Coming to cancer research from process control engineering, I decided to focus on hematologic malignancies because, given the accessibility of blood, cancer state feedback should be richest for such cancers. I then decided to focus on chronic myeloid leukemia (CML) because it is simple. Indeed, the better a process is understood, the easier it is to control. CML is now solved, but the solution is expensive. Moving forward, my goal is to see if it can be prevented.
In other words ...
I hope to produce mathematical models that will improve our control of myeloid cancers.
Radivoyevitch, T., Kozubek, S. and Sachs, R. K., Biologically based risk estimation for radiation-induced CML. Inferences from BCR and ABL geometric distributions. Radiat Environ Biophys40, 1-9 (2001).
Radivoyevitch, T., Li, H., and Sachs, R.K. Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models. In A Systems Biology Approach to Blood (S. J. Corey, M. Kimmel and J. N. Leonard, Editors), Springer. Adv Exp Med Biol 844, 317-46 (2014).
Radivoyevitch T, Jankovic GM, Tiu RV, Saunthararajah Y, Jackson RC, Hlatky LR, Gale RP, Sachs RK. Sex differences in the incidence of chronic myeloid leukemia. Radiat Environ Biophys.53(1):55-63 (2014)
Radivoyevitch, T., Sachs, R.K., Gale, R.P., Molenaar, R.J., Brenner, D.J., Hill, B.T., Kalaycio, M.E., Carraway, H.E., Mukherjee, S., Sekeres, M.A. & Maciejewski, J.P. Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation. Leukemia 30(2):285-94 (2016).
Radivoyevitch, T., Sachs, R.K., Gale, R.P., Smith, M.R. & Hill, B.T. Ionizing radiation exposures in treatments of solid neoplasms are not associated with subsequent increased risks of chronic lymphocytic leukemia. Leuk Res43, 9-12 (2016).
Radivoyevitch, T., Dean, R.M., Shaw, B.E., Brazauskas, R., Tecca, H.R., Molenaar, R.J., Battiwalla, M., Savani, B.N., Flowers, M.E.D., Cooke, K.R., Hamilton, B.K., Kalaycio, M., Maciejewski, J.P., Ahmed, I., Akpek, G., Bajel, A., Buchbinder, D., Cahn, J.Y., D'Souza, A., Daly, A., DeFilipp, Z., Ganguly, S., Hamadani, M., Hayashi, R.J., Hematti, P., Inamoto, Y., Khera, N., Kindwall-Keller, T., Landau, H., Lazarus, H., Majhail, N.S., Marks, D.I., Olsson, R.F., Seo, S., Steinberg, A., William, B.M., Wirk, B., Yared, J.A., Aljurf, M., Abidi, M.H., Allewelt, H., Beitinjaneh, A., Cook, R., Cornell, R.F., Fay, J.W., Hale, G., Chakrabarty, J.H., Jodele, S., Kasow, K.A., Mahindra, A., Malone, A.K., Popat, U., Rizzo, J.D., Schouten, H.C., Warwick, A.B., Wood, W.A., Sekeres, M.A., Litzow, M.R., Gale, R.P. & Hashmi, S.K. Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma. Leuk Res74, 130-136 (2018).
No news currently found.