John P. Kirwan, Ph.D.

John P. Kirwan, Ph.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: (216) 444-3412
  • Fax: (216)636-0104
  • Email:
  • Dr. Kirwan Lab


See all publications on PubMed

Bariatric Surgery in Obese Patients With Type 1 Diabetes. Kirwan JP, Aminian A, Kashyap SR, Burguera B, Brethauer SA, Schauer PR. Diabetes Care. 2016 Jun;39(6):941-8. doi: 10.2337/dc15-2732. Review. PMID: 27222552

The effect of pregnancy before and/or after bariatric surgery on weight loss. Froylich D, Corcelles R, Daigle CR, Kirwan JP, Brethauer SA, Schauer PR. Surg Obes Relat Dis. 2016 Mar-Apr;12(3):596-9. doi: 10.1016/j.soard.2015.09.005. Epub 2015 Sep 24. PMID: 27174246

Longer-Term Physiological and Metabolic Effects of Gastric Bypass Surgery. Mosinski JD, Kirwan JP. Curr Diab Rep. 2016 Jun;16(6):50. doi: 10.1007/s11892-016-0747-1. Review.
PMID: 27091444

Short-term aerobic exercise training improves gut peptide regulation in nonalcoholic fatty liver disease. Kullman EL, Kelly KR, Haus JM, Fealy CE, Scelsi AR, Pagadala MR, Flask CA, McCullough AJ, Kirwan JP. J Appl Physiol (1985). 2016 May 15;120(10):1159-64. doi: 10.1152/japplphysiol.00693.2015. Epub 2016 Mar 31. PMID: 27032902

Body mass index and causes of death in chronic kidney disease. Navaneethan SD, Schold JD, Arrigain S, Kirwan JP, Nally JV Jr. Kidney Int. 2016 Mar;89(3):675-82. doi: 10.1016/j.kint.2015.12.002. Epub 2016 Jan 12. PMID: 26880461

A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake. Ross AB, Svelander C, Savolainen OI, Lind MV, Kirwan JP, Breton I, Godin JP, Sandberg AS. Anal Biochem. 2016 Apr 15;499:1-7. doi: 10.1016/j.ab.2015.12.023. Epub 2016 Jan 28. PMID: 26827992

Gastric bypass surgery is protective from high-fat diet-induced non-alcoholic fatty liver disease and hepatic endoplasmic reticulum stress. Mosinski JD, Pagadala MR, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Pai RK, Schauer PR, Brethauer SA, Kirwan JP. Acta Physiol (Oxf). 2016 Jun;217(2):141-51. doi: 10.1111/apha.12640. Epub 2015 Dec 29. PMID: 26663034

A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis. Nock NL, Owusu C, Flocke S, Krejci SA, Kullman EL, Austin K, Bennett B, Cerne S, Harmon C, Moore H, Vargo M, Hergenroeder P, Malone H, Rocco M, Tracy R, Lazarus HM, Kirwan JP, Heyman E, Berger NA. Int J Sports Exerc Med. 2015;1(3). pii: 020. Epub 2015 Sep 5. PMID: 26640827

A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease. Navaneethan SD, Fealy CE, Scelsi AC, Arrigain S, Malin SK, Kirwan JP. Am J Nephrol. 2015;42(4):274-81. doi: 10.1159/000441155. Epub 2015 Oct 24. PMID: 26495987

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. Mocanu AO, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, Brethauer SA, Dinischiotu A, Kirwan JP. PLoS One. 2015 Oct 5;10(10):e0139764. doi: 10.1371/journal.pone.0139764. eCollection 2015. PMID: 26437377

Two-year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy. Maghrabi AH, Wolski K, Abood B, Licata A, Pothier C, Bhatt DL, Nissen S, Brethauer SA, Kirwan JP, Schauer PR, Kashyap SR. Obesity (Silver Spring). 2015 Dec;23(12):2344-8. doi: 10.1002/oby.21150. Epub 2015 Jul 20. PMID: 26193177

Failed Surgical Weight Loss Does Not Necessarily Mean Failed Metabolic Effects. Aminian A, Jamal M, Augustin T, Corcelles R, Kirwan JP, Schauer PR, Brethauer SA. Diabetes Technol Ther. 2015 Oct;17(10):682-4. doi: 10.1089/dia.2015.0064. Epub 2015 Jul 15. PMID: 26177379

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes. Kasumov T, Solomon TP, Hwang C, Huang H, Haus JM, Zhang R, Kirwan JP. Obesity (Silver Spring). 2015 Jul;23(7):1414-21. doi: 10.1002/oby.21117. Epub 2015 May 12. PMID: 25966363


  • Fellowship - Washington University School of Medicine
    Internal Medicine – Applied Physiology and Metabolism
    St Louis, MO
  • Doctorate - Ball State University
    Human Bioenergetics
    Muncie, IN
  • Graduate - University of Massachusetts
    Exercise Biochemistry
    Amherst, MA
  • Undergraduate - University of Limerick
    Limerick, Ireland
  • Diabetes
  • Obesity/Bariatric Surgery
  • Nutrition
  • Exercise

  • Pregnancy
  • Liver Disease