Recent Publications:

Liu C, Qian W, Qian Y, Gitiay NV, Lu Y, Swaidani S, Misra S, Deng L, Chen ZJ, Li X. (2009) Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal. 2(92):ra63. PMID 19825828

Yang J, Ma YQ, Page RC, Misra S, Plow EF, Qin J. (2009) Structure of an integrin alpahllb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc Natl Acad Sci USA. 106(42):17729-34. PMID: 19805198

Xu Z, Page RC, Gomes MM, Kohli E, Nix JC, Herr AB, Patterson C, Misra S. (2008) Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag 2. Nat Struct Mol Biol. 15(12):1309-17. PMID: 19029896

Tejero J, Biswas A, WAng ZQ, Page RC, Haque MM, Hermann C, Zweier JL, Misra S, Stuehr DJ. (2008) Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem. 283(48):33498-507. PMID: 18815130

Das B, Gupta S, Vasanji A, Xu Z, Misra S, Sen S. (2008) Nuclear co-translocation of myotrophin and p65 stimulats myocyte growth. Regulation by myotrophin hairpin loops. J Biol Chem. 283(41):27947-56. PMID: 18693253

Xu Z, Kohli E, Devlin KI, Bold M, Nix JC, Misra S. (2008) Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. BMC Struct Biol. 8:26. PMID: 18485199

Z. Xu, K.I. Devlin, M.G. Ford, J.C. Nix, J. Qin and S. Misra. (2006) Structure and Interactions of the Helical and U-Box Domains of CHIP, the C Terminus of HSP70 Interacting Protein. Biochemistry. 45, 4749-4759.

X. Kong, X. Wang, S. Misra and J. Qin. (2006) Structural basis for the phosphorylation-regulated focal adhesion targeting of type Iγ phosphatidylinositol phosphate kinase (PIPKIg) by talin. J. Mol. Biol. In Press.

G. Prag, S. Misra , E.A. Jones, R. Ghirlando, B.A. Davies, B.F. Horazdovsky and J.H. Hurley. (2003) Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell . 113, 609-620. .Highlighted in Preview: (2003) Cell 113, 554-556.

S. Suer, S. Misra , L. F. Saidi and J.H. Hurley. (2003) Structure of the GAT domain of human GGA1: A syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Proc. Natl. Acad. Sci. 100, 4451-4456.

Y. Kato*, S. Misra* , R. Puertollano, J.H. Hurley and J.S. Bonifacino. (2002) Phosphoregulation of receptor sorting signal / VHS domain interactions by a direct electrostatic mechanism. Nature Struct. Biol. 9, 532-536. * co-first authors

S. Misra , R. Puertollano, Y. Kato, J.S. Bonifacino and J.H. Hurley (2002) Structural basis for acidic cluster-dileucine sorting signal recognition by VHS domains. Nature 415, 933-937. .Highlighted in News & Views: (2002) Nature Struct. Biol. 9, 241-244.

S. Misra , G.J. Miller and J.H. Hurley. (2001) Recognizing phosphatidylinositol 3-phosphate. Cell 107, 559-562.

J.H. Hurley and S. Misra (2000) Signaling and subcellular targeting by membrane binding domains. Annu. Rev. Biophys. Biomol. Struct. 29: 49-79.

S. Misra , B.M. Beach and J.H. Hurley (2000) Structure of the VHS domain of human tom1 (Target of myb 1): insights into interactions with proteins and membranes. Biochemistry 39: 11282-11290.

S. Misra and J.H. Hurley (1999) Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell 97, 657-666.

V.D. Rao, S. Misra , I.V. Boronenkov, R.A. Anderson and J.H. Hurley (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94, 829-839. .Highlighted in News & Views (1998) Nature Struct. Biol. 5, 843-846.