Postdoctoral 3

Date Contact Description
12/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.

11/01/2018 Kali Casale
casalek@ccf.org

Molecular Mechanisms and Translational Investigation of Advanced Prostate Cancer

A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic. 

Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

1)      Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression

2)      Clinical validation in patients and clinical trials utilizing innovative approaches

3)      Animal models of advanced prostate cancer for translational and therapeutic studies

4)      Identifying targets for the development of new pharmacologic therapies

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2018 Apr 1;4(4):558-562).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018 Aug 1;128(8):3333-3340).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates should hold a doctoral degree with a background in molecular biology, chemistry, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org

09/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow positions are available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.



Technical & Adminstrative

Applications for technical research positions and administrative positions at the Lerner Research Institute can be submitted on the Cleveland Clinic jobs web site.