Jianjun Wu, PhD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Our research focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer. Innate immune system mainly relies on pattern recognition receptors (PRRs) to detect invading pathogens and to mount robust anti-microbial immune responses. However, under certain circumstances, PRRs can be self-activated under sterile condition, leading to activation of adaptive immunity and thus triggering either protective immunity or immune disorders in different contexts. The main goal of the lab is to understand the molecular mechanism of innate immune control of adaptive immunity in cancer and inflammation. We aim to: 1) Study the molecular regulation of innate immunity in tumor microenvironment (TME), with the goal of harnessing innate immunity to improve cancer immunotherapy; 2) Understand how innate immunity is initiated in inflammatory environment, and its impact on inflammation and immune disorders.
- Wu, J., Dobbs, N., Yang, K., and Yan, N. (2020). Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion. Immunity 53, 115-126 e115.
- Pokatayev, V., Yang, K., Tu, X., Dobbs, N., Wu, J., Kalb, R.G., and Yan, N. (2020). Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nat Immunol 21, 158-167.
- Wu, J., Chen, Y.J., Dobbs, N., Sakai, T., Liou, J., Miner, J.J., and Yan, N. (2019). STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med 216, 867-883.
- Wu, J., and Yan, N. (2019). STIM1 moonlights as an anchor for STING. Nat Immunol 20, 112-114.
- Warner, J.D., Irizarry-Caro, R.A., Bennion, B.G., Ai, T.L., Smith, A.M., Miner, C.A., Sakai, T., Gonugunta, V.K., Wu, J., Platt, D.J., et al. (2017). STING-associated vasculopathy develops independently of IRF3 in mice. J Exp Med 214, 3279-3292.
- Gonugunta, V.K., Sakai, T., Pokatayev, V., Yang, K., Wu, J., Dobbs, N., and Yan, N. (2017). Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response. Cell Rep 21, 3234-3242.
- Li, W., Avey, D., Fu, B., Wu, J., Ma, S., Liu, X., and Zhu, F. (2016). Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses. J Virol 90, 5329-5342.
- Wu, J., Li, W., Shao, Y., Avey, D., Fu, B., Gillen, J., Hand, T., Ma, S., Liu, X., Miley, W., et al. (2015). Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein. Cell Host Microbe 18, 333-344.
- Wu, J., Avey, D., Li, W., Gillen, J., Fu, B., Miley, W., Whitby, D., and Zhu, F. (2015). ORF33 and ORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required for Optimal Production of Infectious Progeny Viruses. J Virol 90, 1741-1756.
- Gillen, J., Li, W., Liang, Q., Avey, D., Wu, J., Wu, F., Myoung, J., and Zhu, F. (2015). A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses. J Virol 89, 4918-4931.
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