Wendy B. Macklin, Ph.D. Staff Department of Neurosciences Lerner Research Institute / NC30 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 445-2680 Fax: (216) 444-7927 mackliw@ccf.org

Area of general research interest:

Molecular control of oligodendrocyte differentiation during brain development.

Current program:

• Studies on the regulatory elements of the myelin proteolipid protein gene.
• Studies on animals carrying mutations in the myelin proteolipid protein gene.
• Studies using a PLP-Lac2 transgene to track oligodendrocyte differentiation on normal and mutant animals.
• Studies on a GTPase activity protein in oligodendrocytes and neurons.

Investigators:

• Ana Flores, Ph.D.
• Yuko Fujita, Ph.D.
• Tatyana Gudz, Ph.D.
• Cindy Kangas
• Elizabeth Schick, B.S.

Collaborators:

• Dr. Robert Miller, Dept. of Neurosciences, Case Western Reserve University, Cleveland, OH
• Dr. Phillip Kahle, Dept. of Biochemistry, Ludwig Maximilians University, Munich, Germany
• Dr. Steve Stohlman, Dept. of Neurology, Keck SOM, University of Southern California, Los Angeles, CA