The War on Cancer was declared 40 years ago, and it is still on…this calls for changing our approach to studying the disease. Read Full Article
The National Alzheimer's Project Act (NAPA) was signed into law, giving hope to those affected by this disease…see how this connects to a Lerner Research Institute researcher. Read Full Article
Lerner Research Institute programs to attract and train the best of the best research trainees. Read Full Article
Maternal obesity, breast cancer, and Alzheimer's are the focus of new grants at the Lerner Research Institute. Read Full Article
LRI expert in antiviral innate immunity in human health and disease has been elected to the American Academy of Microbiology, the honorific leadership group of the American Society for Microbiology. Read Full Article
LRI researchers honored for contributions to science and technology. Three investigators have been elected to the American Association for the Advancement of Science. Read Full Article
This year's award goes to a researcher working toward developing a prophylactic breast cancer vaccine. Read Full Article
Newest research reveals a biological pathway that transforms normal cells into aggressive tumors. Read Full Article
Historic evidence from Abraham Lincoln's death has been used by GMI researchers in a documentary filmed by National Geographic. Did Lincoln have cancer? Read Full Article
One of the ways scientists serve: A researcher's role is not limited to astute observations that derive medical applications... Read Full Article
HIV and autoimmune disease, pregnancy-induced hypertension, and the blood-brain barrier are areas funded by new grants. Read Full Article
Stanley Hazen, MD, PhD, and Zeneng Wang, PhD, Cell Biology, and colleagues at the Lerner Research Institute have discovered a new pathway that links a common dietary lipid and gut flora (microbes that reside in intestines) to the development of cardiovascular disease (CVD). Read Full Article
New research led by Shideng Bao, PhD, Associate Staff, and Jeremy Rich, MD, Chair, Stem Cell Biology and Regenerative Medicine, reveals a new therapeutic target for glioblastomas. Read Full Article
A testament to the profound effect subcellular processes can have on disease: A group at Ohio State University (OSU) studying a rare but lethal condition found locally in the Ohio Amish population sought out the scientific expertise of Ohio researcher Richard Padgett, PhD, Molecular Genetics, to discover the genetic basis of the disease. Read Full Article
Hand therapy device for stroke patients; Oncogenes and tumor resistance; Family health history; Implementing genomic medicine; Microflora and heart disease; Aerobic exercise and nonalcoholic fatty liver disease; Adverse effects of some hairstyles; Predicting prognosis in MS; Unlocking brain potential; New MS diagnostic guidelines. Read Full Article
The Lerner Research Institute's Department of Biomedical Engineering new chair brings a unique combination of research expertise and innovation to the Institute. Read Full Article
The Edward F. and Barbara A. Bell Family Endowed Chairholder has been named and the Alzheimer's Association National Civic Award draws Senate attention. Read Full Article
New directives for researching Duchenne muscular dystrophy, tobacco smoke and the blood-brain barrier, and carpal tunnel syndrome have been awarded by the National Institutes of Health Read Full Article
A rare genetic disease and its complications. Rocio Moran, MD, Medical Director of the clinical arm of the Genomic Medicine Institute, diagnoses a six-year old girl with a rare and debilitating genetic disease. Continuing to work with this remarkable young girl and her family, Dr. Moran wants to identify the underlying genetic cause of the disease, leading to better disease management and possibly a cure. Read Full Article
An undergraduate spokesman for increased research funding gets through to the President. Undergraduate researcher in Cell Biology meets President Obama face to face and uses historical examples to personally express the importance of and need for funding research. Read Full Article
Expertise in kidney development and polycystic kidney disease (PKD) joins Cell Biology with a clinically relevant research program from Louisiana State University Health Sciences Center. Currently, the only treatments available for end-stage renal failure by PKD are dialysis and kidney transplantation. Oliver Wessely, PhD, hopes that his research will make kidney regeneration a third possibility.
A leader in brain tumor treatment and research has joined Cancer Biology from Columbia University. Steven S. Rosenfeld, MD, PhD. has been recruited to set up, integrate and direct a brain tumor translational research program here. Read Full Article
Two new grants related to cancer bring over $11 million to the Institute. Read Full Article
Researchers at Cleveland Clinic have for the first time linked three genes to Barrett's esophagus and/or esophageal cancer. Identifying such genetic markers will allow risk assessment, early detection, improved disease management, and ultimately increased survival. Read Full Article
2011 marks more than one milestone for Cleveland Clinic. It is not only the 90th Anniversary of the hospital overall, but also the 20th Anniversary of an integral part of the Lerner Research Institute, the John Sherwin Research Building. This building opened as a result of philanthropic support from the Sherwick Fund, which provided the essential funds to jumpstart discovery and cures. Many discoveries have come from departments housed in this building, including advances in Alzheimer's, cardiovascular, and kidney diseases; cancer; multiple sclerosis; asthma; diabetes; and nonalcoholic fatty liver disease. Read Full Article
The Department of Neurosciences welcomes a new program specializing in how injury of the central nervous system's white matter relates to stroke and aging, headed by Selva Baltan, MD, PhD. Her studies also provide insights into other conditions, including traumatic brain injury, multiple sclerosis, spinal cord injury, age-related dementia, Alzheimer's disease, and age-related diseases of the eye. Personal inspiration drives her dedication to research and public awareness. Read Full Article
This innovative graduate program, designed to train students to translate scientific observations into clinical answers, celebrates the arrival of its 5th class. Meet the class! Read Full Article
Lerner Research Institute investigators have recently received some particularly highly coveted, peer-reviewed grant awards, underscoring the high caliber research talent in the Institute. See what research is being supported by over $26M in new awards. Read Full Article
Former Institute Chair, Dr. Bernadine P. Healy, died on Saturday, August 6, 2011. She is responsible for the vision of a united research facility on the Cleveland Clinic campus. Read Full Article
Cleveland Clinic researcher named to the Expert Panel of the World Health Organization project, "Grand Challenges in Genomics for Public Health in Developing Countries." Read Full Article
The Scientist polled its readership of full-time life scientists working in noncommercial, identifiable organizations to come up with a list of 92 institutions in the United States. Cleveland Clinic's #16 ranking is up from #33 just one year ago. Read Full Article
New findings suggest that existing medications may be useful against brain tumors, according to research from Stem Cell Biology and Regenerative Medicine Read Full Article
Emerging technology provides non-invasive testing for liver disease, heart disease, lung disease, cancer, asthma, and other maladies Read Full Article
Asthma, viruses, liver disease, lupus, and cardiovascular disease projects receive funding Read Full Article
Technology that emerged from a study on Parkinson's disease has been tweaked for another application – an iPAD app – to assist clinicians in concussion management. Read Full Article
Awardees from Pathobiology and Solid Tumor Oncology. Read Full Article
Lerner Research Institute connected to successful Cleveland Clinic spinoff company Cleveland Heart Lab, Inc (CHL). Read Full Article
Radiation oncologist from the University of California, San Francisco, joins the Stem Cell Biology and Regenerative Medicine research team to investigate brain tumors. Read Full Article
Funding for research on ophthalmology, concussions, and heart transplants. Read Full Article
Unprecedented interception of pain (Dr. Lin)
Relief from chronic pain is a major priority for the 1,000,000 US residents that suffer from spinal cord injury (SCI). Ching-Yi Lin, PhD, Neurosciences, led a new study showing that a single injection of a naturally occurring protein leads to an unprecedented inhibition of chronic SCI pain for over eight months in an experimental model.
New study defines markers that distinguish a subset of colon cancers (Dr. Ting)
Angela Ting, PhD, GMI, led genome-wide research to confirm that a subset of colon cancers called CIMP are characterized by a process called "DNA methylation" of specific genes. Researchers used strict guidelines to characterize CIMP colon tumors and suggest that their definition may rectify the usefulness of CIMP status as a prognostic indicator. Dr. Ting's study shows that the hypermethylation noted in CIMP tumors affects all 12 core cancer signaling pathways. Read Full Article
Cleveland Clinic researchers in the media: Deadly brain tumors receiving new treatments (Drs. Barnett and Vogelbaum); Attacking stealthy heart disease (Drs. Cho and Hazen); One gene, opposite roles in two cancers (Dr. Eng); On the cover (Dr. Eng); Alpha1a adrenergic receptor stimulation and longevity (Dr. Perez); New drug for kidney cancer (Dr. Rini). Read Full Article
New research center (Dr. Rosenfeld)
The Lerner Research Institute recognizes that the quickest way to the biggest impact on human health is through physician-scientist collaborations within disease-based Centers of Excellence in research. Under the leadership of Steven Rosenfeld, MD, PhD, Cancer Biology, the mission of this first Center of Excellence in cancer research is to "translate" scientific findings into diagnostic and therapeutic interventions to improve the lives of patients afflicted with brain tumors.
Seeding a program for seed money (Dr. Stark)
George Stark, PhD, Distinguished Institute Scientist, Emeritus Professor of Genetics, Case Western Reserve University, and former Lerner Research Institute Chair, is an internationally recognized leader in science. Now he leads donor efforts by launching the Laboratory Research Partnership Initiative with a personal gift. Read Full Article
Focus on the Department of Neurosciences! A grant awarded to John T. Gale, PhD, aims to provide high speed and natural movements to prosthetic limbs, while a closer look at multiple sclerosis has been made possible by a grant to Richard Ransohoff, MD. Read Full Article
Dr. Ransohoff and colleagues study tissue affected by early-stage multiple sclerosis and discover a pivotal role of the brain's grey matter – a role that opposes traditional understanding. Read Full Article
More coverage for the iPad concussion app (Dr. Alberts); Combating concussion (Dr. Bartsch); Why family health history is important (Dr. Eng); $10M gift to CC Innovations (Dr. Thomas Graham). Read Full Article
Award for Excellence in Basic Research (Dr. Lathia). Read Full Article
New grants fund research on the significance of a brain tumor's immediate surroundings … and support studies addressing how gene expression is controlled (and how deficiencies lead to disease). Read Full Article