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Ephraim Sehayek, M.D.Assistant Staff Genomic Medicine Institute (NE50) |
Secondary Appointments: Section of Preventive Cardiology and Rehabilitation, Cleveland Clinic
Academic Appointments: Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Research Assistant and Postdoctoral positions available
Education and Training:
Narrative Biosketch:
Dr. Sehayek completed his MD at the University of Tel Aviv, Sackler School of Medicine. He specialized in internal medicine at the Sheba Medical Center, Ramat Gan, Israel and was formally trained in Endocrinology and Metabolism at the Hadassah Medical Center in Jerusalem. Dr Sehayek was trained in laboratory-based human lipoprotein metabolism under the tutelage of Shlomo Eisenberg at the Lipid Research Center in Jerusalem. In 1996 Dr Sehayek was awarded the Lipper Clinical Scholar fellowship and joined the Laboratory of Biochemical Genetics and Metabolism at the Rockefeller University, New York, where he worked with Jan Breslow on mouse and human genetics of lipid metabolism. He joined the Genomic Medicine Institute in June of 2008.
Recent Peer Reviewed Publications:
1) E. Sehayek, L. R. Hagey, Y-Y Fung, E. M. Duncan, H. J. Yu, G. Eggertsen, I. Björkhem, A. F. Hofmann, J. L. Breslow. Two loci on chromosome 9 control bile acid composition in a C57BL/6J X CASA/Rk intercross: Evidence that a strong candidate gene, Cyp8b1, is not the culprit. J Lipid Res 47: 2020-2027, 2006.
2) E. Sehayek, H. J. Yu, K. von Bergmann, D. Lutjohann, M. Stoffel, E. M. Duncan, L.N. Gracia, J. Salit, M. Blundell, J. M. Friedman, J. L. Breslow. Phytosterolemia on the Island of Kosrae: A founder effect for a novel ABCG8 mutation results in a high carrier rate and increased plasma plant sterol levels. J Lipid Res 45: 1608-1613, 2004.
3) E. Sehayek, S.L. Hazen. Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages. Arterioscler Thromb Vasc Biol 28: 1296-1297, 2008.
4) E. M. Greenberg, J. D. Smith, and E. Sehayek. Moderately Decreased Cholesterol Absorption Rates Are Associated With a Large Atheroprotective Effect
Arterioscler Thromb Vasc Biol. 2009;29. In-Press.
5) E. E. Kenny, A. Gusev, K. Riegel, D. Lütjohann, J. K. Lowe, J. Salit, J. B. Maller, M. Stoffel, M. J. Daly, D. M. Altshuler, J. M. Friedman, J. L. Breslow, I. Pe'er, E. Sehayek. Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae. Proc Natl Acad Sci USA 106(33): 13886-13891, 2009.
Read more in the article which recently appeared in News and Notations from The Lerner Research Institute.
(go to publications page)