Vol. 15, No. 9
Unprecedented interception of pain (Dr. Lin)
Relief from chronic pain is a major priority for the 1,000,000 US residents that suffer from spinal cord injury (SCI). Ching-Yi Lin, PhD, Neurosciences, led a new study showing that a single injection of a naturally occurring protein leads to an unprecedented inhibition of chronic SCI pain for over eight months in an experimental model.
New study defines markers that distinguish a subset of colon cancers (Dr. Ting)
Angela Ting, PhD, GMI, led genome-wide research to confirm that a subset of colon cancers called CIMP are characterized by a process called "DNA methylation" of specific genes. Researchers used strict guidelines to characterize CIMP colon tumors and suggest that their definition may rectify the usefulness of CIMP status as a prognostic indicator. Dr. Ting's study shows that the hypermethylation noted in CIMP tumors affects all 12 core cancer signaling pathways. Read Full Article
Cleveland Clinic researchers in the media: Deadly brain tumors receiving new treatments (Drs. Barnett and Vogelbaum); Attacking stealthy heart disease (Drs. Cho and Hazen); One gene, opposite roles in two cancers (Dr. Eng); On the cover (Dr. Eng); Alpha1a adrenergic receptor stimulation and longevity (Dr. Perez); New drug for kidney cancer (Dr. Rini). Read Full Article
New research center (Dr. Rosenfeld)
The Lerner Research Institute recognizes that the quickest way to the biggest impact on human health is through physician-scientist collaborations within disease-based Centers of Excellence in research. Under the leadership of Steven Rosenfeld, MD, PhD, Cancer Biology, the mission of this first Center of Excellence in cancer research is to "translate" scientific findings into diagnostic and therapeutic interventions to improve the lives of patients afflicted with brain tumors.
Seeding a program for seed money (Dr. Stark)
George Stark, PhD, Distinguished Institute Scientist, Emeritus Professor of Genetics, Case Western Reserve University, and former Lerner Research Institute Chair, is an internationally recognized leader in science. Now he leads donor efforts by launching the Laboratory Research Partnership Initiative with a personal gift. Read Full Article
Focus on the Department of Neurosciences! A grant awarded to John T. Gale, PhD, aims to provide high speed and natural movements to prosthetic limbs, while a closer look at multiple sclerosis has been made possible by a grant to Richard Ransohoff, MD. Read Full Article