Key References:
Fiocchi C. Susceptibility genes and overall pathogenesis of inflammatory bowel
disease: where do we stand? Dig Dis. 2009;27(3):226-35. Review. PDF
Im E, Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH. The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. Am J Physiol Gastrointest Liver Physiol. 2009 Sep 3. PDF
de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64. PDF
Achkar JP, Fiocchi C. Gene-Gene Interactions in Inflammatory Bowel Disease: Biological and Clinical Implications. Am J Gastroenterol. 2009 May 12. PDF
de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64. PDF
Rieder F, Fiocchi C. Intestinal fibrosis in IBD--a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol. 6(4):228-35. 2009 PDF
Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Silvio D. VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis. Gastroenterology. 136(2):585-95.e5. 2009 PDF
Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol. 24(4):462-8, 2008. PDF
Fiocchi C. Future of IBD pathogenesis: How much work is left to do? Inflamm Bowel Dis. 14(S2):S145-S147, 2008. PDF
Fiocchi C. What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation? Inflamm Bowel Dis. 14(S2):S77-S78, 2008. PDF
Sturm A, de Souza HS, Fiocchi C. Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr Drug Targets. 9(5):381-7. Review, 2008.
Scaldaferri F, Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J Dig Dis. 8(4):171-8. Review, 2007. PDF
Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 56(12):1696-705, 2007. PDF
Kugathasan S, Fiocchi C. Progress in basic inflammatory bowel disease research. Semin Pediatr Surg. 16(3):146-53. Review, 2007. PDF
Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C. Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology 132:154-165, 2007. PDF
Sans M, Danese S, De La Motte C, de Souza HSP, Rivera-Reyes BM, West GA, Phillips M, Katz JA, Fiocchi C. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 132:139-153, 2007. PDF
Danese S, et al. Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut 2007;56:1248-56. PDF
Danese S, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007;56:855-62. PDF
Danese S, Dejana E, Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 2007;178:6017-22. PDF
Fiocchi C. Probiotics in inflammatory bowel disease: yet another mechanism of action? Gastroenterology 131:2009-2012, 2006. PDF
Danese S, Fiocchi C. The etiopathogenesis of inflammatory bowel diseases. World J Gastroenterology 14:4807-4812, 2006. PDF
Danese S, Sans, M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rivera-Reyes BM, Willis J, Gasbarrini A, Fiocchi C. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130:2060-2073, 2006. PDF
Fiocchi C. One commensal bacterial molecule - All we need for health? N Engl J Med 353:2078-2080, 2005. PDF
Ina K, Kusugami K, Kawano Y, Nishiwaki T, Wen Z, Musso A, West GA, Ohta M, Goto H, Fiocchi C. Intestinal fibroblast-derived IL-10 increases survival of mucosal T-cells by inhibiting growth factor deprivation- and Fas-mediated apoptosis. J Immunol 175:2000-2009, 2005. PDF
Fiocchi C. Closing fistulas in Crohn's disease - Should the accent be on maintenance or safety? N Engl J Med 350:934-936, 2004. PDF
Sturm A, Leite AZ, Danese S, Krivacic KA, West GA, Mohr S, Jacobberger JW, Fiocchi C. Divergent cell cycle kinetics underlie the pathogenesis of chronic inflammatory diseases. Gut 53:1624-1631, 2004. PDF
Vogel JD, West GA. Danese S, de la Motte C, Phillips MH, Strong SA, Willis J, Fiocchi C. CD40-mediated immune-nonimmune cell interactions trigger mucosal fibroblast chemokine production causing T-cell transmigration. Gastroenterology 126:63-80, 2004. PDF
Lawrance IC, Wu F, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis. Gastroenterology 125:1750-1761, 2003. PDF
Danese S, de la Motte C, Sturm A, West GA, Strong SA, Katz JA, Fiocchi C. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 124:1249-1264, 2003.
Sturm A, Itoh J, Jacobberger JW, Fiocchi C. p53 acts as a negative regulator of intestinal immunity by delaying the cell cycle kinetics of mucosal T-cells. J Clin Invest 109:1481-1492, 2002. PDF