Yu-Shang Lee, Ph.D.
Assistant Professor, Medicine, CCLCM-CWRU
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-5040
Fax: (216) 444-7927
Our laboratory studies the potential treatment of spinal cord injury using nerve regeneration strategies and neurorehabilitation approaches to restore functional recovery. Pathological changes at spinal cord injury site creates non-permissive environment for axonal regeneration. The key leads to regain functional recovery are to encourage more axons to cross the damaged site and have proper connection with target neurons. A major focus is using peripheral nerve transplantation with growth factors, chondroitinase ABC, and also combining other cellular transplantation or rehabilitation methods to promote systematic recovery such as motor, sensory, skeletal muscles, and autonomic function after spinal cord injury. Another project area is focused on the problems of post-traumatic stress disorder, hearing, and autonomic disorders after traumatic brain injury and the potential solutions for these problems.
In other words ...
Spinal cord injury (SCI) is one of the most damaging, immobilizing, and irreversible injuries that a patient can survive. There are over 1,275,000 SCI patients living in the United States, yet no cure exists to date. My research focus is on the potential treatment of SCI which results in a change, either temporary or permanent, in its normal motor, sensory, or autonomic function. We use nerve bridging technique to repair the injured site and neurorehabilitation approaches and to restore lost function.
Selected Publications (2014-present):
Sun K, Li X, Chen X, Bai Y, Zhou G, Kokiko-Cochran ON, Lamb B, Hamilton TA, Lin CY, Lee YS, Herjan T. (2018) Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease. J Immunol. 201(1):157-166. PMID: 29760195; PMCID: PMC6008238
Lin CY, Androjna C, Rozic R, Nguyen B, Parsons B, Midura RJ, Lee YS. (2018) Differential Adaptations of the Musculoskeletal System after Spinal Cord Contusion and Transection in Rats. J Neurotrauma 35(15):1737-1744. PMID: 29402167
Kokiko-Cochran ON, Saber M, Puntambekar S, Bemiller SM, Katsumoto A, Lee YS, Bhaskar K, Ransohoff RM, Lamb BT. (2018) Traumatic Brain Injury in hTau Model Mice: Enhanced Acute Macrophage Response and Altered Long-Term Recovery. J Neurotrauma 35(1):73-84. PMID: 28859549; PMCID: PMC5757085
DePaul MA, Lin CY, Silver J, Lee YS. (2017) Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury. Sci Rep. 7(1):9018. PMID: 28827771; PMCID: PMC5567101
Park KW, Lin CY, Benveniste EN, Lee YS. (2016) Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury. Exp Neurol. 284(Pt A):98-105. PMID: 27502766; PMCID: PMC5035219
DePaul MA, Lin CY, Silver J, Lee YS. (2015) Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice. PLoS One 10(10):e0139335. PMID: 26426529; PMCID: PMC4591338
Kokiko-Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, Teknipp R, Xu G, Bemiller S, Wilson G, Crish S, Bhaskar K, Lee YS, Ransohoff RM, Lamb BT. (2015) Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma 33(7):625-40. PMID: 26414955; PMCID: PMC4971425
Park KW, Lin CY, Li K, Lee YS. (2015) Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury. PLoS One 10(9):e0138301. PMID: 26384335; PMCID: PMC4575181
Lin CY, Huang WJ, Li K, Swanson R, Cheung B, Lin VW, Lee YS. (2015) Differential intensity-dependent effects of magnetic stimulation on the longest neurites and shorter dendrites in neuroscreen-1 cells. J Neural Eng. 12(2):026013. PMID: 25769013; PMCID: PMC4400261
Park KW, Lin CY, Lee YS. (2014) Expression of suppressor of cytokine signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury. Exp Neurol. 261:65-75. PMID: 24959867; PMCID: PMC4194224
Lin CY, Li K, Franic L, Gonzalez-Martinez J, Lin VW, Najm I, Lee YS. (2014) Frequency-dependent effects of contralateral repetitive transcranial magnetic stimulation on penicillin-induced seizures. Brain Res. 1581:103-16. PMID: 24937795
Kurt Spindler, MD, co-director of Cleveland Clinic’s Musculoskeletal Research Center, was awarded a five-year, $6 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study techniques used for anterior cruciate ligament (ACL) reconstruction.