Selected Publications

Guenthoer, J., Diede, S.J., Tanaka, H., Chai, X., Hsu, L., Tapscott, S.J. and Porter, P.L. (2011) Assessment of palindromes as platforms for DNA amplification in breast cancer.
Genome Res. Jul 13. [Epub ahead of print]

Diede, S.J., Tanaka, H., Bergstrom, D.A., Yao, M.C. and Tapscott, S.J. (2010) Genome-wide analysis of palindrome formation. Nat Genet. 42, 279. PMCID: PMC2935268.

Diede, S.J., Guenthoer, J., Geng, L.N., Mahoney, S.E., Marotta, M., Olson, J.M., Tanaka, H., Tapscott, S.J. (2010) DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences. Proc Natl Acad Sci U S A. 107, 234-239. PMCID: PMC2806770.

Lin, C.H., Lin, C., Tanaka, H., Fero, M.L. and Eisenman, R.N. (2009) Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 4, e7839. PMCID: PMC2773118.

Zhao, Y., Marotta, M., Eichler, E.E., Eng, C. and Tanaka, H. (2009) Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes. PLoS Genet. 5, e1000472. PMCID: PMC2672168.

Tanaka, H. and Yao, M.C. (2009) Palindromic gene amplification--an evolutionarily conserved role for DNA inverted repeats in the genome. Nat Rev Cancer. 9, 216-224.

Tanaka , H., Cao, Y, Bergstrom, D.A., Kooperberg, C., Tapscott S. J. and Yao, M. C. (2007) Intra-strand annealing leads to the formation of large DNA palindrome and determine the boundaries of genomic amplification in human cancer. Mol Cell Biol. 27, 1993-2002. PMCID: PMC1820508.

Tanaka, H., Bergstrom, D.A., Yao, M.C. and Tapscott, S.J. (2006) Large DNA palindromes as a common form of structural chromosome aberrations in human cancers. Hum Cell. 19, 17-23.

Tanaka, H., Bergstrom, D. A., Yao , M. C. and Tapscott, S. J. (2005). Widespread and non-random distribution of DNA palindromes provides a structural platform for subsequent gene amplification. Nat Genet. 37, 320-327.

Tanaka. H., Tapscott, S.J., Trask, B.J. and Yao , M.C. (2002). Short Inverted repeats initiate gene amplification through the formation of large DNA palindrome in mammalian cells. Proc Natl Acad Sci U S A. 99, 8772-8777.

Harada, H., Tanaka, H., Shimada, Y., Shinoda, M., Imamura, M. and Ishizaki, K. (1999). Lymph node metastasis is associated with allelic loss on chromosome 13q12-13 in esophageal squamous cell carcinoma. Cancer Res. 59, 3724-3729.

Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M. and Ishizaki, K. (1998). Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res. 58, 3429-3434.

Tanaka, H., Shimada, Y., Imamura, M., Shibagaki, I. and Ishizaki, K. (1997). Multiple types of aberrations in the p16 (INK4a) and p15 (INK4b) genes in 30 esophageal squamous cell carcinoma cell lines. Int J Cancer. 70, 437-442.

Tanaka, H., Shibagaki, I. , Shimada, Y., Wagata, T., Imamura, M. and Ishizaki, K., (1996). Characterization of the p53 gene mutations in esophageal squamous cell carcinoma cell lines: Increased frequency and different spectrum of mutations from primary tumors. Int J Cancer. 65, 372-376.