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Fred Hsieh, M.D.Associate StaffDepartment of Pathobiology |
Area of general research interest:
Effector cell function in allergic inflammation
Current programs:
- Mast cell: airway epithelial cell interactions in mucosal inflammation
- Tyrosine kinase inhibition in the treatment of mast cell disorders
Investigators:
- Hary T. Katz, M.D.
Collaborators:
- Serpil C. Erzurum, M.D., Chair, Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH.
- S. Jahar Haque, Ph.D., Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH.
- Alan E. Lichtin, M.D., Hematology and Oncology, The Cleveland Clinic Foundation, Cleveland, OH.
Brief Description:
Our laboratory is interested in studying the development and function of the mast cell in human diseases, with special emphasis on the contribution of mast cells to allergic pulmonary inflammation.
One current focus is the study of mast-cell tissue heterogeneity to understand the determinants of the reactive mucosal mast-cell phenotype as defined in a model of mast-cell/airway epithelial cell coculture.
Our hope is that by understanding the mechanisms by which mast cells are primed to react at airway mucosal surfaces, we will be able to develop therapeutics that specifically target the mast cells that participate in airway inflammation without interrupting the contribution of mast cells to normal physiologic processes.
Key References:
Sheffer AL, Arm J, Boyce J, Castells M, Greineder D, Horan R, Hsieh F . Allergy. JAMA 1999; 281 :1955. PDF
Ochi H, DeJesus NH. Hsieh FH , Austen KF, Boyce JA. IL-4 and IL-5 prime human mast cells for different profiles of IgE-dependent cytokine production . Proc Natl Acad Sci USA 2000; 97 :10509-10513. PDF
Hsieh FH , Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate IgE-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C4 synthase expression by IL-4. J Exp Med 2001; 193:123-133. PDF
Hsieh FH , Bingham CO III, Austen KF. Molecular and Cellular Biology of the Mast Cell.in : Dermatology in General Medicine , 6th edition, McGraw Hill, 2003, 330-335.
Markman M, Hsieh F , Zanotti K, Webster K, Peterson G, Kulp B, Spicel A, Belinson J. Initial experience with a novel desensitization strategy for carboplatin-associated hypersensitivity reactions: carboplatin-hypersensitivity reactions. J Cancer Res Clin Oncol 2004; 130:25-28. PDF
Katz HT, Haque SJ, Hsieh FH. Pediatric hypereosinophilic syndrome (HES) differs from adult HES. J Pediatr. 2005; Jan; 146(1):134-6. Review. PDF
Hsieh FH, Sharma P, Gibbons A, Goggans T, Erzurum SC, Haque SJ. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc Natl Acad Sci U S A. 2005; Oct 4; 102(40):14380-5 PDF
Zuluaga Toro T, et al. Detection of phospho-STAT5 in mast cells: a reliable phenotypic marker of systemic mast cell disease that reflects constitutive tyrosine kinase activation. Br J Haematol 2007;139:31-40. PDF