John P. Kirwan, Ph.D.

John P. Kirwan, Ph.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: (216) 444-3412
  • Fax: (216)636-0104
  • Email:
  • Dr. Kirwan Lab


See all publications on PubMed.


Two-year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy.

Maghrabi AH, Wolski K, Abood B, Licata A, Pothier C, Bhatt D, Nissen S, Brethauer SA, Kirwan JP, Schauer PR, Kashyap SR.

Obesity (Silver Spring). 2015 Jul 20. doi: 10.1002/oby.21150. [Epub ahead of print]

PMID: 26193177

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Failed Surgical Weight Loss Does Not Necessarily Mean Failed Metabolic Effects.

Aminian A, Jamal M, Augustin T, Corcelles R, Kirwan JP, Schauer PR, Brethauer SA.

Diabetes Technol Ther. 2015 Jul 15. [Epub ahead of print]

PMID: 26177379

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Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.

Kasumov T, Li L, Li M, Gulshan K, Kirwan JP, Liu X, Previs S, Willard B, Smith JD, McCullough A.

PLoS One. 2015 May 20;10(5):e0126910. doi: 10.1371/journal.pone.0126910. eCollection 2015.

PMID: 25993337 Free PMC Article

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Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes.

Kasumov T, Solomon TP, Hwang C, Huang H, Haus JM, Zhang R, Kirwan JP.

Obesity (Silver Spring). 2015 Jul;23(7):1414-21. doi: 10.1002/oby.21117. Epub 2015 May 12.

PMID: 25966363

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Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum.

Solomon TP, Malin SK, Karstoft K, Knudsen SH, Haus JM, Laye MJ, Kirwan JP.

Diabetes Care. 2015 May;38(5):921-9. doi: 10.2337/dc14-2813. Epub 2015 Mar 17.

PMID: 25784661

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Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation.

Malin SK, Kirwan JP, Sia CL, González F.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E770-7. doi: 10.1152/ajpendo.00510.2014. Epub 2015 Feb 24.

PMID: 25714674

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Serum levels of retinol-binding protein 4 and risk of colon adenoma.

Abola MV, Thompson CL, Chen Z, Chak A, Berger NA, Kirwan JP, Li L.

Endocr Relat Cancer. 2015 Apr;22(2):L1-4. doi: 10.1530/ERC-14-0429. No abstract available.

PMID: 25712946 Free PMC Article

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Adults with long-duration type 2 diabetes have blunted glycemic and β-cell function improvements after bariatric surgery.

Khanna V, Malin SK, Bena J, Abood B, Pothier CE, Bhatt DL, Nissen S, Watanabe R, Brethauer SA, Schauer PR, Kirwan JP, Kashyap SR.

Obesity (Silver Spring). 2015 Mar;23(3):523-6. doi: 10.1002/oby.21021. Epub 2015 Feb 3.

PMID: 25651277

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Exploring the impact of bariatric surgery on high density lipoprotein.

Aminian A, Zelisko A, Kirwan JP, Brethauer SA, Schauer PR.

Surg Obes Relat Dis. 2015 Jan-Feb;11(1):238-47. doi: 10.1016/j.soard.2014.07.017. Epub 2014 Aug 11. Review.

PMID: 25547050

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Bariatric surgery, kidney function, insulin resistance, and adipokines in patients with decreased GFR: a cohort study.

Navaneethan SD, Malin SK, Arrigain S, Kashyap SR, Kirwan JP, Schauer PR.

Am J Kidney Dis. 2015 Feb;65(2):345-7. doi: 10.1053/j.ajkd.2014.09.018. Epub 2014 Nov 18. No abstract available.

PMID: 25458664

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How safe is metabolic/diabetes surgery?

Aminian A, Brethauer SA, Kirwan JP, Kashyap SR, Burguera B, Schauer PR.

Diabetes Obes Metab. 2015 Feb;17(2):198-201. doi: 10.1111/dom.12405. Epub 2014 Nov 19.

PMID: 25352176

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Response to comments on Brethauer et al. Bariatric surgery improves the metabolic profile of morbidly obese patients with type 1 diabetes. Diabetes care 2014;37:e51-e52.

Kirwan JP, Brethauer SA, Aminian A, Rosenthal RJ, Kashyap SR, Schauer PR.

Diabetes Care. 2014 Nov;37(11):e251. doi: 10.2337/dc14-1769. No abstract available.

PMID: 25342846

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  • Fellowship - Washington University School of Medicine
    Internal Medicine – Applied Physiology and Metabolism
    St Louis, MO
  • Doctorate - Ball State University
    Human Bioenergetics
    Muncie, IN
  • Graduate - University of Massachusetts
    Exercise Biochemistry
    Amherst, MA
  • Undergraduate - University of Limerick
    Limerick, Ireland
  • Diabetes
  • Obesity/Bariatric Surgery
  • Nutrition
  • Exercise

  • Pregnancy
  • Liver Disease