We are seeking candidates across disciplines with multiple skill levels, and as such the level of appointment will be commensurate with experience of the candidate. In some cases opportunities for a faculty appointment within the Cleveland Clinic Lerner College of Medicine may be offered, with light teaching and guest lecturing in the broader arena of drug discovery.  

In all cases the ideal candidate will be enthusiastic to learn and collaborate with scientists working in a wide variety of disease areas. They will possess excellent written and verbal communication skills, perform well in a high functioning team environment, and be an active participant in helping the center, investigators, and collaborators obtain translational funding.

If interested, please provide a cover letter describing your relevant experience, a curriculum vitae, and a short research summary of your work to stauffs2@ccf.org

Group Leader, Screening and Target Validation

Education: PhD in Molecular Pharmacology, Biochemistry or related field

Experience: 6 or more years experience post PhD in a major pharmaceutical company, biotech, or related drug discovery institute with experience in automation, chemical biology, high throughput screening, and assay development using both biochemical and cell-based approaches.

Specific Job Duties:

  • Perform biochemical and cell-based assay development and apply towards medium and high throughput screening efforts suitable for 96 and 384-well formats
  • Establish and draft robust assay protocols
  • Oversee target protein constructs, expression, purification, and characterization to be used in small molecule screening campaigns and structure-based design efforts
  • Manage and oversee activities within an active biology team across multiple projects
  • Mentor and train junior staff and biologists
  • Provide direction for compound management, including additional library acquisitions, storage and plate handling
  • Interact with chemistry counterparts, lead investigators, and be able to present latest findings and articulate new directions and strategies before project teams and institute leadership
  • Serve as project biology co-lead and facilitate direction of project teams and small molecule de-risking activities
  • Contribute to research as author or co-author on research publications
  • Participate and contribute to grant submissions with collaborators

The ideal candidate will possess excellent verbal and written communication skills, perform well in a high functioning team environment, and be an active participant in helping the center, investigators, and collaborators obtain translational funding. Experience with target identification/validation techniques highly desired and a proven ability to lead productive research teams in an iterative discovery setting. In addition, candidate will participate in the facilitation of interactions with outside collaborations and corporate partners. 



Postdoctoral Research Fellow, Medicinal Chemistry

Postdoctoral chemists will have the opportunity to learn and apply cutting-edge approaches to discover and develop small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. Fellows will be primarily tasked with the synthesis of chemical matter with a willingness to learn medicinal chemistry principles. Contributions to molecular design are highly encouraged. This position offers the unique ability to work on a variety of chemical matter targeted against different therapeutic targets, including enzymes and protein-protein complexes, and provides extensive opportunities to collaborate with CCF researchers.

Education: PhD in Synthetic Organic Chemistry, Medicinal Chemistry or related field

Specific Job Duties:

  • Synthesis of target molecules with minimal supervision
  • Apply problem-solving skills to allow efficient synthesis of challenging targets and for scale-up
  • Record, interpret, and annotate analytical data (LCMS, NMR, etc.)
  • Willingness to learn principles of medicinal chemistry, including structure-activity relationships, DMPK profiling, …
  • Interact with biologist counterparts and be able to present findings and articulate new directions before project teams
  • Contribute to research so as to merit serving as author or co-author on research publications
  • Generation of reliable and consistent results
  • Adherence to all CCF guidelines, including safety practices

If interested, please provide a cover letter describing your relevant experience, a curriculum vitae, and a short research summary of your work to stauffs2@ccf.org

 


Postdoctoral Research Fellow, Molecular and Cellular Biology

We are seeking highly motivated postdoctoral biology candidates across a range of skill-sets, they will have the opportunity to learn and apply cutting-edge approaches to discover and develop small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. Fellows will be primarily tasked with the development of biochemical and cell based assays for high throughput drug screening and validation of hit compounds, while also providing significant scope for the deeper study of compound mechanism through multiple techniques. This position offers the unique ability to work on a variety of target proteins, protein-protein complexes and extensive opportunities to collaborate with CCF researchers.

Education: PhD in Molecular Biology, Cell Biology, Biochemistry, or related field

Specific Job Duties:

  • Development and implementation of biochemical and/or cell-based assays amenable to high throughput drug screening with a variety of readout technologies
  • Generation of stable cell lines for specific targets
  • Deep understanding of ligand/receptor interactions & signal transduction, allowing for mechanistic studies using the developed small molecule chemical probes
  • Interact with chemist counterparts and be able to present findings and articulate new directions before project teams
  • Contribute to research so as to merit serving as author or co-author on research publications
  • Generation of reliable and consistent results
  • Adherence to all CCF guidelines, including safety practices

If interested, please provide a cover letter describing your relevant experience, a curriculum vitae, and a short research summary of your work to stauffs2@ccf.org


Postdoctoral Research Fellow, Structural Biology

Postdoctoral structural biologists will have the opportunity to learn and apply cutting-edge approaches to aid in the discovery and development of small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. Structural biology fellows will play a vital roll in the drug discovery process by solving protein-ligand complexes, thereby enabling structure-based design. Additionally, fellows will help with the development of biochemical assays for the purpose of small molecule drug screening and target validation. This position offers the ability to work on a variety of target proteins, protein-protein complexes and extensive opportunities to collaborate with CCF researchers.

Education: PhD in Biochemistry, Chemistry, Molecular Biology, or related field

Specific Job Duties:

  • Clone, express and purify recombinant proteins of interest
  • Solve protein-ligand structures via protein crystallography, solution-based NMR, and/or cryo-EM
  • Develop robust biochemical assays for screening campaigns using a variety of assay technologies; suitable for HTS and fragment-based screening methods
  • Interpret Structure Activity Relationships (SAR) to help advance projects
  • Generation of target models for the purpose of in silico drug development
  • Interact with chemist counterparts and be able to present findings and articulate new directions before project teams
  • Contribute to research so as to merit serving as author or co-author on research publications
  • Generation of reliable and consistent results
  • Adherence to all CCF guidelines, including safety practices

Required Experience:

  • Experience in structure determination using X-ray crystallography, protein NMR and/or cryo-EM

If interested, please provide a cover letter describing your relevant experience, a curriculum vitae, and a short research summary of your work to stauffs2@ccf.org

 


Research assistants will have the opportunity to learn and apply cutting-edge approaches to discover and develop small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. The role demands a highly goal-driven approach with the ability to achieve time-sensitive objectives in a dynamic, collaborative environment. Medicinal chemistry research assistants will play an important role in the synthesis of a diverse range of compounds designed against multiple protein targets, and opportunities for career growth are strongly encouraged.

Education: BA/BS or MS in Organic Chemistry or related fields

Specific Job Duties:

  • Routine organic synthesis experiments, under appropriate supervision as required
  • Identify, isolate and purify organic compounds
  • Thoroughly record experimental details using electronic notebook software, and annotate analytical data (LCMS, NMR, etc.), with ability to interpret data desired or desire to learn
  • Generation of reliable and consistent results
  • Adherence to all CCF guidelines, including safety practices
  • Willingness to learn principles of medicinal chemistry, including structure-activity relationships, DMPK profiling
  • Communication of research results in periodic written and oral presentations
  • Contributions to publications in peer-reviewed journals

Preferred Experience:

  • Ability to perform parallel synthesis
  • Comfort with chromatography techniques, including willingness to learn automated methodologies

Research Assistant, Biology

Research assistants will have the opportunity to learn and apply cutting-edge approaches to discover and develop small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. The role demands a highly goal-driven approach with the ability to achieve time-sensitive objectives in a dynamic, collaborative environment. Biology research assistants will play an important role in the crystallographic or solution-based structure determination of protein-drug complexes. Additionally, research assistants may be asked to run established biochemical and/or cell based assays for the purpose of both routine periodic screening, and high-throughput screening campaigns.

Opportunities for career growth are strongly encouraged.

Education: MS in Biochemistry, Biology, Chemistry or related fields, or BA/BS with laboratory experience

Specific Job Duties:

  • Assist in the expression, purification and crystallization of desired target proteins by following established protocols
  • Help to develop new protocols under appropriate supervision
  • Assist in high throughput drug screening of target proteins by following established assay protocols
  • Generation of reliable and consistent results
  • Thoroughly record experimental details and results using electronic notebook software
  • Willingness to learn to implement new theory and methodologies
  • Adherence to all CCF guidelines, including safety practices
  • Communication of research results in periodic written and oral presentations
  • Contributions to publications in peer-reviewed journals

Preferred experience in any of the following:

  • Molecular cloning and recombinant protein expression (bacterial, insect, or human expression systems)
  • Protein purification using chromatographic methods (ex. affinity or size exclusion) on purification systems (GE Healthcare or BioRad)
  • Electrophoretic methods (SDS-PAGE/agarose) and mass spec analysis of peptides (MALDI-MS)
  • Protein crystallography, protein NMR, or Cryo-EM  (highly desired, but not required)
  • Running in vitro biochemical or cell-based assays

Research assistants will have the opportunity to learn and apply cutting-edge approaches to discover and develop small molecule inhibitors across multiple disease areas, including oncology, inflammation, cardiovascular and neuroscience. The role demands a highly goal-driven approach with the ability to achieve time-sensitive objectives in a dynamic, collaborative environment. Biology research assistants will play an important role in the crystallographic or solution-based structure determination of protein-drug complexes. Additionally, research assistants may be asked to run established biochemical and/or cell based assays for the purpose of both routine periodic screening, and high-throughput screening campaigns.

Opportunities for career growth are strongly encouraged.

Education: BA/BS or MS in Biochemistry, Biology, Chemistry or related fields

Specific Job Duties:

  • Assist in the expression, purification and crystallization of desired target proteins by following established protocols
  • Help to develop new protocols under appropriate supervision
  • Assist in high throughput drug screening of target proteins by following established assay protocols
  • Generation of reliable and consistent results
  • Thoroughly record experimental details and results using electronic notebook software
  • Willingness to learn to implement new theory and methodologies
  • Adherence to all CCF guidelines, including safety practices
  • Communication of research results in periodic written and oral presentations
  • Contributions to publications in peer-reviewed journals

Preferred experience in any of the following:

  • Molecular cloning and recombinant protein expression (bacterial, insect, or human expression systems)
  • Protein purification using chromatographic methods (ex. affinity or size exclusion) on purification systems (GE Healthcare or BioRad)
  • Electrophoretic methods (SDS-PAGE/agarose) and mass spec analysis of peptides (MALDI-MS)
  • Protein crystallography, protein NMR, or Cryo-EM  (highly desired, but not required)
  • Running in vitro biochemical or cell-based assays