• Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice.
  Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR, Bauer PM
  PubMed:22194859 :: 2011

• Severe Asthma: Lessons Learned from the NHLBI Severe Asthma Research Program.
  Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW
  PubMed:22095547 :: 2011

• Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.
  Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, Erzurum SC, Aldred MA
  PubMed:21920918 :: 2011

• High levels of zinc-protoporphyrin identify iron metabolic abnormalities in pulmonary arterial hypertension.
  Decker I, Ghosh S, Comhair SA, Farha S, Tang WH, Park M, Wang S, Lichtin AE, Erzurum SC
  PubMed:21884511 :: 2011

• Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation.
  Gangopahyay A, Oran M, Bauer EM, Wertz JW, Comhair SA, Erzurum SC, Bauer PM
  PubMed:21808054 :: 2011

• Detrimental effects of environmental tobacco smoke in relation to asthma severity.
  Comhair SA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Teague WG, Meyers D, Ampleford EJ, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, Jarjour WN, Moore W, Peters SP, Wenzel S, Hazen SL, Erzurum SC,
  PubMed:21572527 :: 2011

• Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children.
  Wedes SH, Wu W, Comhair SA, McDowell KM, DiDonato JA, Erzurum SC, Hazen SL
  PubMed:21392781 :: 2011

• Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.
  Farha S, Asosingh K, Xu W, Sharp J, George D, Comhair S, Park M, Tang WH, Loyd JE, Theil K, Tubbs R, Hsi E, Lichtin A, Erzurum SC
  PubMed:21258008 :: 2011

• Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program.
  Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW, Castro M, Gaston B, Israel E, Schwartz LB, Curran-Everett D, Moore CG, Wenzel SE
  PubMed:20813890 :: 2011

• Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
  Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD
  PubMed:20581168 :: 2010

• Noninvasive markers of airway inflammation in asthma.
  Wedes SH, Khatri SB, Zhang R, Wu W, Comhair SA, Wenzel S, Teague WG, Israel E, Erzurum SC, Hazen SL
  PubMed:20234847 :: 2009

• Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma.
  Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC,
  PubMed:20133930 :: 2010

• Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells.
  Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM
  PubMed:20110409 :: 2011

• Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.
  Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER,
  PubMed:19892860 :: 2010

• Redox control of asthma: molecular mechanisms and therapeutic opportunities.
  Comhair SA, Erzurum SC
  PubMed:19634987 :: 2010

• Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells.
  Chambellan A, Leahy R, Xu W, Cruickshank PJ, Janocha A, Szabo K, Cannady SB, Comhair SA, Erzurum SC
  PubMed:19135542 :: 2009

• Airway smooth muscle cells synthesize hyaluronan cable structures independent of inter-alpha-inhibitor heavy chain attachment.
  Lauer ME, Fulop C, Mukhopadhyay D, Comhair S, Erzurum SC, Hascall VC
  PubMed:19075022 :: 2009

• High levels of hyaluronan in idiopathic pulmonary arterial hypertension.
  Aytekin M, Comhair SA, de la Motte C, Bandyopadhyay SK, Farver CF, Hascall VC, Erzurum SC, Dweik RA
  PubMed:18776053 :: 2008

• Deficiency of lung antioxidants in idiopathic pulmonary arterial hypertension.
  Masri FA, Comhair SA, Dostanic-Larson I, Kaneko FT, Dweik RA, Arroliga AC, Erzurum SC
  PubMed:20443830 :: 2008

• Alterations of the arginine metabolome in asthma.
  Lara A, Khatri SB, Wang Z, Comhair SA, Xu W, Dweik RA, Bodine M, Levison BS, Hammel J, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Peters SP, Teague WG, Wenzel S, Hazen SL, Erzurum SC,
  PubMed:18635886 :: 2008

• Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension.
  Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SA, Xu W, Licina L, Huang L, Anand-Apte B, Yoder MC, Tuder RM, Erzurum SC
  PubMed:18258847 :: 2008

• Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.
  Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D
  PubMed:18042827 :: 2008

• Signal transduction and oxidative processes in sinonasal polyposis.
  Cannady SB, Batra PS, Leahy R, Citardi MJ, Janocha A, Ricci K, Comhair SA, Bodine M, Wang Z, Hazen SL, Erzurum SC
  PubMed:17935768 :: 2007

• Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
  Masri FA, Xu W, Comhair SA, Asosingh K, Koo M, Vasanji A, Drazba J, Anand-Apte B, Erzurum SC
  PubMed:17526595 :: 2007

• Cystic fibrosis and normal human airway epithelial cell response to influenza a viral infection.
  Xu W, Zheng S, Goggans TM, Kiser P, Quinones-Mateu ME, Janocha AJ, Comhair SA, Slee R, Williams BR, Erzurum SC
  PubMed:16978065 :: 2006

• Gene expression profile of human airway epithelium induced by hyperoxia in vivo.
  Chambellan A, Cruickshank PJ, McKenzie P, Cannady SB, Szabo K, Comhair SA, Erzurum SC
  PubMed:16690988 :: 2006

• Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis.
  Peikert T, Specks U, Farver C, Erzurum SC, Comhair SA
  PubMed:16651421 :: 2006

• Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.
  Ghosh S, Janocha AJ, Aronica MA, Swaidani S, Comhair SA, Xu W, Zheng L, Kaveti S, Kinter M, Hazen SL, Erzurum SC
  PubMed:16622028 :: 2006

• Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic.
  Masini E, Bani D, Vannacci A, Pierpaoli S, Mannaioni PF, Comhair SA, Xu W, Muscoli C, Erzurum SC, Salvemini D
  PubMed:16043023 :: 2005

• Abnormalities in nitric oxide and its derivatives in lung cancer.
  Masri FA, Comhair SA, Koeck T, Xu W, Janocha A, Ghosh S, Dweik RA, Golish J, Kinter M, Stuehr DJ, Erzurum SC, Aulak KS
  PubMed:15947282 :: 2005

• Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma.
  Comhair SA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, Gaston B, Hastie A, Hew M, Jarjour N, Moore W, Peters S, Teague WG, Wenzel SE, Erzurum SC
  PubMed:15883124 :: 2005

• Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.
  Comhair SA, Xu W, Ghosh S, Thunnissen FB, Almasan A, Calhoun WJ, Janocha AJ, Zheng L, Hazen SL, Erzurum SC
  PubMed:15743779 :: 2005

• The regulation and role of extracellular glutathione peroxidase.
  Comhair SA, Erzurum SC
  PubMed:15650397 :: 2005

• Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension.
  Xu W, Kaneko FT, Zheng S, Comhair SA, Janocha AJ, Goggans T, Thunnissen FB, Farver C, Hazen SL, Jennings C, Dweik RA, Arroliga AC, Erzurum SC
  PubMed:15364894 :: 2004

• Oxidative and nitrosative events in asthma.
  Andreadis AA, Hazen SL, Comhair SA, Erzurum SC
  PubMed:12885584 :: 2003

• STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation.
  Xu W, Comhair SA, Zheng S, Chu SC, Marks-Konczalik J, Moss J, Haque SJ, Erzurum SC
  PubMed:12788789 :: 2003

• Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis.
  Zheng S, De BP, Choudhary S, Comhair SA, Goggans T, Slee R, Williams BR, Pilewski J, Haque SJ, Erzurum SC
  PubMed:12753739 :: 2003

• Antioxidant responses to oxidant-mediated lung diseases.
  Comhair SA, Erzurum SC
  PubMed:12114185 :: 2002

• Differential expression of manganese superoxide dismutase and catalase in lung cancer.
  Chung-man Ho J, Zheng S, Comhair SA, Farver C, Erzurum SC
  PubMed:11731445 :: 2001

• Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species.
  MacPherson JC, Comhair SA, Erzurum SC, Klein DF, Lipscomb MF, Kavuru MS, Samoszuk MK, Hazen SL
  PubMed:11313420 :: 2001

• NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response.
  Dweik RA, Comhair SA, Gaston B, Thunnissen FB, Farver C, Thomassen MJ, Kavuru M, Hammel J, Abu-Soud HM, Erzurum SC
  PubMed:11226289 :: 2001

• Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells.
  Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC
  PubMed:11149894 :: 2001

• Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke.
  Comhair SA, Thomassen MJ, Erzurum SC
  PubMed:10970826 :: 2000

• Interleukin-9 receptor expression in asthmatic airways In vivo.
  Bhathena PR, Comhair SA, Holroyd KJ, Erzurum SC
  PubMed:10871433 :: 2000

• Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis.
  Guo FH, Comhair SA, Zheng S, Dweik RA, Eissa NT, Thomassen MJ, Calhoun W, Erzurum SC
  PubMed:10820280 :: 2000

• Eosinophils generate brominating oxidants in allergen-induced asthma.
  Wu W, Samoszuk MK, Comhair SA, Thomassen MJ, Farver CF, Dweik RA, Kavuru MS, Erzurum SC, Hazen SL
  PubMed:10811853 :: 2000

• Rapid loss of superoxide dismutase activity during antigen-induced asthmatic response.
  Comhair SA, Bhathena PR, Dweik RA, Kavuru M, Erzurum SC
  PubMed:10696986 :: 2000

• Variant forms of DNA polymerase beta in primary lung carcinomas.
  Bhattacharyya N, Chen HC, Comhair S, Erzurum SC, Banerjee S
  PubMed:10433553 :: 1999

• Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease.
  Comhair SA, Lewis MJ, Bhathena PR, Hammel JP, Erzurum SC
  PubMed:10351926 :: 1999

• Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension.
  Kaneko FT, Arroliga AC, Dweik RA, Comhair SA, Laskowski D, Oppedisano R, Thomassen MJ, Erzurum SC
  PubMed:9731026 :: 1998

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro
M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun
WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23.

Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC. Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, At-risk Phenotype Among Patients With Asthma. Am J Respir Crit Care Med. 2010 Feb 4.

Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM. Hypoxia Inducible-Factor1{alpha} Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells. Am J Pathol. 2010 Jan 28.

Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2010 Jan;12(1):93-124.

Chambellan A, Leahy R, Xu W, Cruickshank PJ, Janocha A, Szabo K, Cannady SB, Comhair SA, Erzurum SC. Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells. Nitric Oxide. 2009 May;20(3):143-9.

Lauer ME, Fulop C, Mukhopadhyay D, Comhair S, Erzurum SC, Hascall VC. Airway smooth muscle cells synthesize hyaluronan "cable" structures independent of inter-alpha-inhibitor heavy chain attachment. J Biol Chem. Dec 15, 2008.

Aytekin M, Comhair SA, de la Motte C, Bandyopadhyay SK, Farver CF, Hascall VC, Erzurum SC, Dweik RA. High levels of hyaluronan in idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. Nov;295(5):L789-99, 2008.

Lara A, Khatri SB, Wang Z, Comhair SA, Xu W, Dweik RA, Bodine M, Levison BS, Hammel J, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Erzurum SC. Alterations of the Arginine Metabolome in Asthma. Am J Respir Crit Care Med. Oct 1;178(7):673-81, 2008.

Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SA, Xu W, Licina L, Huang L, Anand-Apte B, Yoder MC, Tuder RM, Erzurum SC. Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol. Mar;172(3):615-27, 2008.

Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D. Ceramide: A Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation. J Pharmacol Exp Ther. Feb;324(2):548-57, 2008.

Tobias Peikert, Ulrich Specks, Carol Farver, Serpil C. Erzurum and S A. A. Comhair. Melanoma antigen A4 (MAGEA4) promotes apoptosis in non-small cell lung cancers. Cancer Res. May 1;66(9):4693-700, 2006. Sudakshina Ghosh, Allison J. Janocha, Mark A. Aronica, Shadi Swadani, S A. A. Comhair, Weiling Xu, Lemin Zheng, Michael T. Kinter, Stanley L. Hazen and Serpil C. Erzurum. Nitrotyrosine proteome survey in experimental asthma identifies oxidative modifications and catalase inactivation in asthma pathophysiology. J. Immunology. May 1,176(9):5587-97, 2006.

Comhair S.A.A., Kristin S. Ricci, Mercedes Arroliga, Abigail R. Lara, Raed A. Dweik, Wei Song, Stanley L. Hazen, Eugene R. Bleecker, William W. Busse, Kian F. Chung, Benjamin Gaston, Annette Hastie, Mark Hew, Nizar Jarjour, Wendy Moore, Stephen Peters, W Gerald Teague, Sally E. Wenzel and Serpil C. Erzurum for the National Heart, Lung and Blood Institute’s Severe Asthma Research Program. Asthma Severity Related to Systemic Deficiency of Superoxide Dismutase. Am J. Respir. Crit. Care Med. Aug 1;172(3):306-13, 2005.

Comhair S.A.A, Xu Weiling, Ghosh Sudakshina, , Thunnissen F.B.J.M, Calhoun W.J., Almason A, Janocha A.J, Zheng L,. Hazen S.L and Erzurum S.C. Superoxide Dismutase Inactivation In Pathophysiology of Asthmatic Airway Remodeling and Reactivity. Am. J. Path. Mar;166(3):663-74, 2005.

Xu W, Kaneko FT, Zheng S, Comhair SAA, Janocha AJ, Goggans T, Thunnissen FB, Farver C, Hazen SL, Jennings C, Dweik RA, Arroliga AC, Erzurum SC. Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J. Nov;18(14):1746-8, 2004.

Xu W., Comhair S.A.A., Zheng S., Chu S.C., Marks-Konczalik J., Moss J, Haque S.J., Erzurum S.C. Cooperative Transcription Activation of Nitric Oxide Synthase 2 Trough STAT-1 and c-Fos Interaction. Am. J. Physiol. Vol 285(1): L137-48. 2003.

Zheng S, De BP, Choudhary S, Comhair SA, Goggans T, Slee R, Williams BR, Pilewski J, Haque SJ, Erzurum SC. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity Vol 18 (5): 619-630, 2003.

Dweik A.R., Comhair S.A.A., Gaston B., Thunnissen F.B.J.M., Farver C., Thomassen M. J., Kavuru M., Hammel J., Abu-Soud H. M., and Erzurum S.C. Nitric Oxide chemical events in the human airway during the immediate and late antigen induced asthmatic response. PNAS Vol 98: 2622-2627, 2001.

Comhair S.A.A., Bhathena P, Farver C., Thunnissen F.B.J.M., Erzurum S.C. Extracellular glutahione peroxidase induction in asthmatic lungs: Evidence for redox regulation of expression in human airway epithelial cells. FASEB J. Vol 15: 70-78, 2001.

Comhair S.A.A., Thomassen M.J., Erzurum S.C. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O2 or cigarette smoke. Am. J. Respir. Cell Mol. Biol. Vol 23: 350-354, 2000.

Comhair S.A.A., Bhathena P, Dweik R.A, Kavuru M., Erzurum S.C. Rapid Loss of superoxide dismutase activity during antigen-induced asthmatic response. Lancet. Vol 355: 624, 2000.

Comhair S.A.A., Lewis M. J., Bhathena P. R., and Erzurum S.C. Increased Glutathione and Glutathione Peroxidase in Lungs of Individuals with Chronic beryllium disease. Am. J. Respir. Crit. Care Med. Vol 159: 1824-1829, 1999.