Postdoctoral 8

Date Contact Description
06/03/2018 Zihua Gong
gongz@ccf.org
We are currently seeking ambitious, enthusiastic, and motivated Postdoctoral Fellows to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment. Current studies include DNA repair pathway choice in cancer treatment and various DNA damage proteins in replication stress. We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. Recent Ph.D. graduates or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply. Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org. The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.
05/18/2018 Dr. Hannelore Heemers
heemerh@ccf.org

We are currently seeking an ambitious, enthusiastic, and self-motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute.  Our NIH- and DOD-funded research program is focused on understanding the therapeutic potential of discrete mechanisms of androgen action in prostate cancer. Current studies include targeting contribution of coregulators to androgen action and inhibiting indirect mechanisms of androgen action. We seek candidates with strong qualifications in the following areas: molecular and cellular biology, genomics and human tissue culture techniques. Preferred candidates have a background in integrated cancer biology approaches, have previous experience with systems biology, and function well in a multidisciplinary team to ascertain the clinical applicability of bench results. Recent Ph.D. graduate or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply. A Ph.D and/or M.D. with relevant research experience is required.  Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Hannelore Heemers (heemerh@ccf.org). The Cleveland Clinic is one of the top medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes. 

05/09/2018 Kali Casale
casalek@ccf.org

Drug Discovery for Advanced Prostate Cancer

A postdoctoral fellowship position for drug discovery is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic in the Department of Cancer Biology. 

Our laboratory and translational research program is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. 

A postdoctoral fellowship is available for drug discovery against a newly credentialed molecular target against prostate cancer.  The candidate will take a leading role in the development of a compound screening assay for the identification and validation of a lead inhibitor compound against the molecular target, defining the mechanism of compound interaction with the target and optimizing the properties and potency of the lead compound.

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology and has the appropriate expertise that can be applied to drug development.  Outstanding verbal and communication skills are required.

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084), that we have shown drives poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2017 Oct 12), yet serves as a tumor vulnerability to alternative steroid ablation inhibitors (Almassi, et al. JAMA Oncol. 2017 Oct 12). 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org

 

 

 

10/25/2017 Kali Casale
casalek@ccf.org

Drug Discovery for Advanced Prostate Cancer

A postdoctoral fellowship position for drug discovery is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic in the Department of Cancer Biology. 

Our laboratory and translational research program is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. 

A postdoctoral fellowship is available for drug discovery against a newly credentialed molecular target against prostate cancer.  The candidate will take a leading role in the development of a compound screening assay for the identification and validation of a lead inhibitor compound against the molecular target, defining the mechanism of compound interaction with the target and optimizing the properties and potency of the lead compound.

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology and has the appropriate expertise that can be applied to drug development.  Outstanding verbal and communication skills are required.

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084), that we have shown drives poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2017 Oct 12), yet serves as a tumor vulnerability to alternative steroid ablation inhibitors (Almassi, et al. JAMA Oncol. 2017 Oct 12). 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org

08/18/2017 Brian Rubin, MD, PhD
rubinb2@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Department of Cancer Biology in the Lerner Research Institute.

The position involves charactizing mouse models of breast cancer and sarcoma including developmental defects caused by expression of oncogenes in the germline. A strong background working with genetically engineered mouse models is required. Salary is negotiable.

Please send your curriculum vitae, a brief letter, and the names, addresses, and telephone numbers of three references  to Dr. Brian Rubin at rubinb2@ccf.org.

07/19/2017 Zihua Gong
gongz@ccf.org

We are currently seeking an ambitious, enthusiastic, and motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment (see our publications: Genes Dev, 2693-8, 2014; Mol Cell, 667-78, 2013; Mol Cell, 438-46, 2010). Current studies include DNA repair pathway choice in cancer treatment and various DNA damage proteins in replication stress. We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models.

Application Requirements:

A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.

06/26/2017 Nima Sharifi, M.D.
sharifn@ccf.org

Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer

A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology. 

Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

1)      Metabolic and genetic changes required for androgen synthesis

2)      Clinical validation in patients and clinical trials utilizing innovative approaches

3)      Animal models of advanced prostate cancer for translational and therapeutic studies

4)      Identifying targets for the development of new pharmacologic therapies


We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   We are currently working toward defining the relationship between metabolite generation and treatment response in patients and identifying new chemical entities that are determinants of treatment response.

Previously, we discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite.  This metabolic pathway occurs in patient tumors (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33). 

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates should hold a doctoral degree with a background in molecular biology, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

sharifn@ccf.og

05/18/2017 Hannelore Heemers
heemerh@ccf.org

We are currently seeking an ambitious, enthusiastic, and self-motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute.  Our NIH- and DOD-funded research program is focused on understanding the therapeutic potential of discrete mechanisms of androgen action in prostate cancer. Current studies include targeting the contribution of coregulators to androgen action and inhibiting indirect mechanisms of androgen action.

We seek candidates with strong qualifications in the following areas: molecular and cellular biology, genomics and human tissue culture techniques. Preferred candidates have a background in integrated cancer biology approaches, have previous experience with systems biology, and function well in a multidisciplinary team to ascertain the clinical applicability of bench results. Recent Ph.D. graduates or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply.

A Ph.D. and/or M.D. with relevant research experience is required.  Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Send applications and informal inquiries to Dr. Hannelore Heemers (heemerh@ccf.org). The Cleveland Clinic is one of the top medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes. 



Technical & Adminstrative

Applications for technical research positions and administrative positions at the Lerner Research Institute can be submitted on the Cleveland Clinic jobs web site.