Area of Interest:
Cardiac and renal allograft rejection, vascular inflammation, innate immune responses.
Area of Interest:
Skin disease, Skin and cardiac allograft rejection, T cell recruitment to inflammation in peripheral tissues
Area of Interest:
Tumor immunity, T lymphocytes, signal transduction and transcription factors
Area of Interest:
Spatial organization and dynamics of B cell activation during an immune response
Area of Interest:
Autoimmunity; Systemic lupus erythematosus; Gender differences; The role of interferons in autoimmunity
Area of Interest:
Analysis of mechanisms regulating inflammatory gene expression in mononuclear phagocytes. Analysis of stimulus-dependent control of chemokine and cytokine mRNA stability.
Area of Interest:
Liver dendritic cells regulate hepatic immunity; Immunosuppressive activity of hepatic stellate cells
Area of Interest:
T cell homeostasis, Memory T cells, Role of basophils in adaptive immunity.
Area of Interest:
Our laboratory studies strategies to optimize the immune response to tumors for therapeutic purposes. We have found that we can sensitize T cells to weak tumor antigens in vaccine-draining lymph nodes and then purify recently stimulated T cells. These T cells can be activated in vitro to proliferate and acquire effector function and treat established tumor following adoptive transfer. We are currently working with a transgenic mouse model of HER2/neu breast cancer to define tumor-rejection antigens on cancer stem cells.
Area of Interest:
Transplantation Tolerance; Transplant Rejection; Liver Immunity; Dendritic Cell Biology; Co-stimulation; Transplant Microsurgery
Area of Interest:
Autoimmunity, Immunoregulation, T Cells, Gene Therapy
Area of Interest:
Transplant Immunology;Memory T Cells; T Cell Costimulation
