Wendy B. Macklin, Ph.D. | Research | Publications | Laboratory

Publications

  1. Macklin WB, Campagnoni CW, Deininger PL and Gardinier MV. Structure and expression of the mouse myelin proteolipid protein gene. J Neurosci Res 1987; 18:395-401.
  2. Campagnoni AT and Macklin WB. Cellular and molecular aspects of myelin protein gene expression. Molec. Neurobiol. 1988; 2:41-89. LeVine SM and Macklin WB. Biotin enrichment in oligodendrocytes in the rat brain. Brain Res. 1988; 444:199-203.
  3. Gardinier MV and Macklin WB. Myelin proteolipid protein gene expression in jimpy and jimpymsd mice. J Neurochem 1988; 51:360-369.
  4. Macklin WB, and Weill CL. Appearance of myelin proteins during development in the chick central nervous system. Develop Neurosci 1989; 7:170-178.
  5. Macklin WB and Campagnoni CW. Isolation and structure determination of genes. In: Campagnoni AT, editor. Neuromethods: Molecular Neurobiology. New Jersey:Humana Press,1989; 16:117-151.
  6. Gardinier MV and Macklin WB. Developmental expression of the myelin proteolipid protein gene. In: Jeserich G, editor. Cellular and Molecular Biology of Myelination. Berlin:Springer-Verlag, 1989; 517-532.
  7. Kumar S, Macklin WB, Gordon MN, Espinosa de los Monteros A, Cole R, Scully SA and de Vellis J. Transcriptional regulation studies of myelin associated genes in md mutant rats. Develop Neurosci 1990; 12:316-325.
  8. LeVine SM, Wong D and Macklin WB. Developmental expression of the PLP and DM20 mRNAs and proteins in the rat brain. Develop Neurosci 1990; 12:235-250.
  9. Macklin WB, Gardinier MB and Obeso ZO. Structure and expression of the mouse myelin proteolipid protein gene. Ann N Y Acad Sci 1990; 605:183-193.
  10. Levine SM and Macklin WB. Iron-enriched oligodendrocytes: A reexamination of their spatial distribution. J Neurosci Res 1990; 26:508-512.
  11. Macklin WB, Gardinier MV, Obeso ZO, King KD and Wight PA. Mutations in the myelin proteolipid protein gene alter oligodendrocytes gene expression in jimpy and jimpymsd mice. J Neurochem 1991; 56:163-271.
  12. Asotra K and Macklin WB. Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes. J Neurosci Res 1993; 34:571-588.
  13. Shirazi Y, Rus HG, Macklin WB, and Shin ML. Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes. J Immunol 1993; 150-4581-4590.
  14. Wight PA, Duchala CS, Readhead C and Macklin WB. A myelin proteolipid-Lac Z fusion gene is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol 1993; 123:443-454.
  15. Asotra K and Macklin WB. A comparison of affinity purified and protein G-purified antibodies for the immunocytochemical detection of protein kinase C isozymes. Focus 1993; 15:94-98.
  16. Baba H, Fuss B, Watson JB, Zane LT and Macklin WB. Identification of novel mRNAs expression in oligodendrocytes. Neurochem Res 1994; 19:1091-1099.
  17. Asotra K, and Macklin WB. Differential expression of protein kinase C isozymes in cells of oligodendroglial lineage. J Neurosci Res 1994; 39:273-289.
  18. Duchala CS, Asotra K and Macklin WB. Different developmental patterns of mouse and rat oligodendrocytes in culture. Dev Neurosci 1995; 17:70-80.
  19. Baba H, Fuss B, Watson JB and Macklin WB. GAPIII, a new brain-enriched member of the GTPase-activating protein family. J Neurosci Res 1995; 41:846-858.
  20. Duchala CS, Fuss B and Macklin WB. Use of transgenic systems to investigate oligodendrocyte differentiation and function. Meth Enzymol 1996; 10:478-488.
  21. Trapp BD, Nishiyama A, Cheng D and Macklin WB. Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. J Cell Biol 1997; 137:459-468.
  22. Fuss B, Baba H, Phan T, Tuohy VK and Macklin WB. Phosphodiesterase I/nucleotide pyrophosphatase - a novel adhesion molecule and/or cytokine involved in oligodendrocyte function? J Neurosci 1997; 17:9095-9103.
  23. Wight PA, Dobretsova A and Macklin WB. Regulation of murine proteolipid protein gene expression. J Neurosci Res 1997; 50:917-922.
  24. Neri CL, Duchala CS and Macklin WB. Expression of molecular chaperones and protein processing proteins in differentiating oligodendrocytes. J Neurosci Res 1997; 50:769-780.
  25. Spassky N, Goujet?Zalc C, Parmantier E, Olivier C, Martinez S, Ivanova A, Ikenaka K, Macklin W, Cerruti I, Zalc B, and Thomas J?L. Multiple restricted origin of oligodendrocytes. J Neuroscience 1998; 18:8331?8343.
  26. Kawczak JA, Mathisen PM, Drazba JA, Fuss B, Macklin WB, and Tuohy VK. Digitized image analysis reveals diffuse abnormalities in normal appearing white matter during acute experimental autoimmune encephalomyelinitis. J Neurosci Res 1998; 54: 364?372.
  27. das Neves L, Duchala CS, Godinho F, Haxhiu MA, Colmenares C, Macklin WB, Campbell C, Butz KG, and Gronostajski R. Disruption of the murine Nuclear Factor I-A (Nfia) results in perinatal lethality, hydrocephalus and agenesis of the corpus callosum. Proc Natl Acad Sci. 1999; 96:11946?51.
  28. Garbern JY, Cambi F, Lewis R, Shy M, Sima A, Kraft G, Vallat JM, Bosch EP, Hodes ME, Dlouhy S, Raskind W, Bird T, Macklin W, and Kamholz J. Peripheral neuropathy caused by proteolipid protein gene mutations. Ann NY Acad Sci. 1999; 883:351-365.
  29. Fuss B, Mallon B, Phan T, Ohlemeyer C, Kirchhoff F, Nishiyama A, and Macklin WB. Purification and analysis of in vivo differentiated oligodendrocytes expressing the green fluorescent protein. Developmental Biology 2000; 218:259-274.
  30. Jiang H, Duchala CS, Awatramani R, Shumas S, Carlock L, Kamholz J, Garbern J, Scherer SS, Shy ME, and Macklin WB. Proteolipid protein mRNA stability is regulated by axonal contact in the rodent peripheral nervous system. J Neurobiology 2000; 44:7-19.
  31. Flores AI, Mallon B, Nishiyama K, Matsui T, Ogawa W, Kasuga M, Kikkawa U, Rosensweig A, Okamoto T, and Macklin WB. AKT-mediated survival of oligodendrocytes induced by neuroregulins. J Neuroscience in press, 2000.
  32. Fuss B, Afshari S, Colello RJ and Macklin WB. Normal CNS myelination in transgenic mice overexpressing MHC I H-2Ld in oligodendrocytes, Molecular and Cellular Neuroscience 18:221-234, 2001.
  33. Mallon BS, Shick HE, Kidd GJ and Macklin WB. Proteolipid promoter activity distinguishes two populations of NG2-positive cells throughout neonatal cortical development. J. Neuroscience, in press 2001.
  34. Papay, R., Zuscik, M..J. Ross, S.A., Yun, J., McCune D..F., Gonzalez-Cabrera, P., Gaivin, R., Macklin, W.B. and Perez, D.M. Mice expressing of the a1b-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation, J. Neurochem, 83:623-634, 2002.
  35. Doerflinger, N.H., Macklin, W.B. and Popko, B. Inducible site-specific recombination in myelinating cells, Genesis 35:63-72, 2003. Miller, M.J., Haxhiu,M.A., Georgiadis, P., Gudz, T.I., Kangas, C., and Macklin W.B. Proteolipid protein gene mutation induces altered ventilatory response to hypoxia in the myelin deficient rat, J. Neuroscience 23:2265-2273, 2003.
  36. Leone DP, Genoud S, Atanasoski S, Grausenburger R, Berger P, Metzger D, Macklin WB, Chambon P, Suter U. Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 22:430-40, 2003.
  37. Fox MA, Colello RJ, Macklin WB, Fuss B. PD-la/ATZ (NPP-2): A counter adhesiver protein expressed by oligodendrocytes during onset of myelination. Mol Cell Neurosci 23:507-519, 2003.
  38. Duchala CS, Shick HE, Garcia J, DeWeese DM, Sun X, Stewart VJ, Macklin WB. The toppler mouse: a novel mutant exhibiting loss of Purkinje cells. J Comp Neurol. 476:113-119, 2004.
  39. Miller MJ, et al. Selective alteration of the ventilatory response to hypoxia results from mutation in the myelin proteolipid protein gene. Adv Exp Med Biol  2004;551:85-91.
  40. Papay R, Gaivin R, McCune DF, Rorabaugh BR, Macklin WB, McGraith JC, Perez DM. Mouse alpha1b-adrenergic receptor is expressed in neurons and NG2 oligodendrocytes. J Comp Neurol. 478:1-10, 2004.
  41. Gudz TI, Komuro H, Macklin WB.  Glutamate stimulates oligodendrocyte progenitor migration mediated via an av integrin/myelin proteolipid protein complex. J Neurosci  2006;26:2458-66.
  42. Wight PA, et al. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res  2007;32:343-51.

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