Sathyamangla V. Naga Prasad, Ph.D. Assistant Staff Department of Molecular Cardiology Lerner Research Institute / NB50 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 444- 3734 Fax: (216) 445-8204 prasads2@ccf.org

Area of General Research Interest:

• Regulation of G-protein coupled receptor (GPCR) signaling and resensitization in pathophysiology of heart failure.
• Role of cortical cytoskeleton in GPCR signaling.

Investigators:

• Gupta, Manveen, Ph.D., Postdoctoral Fellow
• Martelli, Elizabeth, Research Technician
• Mohan, Maradumane, Ph.D., Postdoctoral Fellow
• Vasudevan, Neelakantan Thiyyadi, Ph.D., Research Associate

Current Program:

• βAR resensitization by phosphoinositide 3-kinase (P13K) in heart failure
• Inrtracellular trafficking of GPCRs in hypertrophy and heart failure
• Regulation of βAR function by cortical cytoskeleton

Collaborators:

• Howard A. Rockman, M.D., Duke University Medical Center
• Randall Starling, M.D., Cardiovascular Medicine, Cleveland Clinic
• Christine S. Moravec, Ph.D., Cardiovascular Medicine, Cleveland Clinic
• W.H. Wilson Tag, M.D., Cardiovascular Medicine, Cleveland Clinic
• Joachim Neumann, M.D., University of Munster, Germany