Publications:

He, H., Liyanarachchi, S., Akagi, K., Nagy, R., Li, J., Dietrich, R.C., Li, W., Sebastian, N., Wen, B., Xin, B., Singh, J., Yan, P., Alder, H., Haan, E., Wieczorek, D., Albrecht, B., Puffenberger, E., Wang, H., Westman, J.A., Padgett, R.A., Symer, D.S. and de la Chapelle, A. (2011) Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I. Science. 332, 238-240.

Spies, N., Nielsen, C.B., Padgett, R.A. and Burge, C.B. (2009) Biased chromatin signatures around polyadenylation sites and exons. Mol Cell. 36, 245-254. PMCID: PMC2786773.

Singh, J. and Padgett, R.A. (2009) Rates of in situ transcription and splicing in large human genes. Nat Struct Mol Biol. 16, 1128-1133. PMCID: PMC2783620.

Dietrich, R.D., Padgett, R.A. and Shukla, G.C. (2009) The conserved 3’ end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome. RNA. 15, 1198-1207. PMCID: PMC2685526.

Brock, J.E., Dietrich, R.D. and Padgett, R.A. (2008) Mutational analysis of the U12-dependent branch site consensus sequence. RNA. 14, 2430-2439. PMCID: PMC2578861.

Dayie, K.T. and Padgett, R.A. (2008) A glimpse into the active site of a group II intron and maybe the spliceosome too. RNA. 14, 1697-1703. PMCID: PMC2525965.

Steitz, J.A., Dreyfuss, G., Krainer, A.R., Lamond, A.I., Matera, A.G. and Padgett, R.A. (2008) Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A. 105, 8485-8486. PMCID: PMC2438384.

Gumbs, O.H., Padgett, R.A. and Dayie, K.T. (2006) Fluorescence and solution NMR study of the active site of a 160 kDa group II intron ribozyme. RNA. 12,1693-1707. PMCID: PMC1557703.

Seetharaman, M., Eldho, N.V., Padgett, R.A. and Dayie, K.T. (2006) Structure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNA . RNA. 12, 235-247. PMCID: PMC1370903.

Dietrich, R.C., Fuller, J.D. and Padgett, R.A. (2005) A mutational analysis of U12-dependent splice site dinucleotides. RNA. 11,1430-1440.

Shukla, G.C. and Padgett, R.A. (2004) U4 small nuclear RNA can function in both the major and minor spliceosomes . Proc Natl Acad Sci U S A. 101, 93-98.

Shukla, G.C., Cole, A.J., Dietrich, R.D. and Padgett, R.A. (2002) Domains of human U4atac snRNA required for U12-dependent splicing in vivo. Nucl Acids Res. 30, 4650-4657.

Shukla, G.C. and Padgett, R.A. (2002) A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome. Mol Cell. 9, 1145-1150.

Dietrich, R.C., Shukla, G.C., Fuller, J.D. and Padgett, R.A. (2001) Alternative splicing of U12-dependent introns in vivo responds to purine-rich enhancers. RNA. 7, 1378-1388.

Dietrich, R.C., Peris, M.J., Seyboldt, A.S. and Padgett, R.A. (2001) Role of the 3' splice site in U12-dependent splicing. Mol Cell Biol. 21,1942-1952.

Shukla, G.C. and Padgett, R.A. (2001) The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop. RNA. 7, 94-105.

Shukla, G.C. and Padgett, R.A. (1999) Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants. RNA. 5, 525-538.

Burge, C.B., Padgett, R.A. and Sharp, P.A. (1998) Evolutionary fates and origins of U12-type introns. Mol Cell. 2, 773-785.

Podar, M., Perlman, P.S. and Padgett, R.A. (1998) The two steps of group II self-splicing are mechanistically distinguishable. RNA. 4, 890-900.

Incorvaia, R. and Padgett, R.A. (1998)  Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo. RNA. 4, 709-718.

Dietrich, R.C., Incorvaia, R. and Padgett, R.A. (1997)  Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns. Mol Cell. 1, 151-160.

Hall, S.L. and Padgett, R.A. (1996) Requirement of U12 snRNA for in vivo splicing of a minor class of eukaryotic nuclear introns. Science. 271,1716-1718.