Publications

  • Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J. Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J Invest Dermatol. 2009 Mar;129(3):553-63. PMID: 18800149
  • Rishavy MA, Berkner KL. Insight into the coupling mechanism of the vitamin K-dependent carboxylase: Mutation of His160 disrupts Glu carbanion formation and the efficient coupling of vitamin K epoxidation to Glu carboxylation. Biochemistry. 2008 Sep 16;47(37):9836-46. PMID: 18717596
  • Berkner KL. Vitamin K-dependent carboxylation. Vitam Horm. 2008 78:131–56. Review. PMID: 18374193
  • Rishavy MA, Hallgren KW, Yakubenko AV, Shtofman RL, Runge KW, Berkner KL. Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation. Biochemistry. 2006 Nov 7;45(44):13239–48. PMID: 17073445
  • Darghouth D, Hallgren KW, Shtofman RL, Mrad A, Gharbi Y, Maherzi A, Kastally R, LeRicousse S, Berkner KL, Rosa JP. Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes heredity combined vitamin K-dependent coagulation factor deficiency. Blood. 2006 Sept 15;108(6):1925–31. Epub 2006 May 23. PMID: 16720838
  • Hallgren KW, Qian W, Yakubenko AV, Runge KW, Berkner KL. r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step. Biochemistry. 2006 May 2;45(17):5587–98. PMID: 16634640
  • Rishavy MA, Hallgren KW, Yakubenko AV, Zuerner RL, Runge KW, Berkner KL. The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation. J Biol Chem. 2005 October 14;280(41):34870–7. Epub 2005 Aug 1. PMID: 16061481
  • Berkner KL. The vitamin K-dependent carboxylase. Annu Rev Nutr. 2005 25:127–49. Review. PMID: 16011462
  • Berkner KL, Runge KW. The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost. 2004 Dec;2(12):2118–32. Review. PMID: 15613016
  • Rishavy MA, Pudota BN, Hallgren KW, Qian W, Yakubenko AV, Song JH, Runge KW, Berkner KL. A new model for vitamin K-dependent carboxylation: The catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine. Proc Natl Acad Sci USA. 2004 Sept 21;101(38):13732–7. Epub 2004 Sept 13. PMID: 15365175
  • Hallgren KW, Hommema EL, McNally BA, Berkner KL. Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: Implications for the release of vitamin K-dependent proteins. Biochemistry. 2002 Dec 17;41(50):15045–55. PMID: 12475254
  • Pudota BN, Hommema EL, Hallgren KW, McNally BA, Lee S, Berkner KL. Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity. J Biol Chem. 2001 Dec 14;276(50):46878–86. Epub 2001 Oct 8. PMID: 11591726
  • Stenina O, Pudota BN, McNally BA, Hommema EL, Berkner KL. Tethered processivity of the vitamin K-dependent carboxylase: Factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo. Biochemistry. 2001 Aug 28;40(34):10301–9. PMID: 11513608
  • Pudota BN, Miyagi M, Hallgren KW, West KA, Crabb JW, Misono KS, Berkner KL. Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation. Proc Natl Acad Sci USA. 2000 Nov 21;97(24):13033–8. PMID: 11087858
  • Berkner KL. The vitamin K-dependent carboxylase. J Nutr. 2000 Aug;130(8):1877–80. Review. PMID: 10917896