiderio, D. M. (2003) Spot volume vs. amount of protein loaded onto a gel. A detailed, statistical comparison of two gel electrophoresis systems. Electrophoresis, 24: 1818-1833.

Zhan, X. , Desiderio, D. M. (2003) Differences in the spatial and quantitative reproducibility between two second-dimensional gel electrophoresis systems. Electrophoresis, 24: 1834-1846.

Zhan, X. Q. , Guan, Y. J., Li, C., Chen, Z. C., et al. (2002) Differential proteomic analysis of human lung adenocarcinoma cell line A-549 and of normal cell line HBE. Acta Biochemica et Biophysica Sinica, 34: 50-56.

Zhan, X. Q. , Chen, Z. C., Li, C., et al. (2001) Analysis of human lung squamous carcinoma cell line NCI-H520 proteome by two-dimensional polyacrylamide gel electrophoresis and MALDI-TOF-mass spectrometry. Chinese Journal of Cancer, 20: 575-582.

ABSTRACTS

Desiderio, D.M., Zhan, X. The characterization of differentially expressed proteins in human pituitary adenomas compared to controls. 2003 ASMS Conference ( Montreal , Canada ).

Zhan, X., Desiderio, D.M. Heterogeneity analysis of the human pituitary proteome. 2003 Annual Oak Ridge Conference on "Brainstorming for Clinical Laboratories: New Approaches to Diagnosing neurological Diseases" ( Washington D.C. ).

Zhan, X., Desiderio, D.M. An analysis of human pituitary proteome micro-heterogeneity. 2004 ASMS Conference ( Nashville , Tennessee ).

Zhan, X. , Desiderio, D.M. Secretagogin down-regulation in human non-functional pituitary adenomas identified by proteomics and tanscriptomics analyses. 2004 University Tennessee Cancer Institute Research Day ( Memphis , Tennessee ).