John P. Kirwan, Ph.D.

John P. Kirwan, Ph.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: (216) 444-3412
  • Fax: (216)636-0104
  • Email:
  • Fellowship - Washington University School of Medicine
    Internal Medicine – Applied Physiology and Metabolism
    St Louis, MO
  • Doctorate - Ball State University
    Human Bioenergetics
    Muncie, IN
  • Graduate - University of Massachusetts
    Exercise Biochemistry
    Amherst, MA
  • Undergraduate - University of Limerick
    Limerick, Ireland
  • Exercise physiology
  • Insulin resistance
  • Metabolic Syndrome
  • Obesity
  • Diabetes
  • Bariatric Surgery
  • Aging

PubMed Publications

Kelly KR, Haus JM, Solomon TP, Patrick-Melin AJ, Cook M, Rocco M, Barkoukis H, Kirwan JP (Apr 2011) A Low-Glycemic Index Diet and Exercise Intervention Reduces TNF{alpha} in Isolated Mononuclear Cells of Older, Obese Adults., The Journal of nutrition Abstract

Brethauer SA, Heneghan HM, Eldar S, Gatmaitan P, Huang H, Kashyap S, Gornik HL, Kirwan JP, Schauer PR (Mar 2011) Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patients., Surgical endoscopy Abstract

Solomon TP, Haus JM, Li Y, Kirwan JP (Feb 2011) Progressive Hyperglycemia across the Glucose Tolerance Continuum in Older Obese Adults Is Related to Skeletal Muscle Capillarization and Nitric Oxide Bioavailability., The Journal of clinical endocrinology and metabolism Abstract

Solomon TP, Haus JM, Kelly KR, Cook MD, Filion J, Rocco M, Kashyap SR, Watanabe RM, Barkoukis H, Kirwan JP (Dec 2010) A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans., The American journal of clinical nutrition, 92 (6), 1359-68 Abstract

Nock NL, Patrick-Melin A, Cook M, Thompson C, Kirwan JP, Li L (Oct 2010) Higher bone mineral density is associated with a decreased risk of colorectal adenomas., International journal of cancer. Journal international du cancer Abstract

Gatmaitan P, Huang H, Talarico J, Moustarah F, Kashyap S, Kirwan JP, Schauer PR, Brethauer SA (2010) Pancreatic islet isolation after gastric bypass in a rat model: technique and initial results for a promising research tool., Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 6 (5), 532-7 Abstract

Ghanbari-Niaki A, Saghebjoo M, Soltani R, Kirwan JP (Jul 2010) Plasma Visfatin Is Increased after High-Intensity Exercise., Annals of nutrition & metabolism, 57 (1), 3-8 Abstract

González F, Rote NS, Minium J, Weaver AL, Kirwan JP (Jul 2010) Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome., Cytokine Abstract

Kasumov T, Huang H, Chung YM, Zhang R, McCullough AJ, Kirwan JP. Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Biochem. 2010 Feb 21.

Solomon TP, Haus JM, Kelly KR, Rocco M, Kashyap SR, Kirwan JP. Improved Pancreatic Beta-Cell Function In Type 2 Diabetics Following Lifestyle-Induced Weight Loss Is Related To Glucose-Dependent Insulinotropic Polypeptide. Diabetes Care. 2010 Mar 3.

Li Y, Solomon TP, Haus JM, Saidel GM, Cabrera ME, Kirwan JP. Computational Model of Cellular Metabolic Dynamics: Effect of Insulin on Glucose Disposal in Human Skeletal Muscle. Am J Physiol Endocrinol Metab. 2010 Mar 23.

Kirwan JP Insulin Sensitivity In Skeletal Muscle - 'Use It Or Lose It, Fast'. J Appl Physiol. 2010 Feb 18.

McIntyre HD, Chang AM, Callaway LK, Cowley DM, Dyer AR, Radaelli T, Farrell KA, Huston-Presley L, Amini SB, Kirwan JP, Catalano PM; Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group. Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy. Diabetes Care. 2010 Feb;33(2):356-60.

Kelly KR, Williamson DL, Fealy CE, Kriz DA, Krishnan RK, Huang H, Ahn J, Loomis JL, Kirwan JP. Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans. Metabolism. 2010 Feb;59(2):200-5.

Haus JM, Solomon TP, Marchetti CM, Edmison JM, González F, Kirwan JP. Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance. J Clin Endocrinol Metab. 2010 Jan;95(1):323-7.

Radaelli T, Farrell KA, Huston-Presley L, Amini SB, Kirwan JP, McIntyre HD, Catalano PM. Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test. Diabetes Care. 2010 Mar;33(3):490-4.

Kashyap SR, Daud S, Kelly KR, Gastaldelli A, Win H, Brethauer S, Kirwan JP, Schauer PR. Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes. Int J Obes (Lond). 2010 Mar;34(3):462-71.

Navaneethan SD, Kelly KR, Sabbagh F, Schauer PR, Kirwan JP, Kashyap SR. Urinary Albumin Excretion, HMW Adiponectin, and Insulin Sensitivity in Type 2 Diabetic Patients Undergoing Bariatric Surgery. Obes Surg. 2009 Nov 20.

Solomon TP, Haus JM, Kelly KR, Cook MD, Riccardi M, Rocco M, Kashyap SR, Barkoukis H, Kirwan JP. Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans. Am J Clin Nutr. 2009 Nov;90(5):1222-9.

Kirwan JP, Barkoukis H, Brooks LM, Marchetti CM, Stetzer BP, Gonzalez F. Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults. Ann Nutr Metab. 2009;55(4):326-33.

Kelly KR, Kashyap SR, O'Leary VB, Major J, Schauer PR, Kirwan JP. Retinol-binding Protein 4 (RBP4) Protein Expression Is Increased in Omental Adipose Tissue of Severely Obese Patients. Obesity (Silver Spring). 2009 Oct 8.

Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP. Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E552-9.

Gonzalez, F., N.S. Rote, J. Minium, and J.P. Kirwan. Evidence of proatherogenic inflammation in polycystic ovary syndrome. Metabolism. Metabolism. 2009 Jul;58(7):954-62.

Haus, J.M., T.P. Solomon, C.M. Marchetti, L.M. Brooks, V.B. O’Leary, F. Gonzalez, and J.P. Kirwan. Decreased visfatin after exercise training correlates with improved glucose tolerance. Med. Sci. Sports Exerc. 41(6):1255-60,2009

Yassine, H., C.M. Marchetti, R.K. Krishnan, T.R. Vrobel, F. Gonzalez, and J.P. Kirwan. Effects of exercise and caloric restriction on insulin resistance, metabolic syndrome, and cardiovascular risk factors in older obese adults – a randomized clinical trial. J. Gerontol. A Biol. Sci. Med. Sci. 64: 90-95, 2009.

Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP. Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans. Am J Physiol Endocrinol Metab. 2009 Jun 16.

Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 Days of Exercise Training on Insulin Sensitivity and Responsiveness in Type 2 Diabetes Mellitus.Am J Physiol Endocrinol Metab. 2009 Apr 21.

Kelly KR, Brooks LM, Solomon TP, Kashyap SR, O'Leary VB, Kirwan JP. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1269-74.

Haus J.M., Kashyap S.R., Kasumov T., Zhang R., Kelly K.R., Defronzo R.A., and Kirwan J.P. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes. 58(2):337-43, 2009.

Solomon T.P., Sistrun S.N., Krishnan R.K., Del Aguila L.F., Marchetti C.M., O'Carroll S.M., O'Leary V.B., and Kirwan J.P. Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol. 104(5):1313-9, 2008.

Friedman, J.E., J.P. Kirwan, M. Jing, L. Presley, and P.M. Catalano. Increased skeletal muscle TNF-a and impaired insulin signaling persists in obese GDM women 1 year postpartum. Diabetes. 57:606-13, 2008.

Solomon TP, Marchetti CM, Krishnan RK, Gonzalez F, Kirwan JP. Effects of aging on basal fat oxidation in obese humans. Metabolism. 57(8): 1141-7, 2008.

O’Leary, V.B., A.E. Nardi, C.M. Marchetti, F. Gonzalez, S.A. Phillips, T.P. Ciaraldi, and J.P. Kirwan. Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin resistant adults. Am. J. Physiol. Endocrinol. Metab. 293: E421-E427, 2007.

Barbour, L.A., C.E. McCurdy, T.L. Hernandez, J.P. Kirwan, P.M. Catalano, and J.E. Friedman. Cellular mechanisms of insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. Suppl 2: S112-S119, 2007.

Hakimi, P., J. Yang, G. Casadesus, D. Massillon, F. Tolentino-Silva, C.K. Nye, M.E. Cabrera, D.R. Hagen, C.B. Utter, Y. Baghdy, D.H. Johnson, D.L. Wilson, J.P. Kirwan, S.C. Kalhan, and R.W. Hanson. Over-expression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J. Biol. Chem. 282: 32844-55, 2007.

Gonzalez, F., N.S. Rote, J. Minium, V.B. O’Leary, and J.P. Kirwan. Obese reproductive age women exhibit a proatherogenic inflammatory response to hyperglycemia. Obesity. 15: 2436-2444, 2007.

Barkoukis, H, C.M. Marchetti, B. Nolan, S.N. Sistrun, R.K. Krishnan, and J.P. Kirwan. A high glycemic meal suppresses the postprandial leptin response in normal healthy adults. Ann. Nutr. Metab. 51: 512-518, 2007.

O’Leary, V.B., C.M. Marchetti, R.K. Krishnan, B.P. Stetzer, F. Gonzalez, and J.P. Kirwan. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J. Appl. Physiol. 100: 1584-1589, 2006.

O’Connor, A.M., S. Pola, B.M. Ward, D. Fillmore, K.D. Buchanan, and J.P. Kirwan. The gastroenteroinsular response to glucose ingestion during postexercise recovery. Am. J. Physiol. Endocrinol. Metab. 290: E1155-1161, 2006.