Riqiang Yan, Ph.D. | Research | Publications | Laboratory

Publications

  1. Yan,R., Luo,H., Darnell,J.E., Jr., and Dearolf,C.R. (1996a). A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. U. S. A 93, 5842-5847.
  2. Yan,R., Small,S., Desplan,C., Dearolf,C.R., and Darnell,J.E., Jr. (1996b). Identification of a Stat gene that functions in Drosophila development. Cell 84, 421-430.
  3. Zong,C., Yan,R., August,A., Darnell,J.E., Jr., and Hanafusa,H. (1996). Unique signal transduction of Eyk: constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase. EMBO J. 15, 4515-4525.
  4. Yan,R., Bienkowski,M.J., Shuck,M.E., Miao,H., Tory,M.C., Pauley,A.M., Brashier,J.R., Stratman,N.C., Mathews,W.R., Buhl,A.E., Carter,D.B., Tomasselli,A.G., Parodi,L.A., Heinrikson,R.L., and Gurney,M.E. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537.
  5. Yan,R., Han,P., Miao,H., Greengard,P., and Xu,H. (2001a). The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J. Biol. Chem. 276, 36788-36796.
  6. Yan,R., Munzner,J.B., Shuck,M.E., and Bienkowski,M.J. (2001b). BACE2 functions as an alternative alpha-secretase in cells. J. Biol. Chem. 276, 34019-34027.
  7. Li,J., Pauley,A.M., Myers,R.L., Shuang,R., Brashler,J.R., Yan,R., Buhl,A.E., Ruble,C., and Gurney,M.E. (2002). SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. J. Neurochem. 82, 1540-1548.
  8. Yang,L.B., Lindholm,K., Yan,R., Citron,M., Xia,W., Yang,X.L., Beach,T., Sue,L., Wong,P., Price,D., Li,R., and Shen,Y. (2003). Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4.
  9. Tomasselli,A.G., Qahwash,I., Emmons,T.L., Lu,Y., Leone,J.W., Lull,J.M., Fok,K.F., Bannow,C.A., Smith,C.W., Bienkowski,M.J., Heinrikson,R.L., and Yan,R. (2003). Employing a superior BACE1 cleavage sequence to probe cellular APP processing. J. Neurochem. 84, 1006-1017.
  10. Qahwash,I., Weiland,K.L., Lu,Y., Sarver,R.W., Kletzien,R.F., and Yan,R. (2003). Identification of a mutant amyloid peptide that predominantly forms neurotoxic protofibrillar aggregates. J. Biol. Chem. 278, 23187-23195.
  11. He,W., Lu,Y., Qahwash,I., Hu,X.Y., Chang,A., and Yan,R. (2004). Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat. Med. 10, 959-965.
  12. Li,R., Lindholm,K., Yang,L.B., Yue,X., Citron,M., Yan,R., Beach,T., Sue,L., Sabbagh,M., Cai,H., Wong,P., Price,D., and Shen,Y. (2004). Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc. Natl. Acad. Sci. U. S. A 101, 3632-3637.
  13. Qahwash,I., He,W., Tomasselli,A., Kletzien,R.F., and Yan,R. (2004). Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. J. Biol. Chem. 279, 39010-39016.
  14. He,W., Hu,X., Shi,Q., Zhou,X., Lu,Y., Fisher,C., and Yan,R. (2006). Mapping of Interaction Domains Mediating Binding between BACE1 and RTN/Nogo Proteins. J. Mol. Biol. 363, 625-634.
  15. Hu,X., Hicks,C.W., He,W., Wong,P., Macklin,W.B., Trapp,B.D., and Yan,R. (2006). Bace1 modulates myelination in the central and peripheral nervous system. Nat. Neurosci. 9, 1520-1525.
  16. Wojcik,S., Engel,W.K., Yan,R., McFerrin,J., and Askanas,V. (2007). NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in AbetaPP-overexpressing cultured human muscle fibers. Acta Neuropathol. (Berl) 114, 517-526.
  17. He,W., Shi,Q., Hu,X., and Yan,R. (2007). The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1. J. Biol. Chem. 282, 29144-29151.
  18. Hu,X., Shi,Q., Zhou,X., He,W., Yi,H., Yin,X., Gearing,M., Levey,A., and Yan,R. (2007). Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO J. 26, 2755-2767.
  19. Hu,X., He,W., Diaconu,C., Tang,X., Kidd,G.J., Macklin,W.B., Trapp,B.D., and Yan,R. (2008). Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J. In press.
  20. Breij,E.C., Brink,B.P., Veerhuis,R., van den,B.C., Vloet,R., Yan,R., Dijkstra,C.D., van,d., V, and Bo,L. (2008). Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann. Neurol. 63, 16-25.
  21. Carter,D.B., Dunn,E., Pauley,A.M., McKinley,D.D., Fleck,T.J., Ellerbrook,B.R., Stratman,N.C., Zhou,X., Himes,C.S., Nye,J.S., Tomasselli,A., and Yan,R. (2008). Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1. Mol. Neurodegener. 3, 6.