Recent Publications:

Peters K., S. Chattopadhyay and G.C. Sen. 2008. IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence. J. Virol. 82: 3500-8.

Borden E.C., G.C. Sen, G. Uze, R.H. Silverman, R.M. Ransohoff, G.R. Foster and G.R. Stark. 2007. Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6: 975-90.

Terenzi F., C. White, S. Pal, B.R. Williams and G.C. Sen. 2007. Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice. J. Virol. 81: 8656-65.

Sarkar S.N., C.P. Elco, K.L. Peters, S. Chattopadhyay and G.C. Sen. 2007. Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. J. Biol. Chem. 282: 3423-7.

Sen G.C. and G.A. Peters. 2007. Viral stress-inducible genes. Adv. Virus Res. 70: 233-63.

Kessler S.P., P. Senanayake, C. Gaughan and G.C. Sen. 2007. Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. FASEB J. 2007 21: 156-66.

Li, S., G.A. Peters, K. Ding, X. Zhang, J. Qin and G.C. Sen. 2006. Molecular basis for PKR activation by PACT or dsRNA. Proc. Natl. Acad. Sci. USA. 103: 10005-10010.

Biron, C.A. and G.C. Sen. 2006. Innate responses to viral infections. In “Fields Virology” Fifth Edition. (D.M. Knipe and P.M. Howley, Eds.) Lippincott, Williams and Wilkins, Philadelphia, PA, pp. 249-278.

Rowe, T.M., M. Rizzi, K. Hirose, G.A. Peters and G.C. Sen. 2006. A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing. Proc. Natl. Acad. Sci. USA. 103: 5823-5828.

Sen, G.C. and S.N. Sarkar. 2005. Transcriptional signaling by double-stranded RNA: role of TLR3. Cytokine and Growth Factor Rev. 16: 1-14.

Sarkar, S.N., K.L. Peters, C.P. Elco, S. Sakamoto, S. Pal and G.C. Sen. 2004. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in dsRNA-signaling. Nat. Struct. Mol. Biol. 11: 1060-1067.

Hartmann, R., J. Justesen, S.N. Sarkar, G.C. Sen and V.C. Yee. 2003. Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase. Mol. Cell. 12: 1173-1185.