Dr. Laura E. Nagy Lab

Laura E. Nagy, Ph.D.

Staff, Department of Pathobiology

The research in my laboratory is aimed at understanding how chronic alcohol consumption contributes to chronic diseases, such as liver disease and diabetes.

The research in my laboratory is aimed at understanding how chronic alcohol consumption contributes to chronic diseases, such as liver disease and diabetes.

Research Projects

  • Studying the effects of ethanol on the innate immune system
  • Understanding how ethanol disrupts signal transduction via the toll-like receptors, leading to disruption of the transcriptional and post-transcriptional regulation of cytokine production
  • Investigating how ethanol causes insulin resistance in adipose tissue, leading to impaired GLUT4 vessicle trafficking and glucose transport, as well as abnormal regulation of triglyceride homeostasis.
  • Mark Barnes, B.S.
  • Katelyn Bush, B.S.
  • Dian Chiang, M.D.
  • Gail Cresci, Ph.D., R.D., L.D., C.N.S.D.
  • Jazmine Danner, B.A.
  • Dola Das, Ph.D.
  • Megan McMullen, B.A.
  • Katherine Ann Pollard, B.S.
  • Sanjoy Roychowdhury, Ph.D.
  • Becky Smathers, Ph.D.
  • National Institutes of Health
    - Regulation of Kupffer cell signal transduction by ethanol
    This project investigates the effects of chronic ethanol on Kupffer cell dependent signal transduction.
  • National Institutes of Health
    - Insulin mediated glucose transport: disruption by ethanol
    This project investigates the effects of chronic ethanol on regulation of glucose transport in adipocytes and muscles.
  • National Institutes of Health
    - Egr-1: A candidate molecular target of ethanol action
    This project explores the role of the transcription factor, Egr-1, in the development of alcoholic liver injury.
  • National Institutes of Health
    - Egr-1 and EtOH-induced hepatic leukocyte recruitment
    NRSA fellowship to Michele T. Pritchard
  • National Institutes of Health
    - Complement and liver injury
    This project investigates the contribution of complement activation in ethanol-induced liver injury.
  • National Institutes of Health
    - Thioredoxin and ethanol-induced liver injury
    NRSA fellowship to Jessica Cohen