Researchers Discover Young-Onset Colorectal Cancer Mortality Hot and Cold Spots
Dr. Schmit and colleagues identified geographic hot and cold spots of young-onset colorectal cancer mortality in the United States in order to highlight regions for further investigation and future preventive interventions.
Exploring a Blood-Based Biomarker of Inflammation for Alzheimer’s Disease
Dr. Bekris’ team found that patterns of sTREM2-related inflammatory activity were specific to Alzheimer’s disease stages.
GMI Postdoc Wins the 2022 Arthur F.W. Hughes Award for Embryology and Developmental Biology
Dr. Sarn was recognized for his significant contributions to the fields of developmental biology and embryology during their graduate program at Case Western Reserve University.
Expansion of Telegenetic Services During COVID-19 Pandemic
To help facilitate social distancing and protect the health of patients, providers and their families during the COVID-19 pandemic, the Center for Personalized Genetic Healthcare rapidly expanded its telegenetics program.
New Research Collaborative Aims at Closing Minority Health Disparities
With a Cleveland Clinic research co-laboratories award, Drs. Schmit and Mata will establish the Cleveland Clinic Latino Epidemiology (CCLE) Cohort to help close the gap in research participation and health disparities for the Latino population.
Characterizing Dermatologic Findings in PTEN Hamartoma Tumor Syndrome
Dr. Eng and colleagues conducted a multi-center analysis of skin findings in patients with PTEN hamartoma tumor syndrome.
Metabolites May Influence Cancer Versus Autism Risk in PTEN Hamartoma Tumor Syndrome
Dr. Eng’s team found that distinct metabolite profiles may be associated with either cancer or autism spectrum disorder and/or developmental delay in individuals with PTEN hamartoma tumor syndrome.
Prediction Model Aids in the Early Diagnosis of Dravet Syndrome
Dr. Lal and colleagues have developed a statistical model that integrates genetic and clinical data to calculate the probability of developing Dravet syndrome.
Increasing Access to Pharmacogenomics Services via a Clinical Chatbot
With a Caregiver Catalyst Grant, Dr. Hockings and colleagues will develop a chatbot that will educate patients about pharmacogenomics testing and help them make an informed decision about getting tested.
Investigating Age Differences in COVID-19 Immune Response
Dr. Cheng’s team identified several differences in immune and inflammatory responses that may help explain the elevated risk for severe illness and death observed in older COVID-19 patients.
Advancing Breast Cancer Prevention Strategies
With a grant from the American Cancer Society, Dr. Karaayvaz’s team will investigate the molecular connections linking BRCA2 to breast cancer development with the goal of developing innovative strategies for breast cancer risk assessment and prevention.
Harnessing Endophenotypes for Alzheimer’s Disease Drug Repurposing
Dr. Cheng’s team developed an endophenotype-based drug repurposing methodology that identified the FDA-approved drug sildenafil as a candidate for the prevention and treatment of Alzheimer’s disease.
Investigating the Influence of Genetic Ancestry on Colorectal Cancer Outcomes
Dr. Schmit’s team will study the role of genetic ancestry in shaping immune-related determinants of colorectal cancer outcomes.
Establishing the Cleveland Clinic Breast Cancer Center of Excellence
Led by Drs. Keri and Eng, the center will support a multi-investigator research team focused on discerning the role of the tumor microenvironment in breast cancer progression.
GMI Researchers Win 2021 Lerner Research Institute Awards for Excellence
Drs. Eng and Sarn were recognized for their outstanding achievements.
NIH Supplement Award for Alzheimer’s Disease Drug Repurposing
With this award, Dr. Cheng’s team will develop artificial intelligence and machine learning tools capable of identifying novel endophenotypes and actionable targets for drug repurposing in Alzheimer’s disease.
Developing Artificial Intelligence Tools for Alzheimer’s Disease Drug Discovery
With a new $4 million grant, Drs. Cheng, Bekris and Leverenz will develop and utilize artificial intelligence tools to identify novel drug targets and repurposable drugs for Alzheimer’s disease.
National Institute on Aging Awards $15.4 Million to Continue Support for Cleveland Alzheimer’s Disease Research Center
The multi-institution collaboration, which includes Dr. Bekris’ team, aims to accelerate research for Alzheimer’s disease and related dementias.
Artificial Intelligence Predicts Cancer Therapy-Related Cardiac Risk
A research team led by Drs. Cheng and Collier developed an artificial intelligence methodology to help identify cancer patients at risk for cancer therapy-related cardiac dysfunction.
Investigating Sex Differences in COVID-19 Immune Response
Utilizing large-scale patient data and samples from the Cleveland Clinic COVID-19 registry, Dr. Cheng’s team identified clinical characteristics and immune-related mechanisms associated with sex differences in COVID-19 outcomes.
Predicting Cognitive Performance in People with HIV
Dr. Kallianpur’s team found that higher levels of the iron-delivery proteins heavy-chain ferritin and transferrin predict better cognitive outcomes in people with HIV, independent of factors like inflammation, over an extended period of follow-up.
Characterizing the Genetic Architecture of Parkinson’s Disease in Latinos
To address the lack of diversity in Parkinson’s disease genetic research, Dr. Mata and colleagues conducted the first ever genome-wide association study of Latino Parkinson’s disease patients from South America.
GMI Researchers Receive Awards Promoting Diversity in Science
Dr. Cheng and Ms. Castrillon Lal received the Gilliam Fellowship for Advanced Study, and Dr. Smith received the MOSAIC Postdoctoral Career Transition Award to Promote Diversity.
Study Establishes Maternal Genetics as Modulator of Autism Risk
A preclinical study led by Dr. Eng indicates that maternal genetics alone may contribute to increased risk for autism spectrum disorder in offspring.