Genomic Medicine Institute News: 2012

May 2012

Joanne Ngeow received an American Society of Clinical Oncology (ASCO) Merit Award and platform presentation for the Annual ASCO Meeting, held June 1st-6th in Chicago.

Abstract: Ngeow J, He X, Mester J, Radhakrishnan D, Lei J, Romigh T, Milas M, Eng C. Lowered PTEN protein dosage predicts for underlying germline mutations amongst patients presenting with thyroid cancer and Cowden-like phenotypes. Proc Am Soc Clin Oncol 2012

Joanne Ngeow was also awarded a scholarship provided by the March of Dimes to attend the 53rd Annual Short Course on Medical and Experimental Mammalian Genetics.

March 2012

Presentations at major symposia on hereditary cancer
Charis Eng, MD, PhD, Chair, GMI, was invited to co-chair and speak at the Mechanisms of Hereditary Cancer: Beyond the Tumor Suppressor Paradigm symposium of the American Association for Cancer Research (AACR) 2012 Annual Meeting, which was held March 31-April 4 in Chicago, IL.

Dr. Eng addressed the symposium with a presentation on Germline epimutations: More than the genome.She also gave an invited presentation at the "Single gene causes of cancer" session of the 2012 American College of Medical Genetics (ACMG) Annual Clinical Genetics Meeting, which was held March 27-31 in Charlotte, NC. Her talk, PTEN heritable cancer syndromes, was one of the session's four presentations. In it, she described her laboratory's research that revealed for the first time the component cancers and lifetime risks of PTEN heritable cancer syndromes, based on over 3,000 prospectively accrued patients. She emphasized that this will help tailor surveillance, including when to start, and confirmed that this has already progressed to clinical care.

Research Trainees reap rewards from AACR
Yu Wang, PhD, Eng lab, GMI was honored as an invited speaker for the "Functional Identification and Characterization of New Cancer Genes" minisymposim at the American Association for Cancer Research (AACR) 2012 Annual Meeting, which was held March 31-April 4 in Chicago, IL. Dr. Wang presented "KLLN, which shares a bidirectional promoter with PTEN, is an AR-regulated tumor suppressor, and induces p53-dependent and -independent apoptosis in breast cancer (Yu Wang, Xin He and Charis Eng)." He was commended for his presentation by winning the AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award .

Ying Ni is a Molecular Medicine PhD Program student in the Eng lab, GMI, who presented a poster, "alpha-Tocopherol protects cells from lipid peroxidation and rescues tumorigenic phenotypes in CS/CSL patients with germline SDHx variants (Ying Ni and Charis Eng)" at the American Association for Cancer Research (AACR) 2012 Annual Meeting, which was held March 31-April 4 in Chicago, IL. Ying Ni won the AACR-Women in Cancer Research (WICR) Scholar-in-Training Award for her outstanding presentation.