Stem Cell Biology and Regenerative Medicine
Jeongwu Lee, Ph.D.
Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 444-9834
Fax: (216) 636-5454
My laboratory studies the biology of glioblastoma multiforme (GBM), the most aggressive subtype of brain tumors. Cardinal features of GBM tumor cells include their stem cell-like behaviors and highly infiltrative/migratory nature, which are main reasons why GBM is such a fatal disease. Identification of unique signaling regulators operated in GBM stem cells (GSCs) might provide important clues for developing effective therapeutics against GBMs. We are focusing on a few key molecular pathways including; 1) Polycomb-mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c-Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio- and chemo-sensitizing pathway to maximize therapeutic efficacy. By employing various aspects of stem cell biology and neuro oncology, we hope to better understand the underlying molecular mechanisms of GBM and provide potential therapeutic options.
Lee et al., Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastomas-initiating cells. (2008) Cancer Cell 13; 69-80.
Son et al., SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. (2009) Cell Stem Cell 4, 440-452.
Kim Y et al., Wnt activation is implicated in glioblastoma radioresistance. (2012) Lab Invest. 92:466-73.
Joo et al., MET signaling regulates glioblastoma stem cells. (2012) Cancer Research 72: 3828-38.