GMI Postdocs Receive National Hemophilia Foundation Fellowship Awards
06/15/2021

With their awards, Drs. Srivastava and Zhang will study the blood-clotting protein factor VIII.

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Network Medicine Links COVID-19 and Alzheimer’s Disease-like Cognitive Impairment
06/11/2021

Utilizing network medicine methodologies, a research team led by Dr. Cheng linked COVID-19 to neuroinflammation and brain microvascular injury in Alzheimer’s disease-like cognitive impairment.

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Breast Microbiome-Immune Interactions May Influence Breast Cancer
05/18/2021

Dr. Eng and colleagues found that the breast microbiome may modulate local immune responses that lead to breast cancer.

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Study Links Gene Variant with Alzheimer’s Disease Resilience
04/27/2021

Dr. Bekris’ team has found that Alzheimer’s disease resilience may be modulated by interactions between a TNFRSF1B gene variant and the protein sTNFR2.

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Precision Medicine in Migraine Treatment
04/26/2021

With their Co-Laboratories Award, Drs. Mata and Ahmed will team up to develop a way to predict patient response to FDA-approved treatments for migraine prevention.

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Researchers to Study Genetics of Focal Cortical Dysplasia with New NIH Grant
04/21/2021

Dr. Lal’s team will perform the most comprehensive genetic analysis of focal cortical dysplasia (FCD) to confirm proposed FCD-associated genes and identify novel FCD causal genes and variants.

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Cancer Genetics Researchers Receive VeloSano Awards
04/20/2021

These awards provide Drs. Eng, Lal and Lesmana with seed funding for their highly innovative and potentially impactful cancer research projects.

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NIH Grant to Study Iron Dysregulation and Neuropsychiatric Disorders in People with HIV
04/13/2021

Dr. Kallianpur’s team will investigate the role of iron in depression and cognitive impairment in people with HIV.

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Colorectal Cancer Relapse Predicted by Immune Cell Infiltration
04/06/2021

Dr. Schmit and colleagues found that immune cell infiltration of colorectal tumors can predict disease relapse in patients who undergo surgery with curative intent.

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Aging Mind Foundation Grant to Investigate Inflammation Biomarker in Alzheimer’s Disease
03/30/2021

Dr. Bekris’s team will study the protein TREM2 as a biomarker of inflammation in pre-symptomatic and early symptomatic stages of Alzheimer’s disease.

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NIH Awards $4.6M to Study Human Cytomegalovirus Latency and Reactivation
03/30/2021

Dr. O’Connor’s team will investigate the underlying mechanisms by which human cytomegalovirus manipulates host cells to regulate viral latency and reactivation.

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New NIH Grant to Study Antiviral Factor in Human Cytomegalovirus
03/19/2021

With this funding, Drs. O’Connor and Longworth will investigate how host cells attempt to subvert human cytomegalovirus replication.

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Uncovering the Link between the Gut and Autoimmunity in Patients with PTEN Hamartoma Tumor Syndrome
03/03/2021

A pilot study led by Dr. Eng suggests that the gut microbiome may contribute to the development of autoimmune diseases and immune dysregulation in patients with PTEN hamartoma tumor syndrome.

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GMI Postdoc Receives National Cancer Institute Fellowship Award
03/02/2021

With this award, Dr. Fink will investigate the cause of abnormal DNA methylation in colorectal cancer development.

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Microbiome Reveals Clues to Male Infertility
02/24/2021

In collaboration with Dr. Eng, Dr. Lundy and colleagues compared the microbiomes of infertile and fertile men and identified several bacterial and metabolic pathway differences that may help diagnose and treat male infertility.

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Researchers Develop Interactive Platform to Identify Druggable Cancer Mutations
02/08/2021

Dr. Cheng and team developed a personalized genomic medicine platform to identify clinically actionable mutations and accelerate the development of cancer precision medicine protocols.

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W.M. Keck Foundation Grant to Study Potential Link Between Bacteria and Cancer
02/04/2021

Dr. Ting and collaborators from Fred Hutchinson Cancer Research Center will investigate if bacterial enzymes directly modify the human genome to promote cancer.

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Study Shows Machine Learning’s Potential to Predict Cancer Therapy-Related Cardiac Risk
01/06/2021

An interdisciplinary team led by Drs. Cheng and Collier developed machine learning models that predict with promising accuracy the risk of cardiac dysfunction in cancer survivors and may be generalizable to clinical practice.

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Cleveland Clinic Researchers Use “Big Data” Approach to Identify Melatonin as Possible COVID-19 Treatment
11/09/2020

Dr. Cheng and colleagues developed a network medicine strategy to predict disease manifestations associated with COVID-19 and find existing drugs with the potential to be effective COVID-19 treatments.

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Not All Mutations are Bad: Researchers Identify Differences between Benign and Pathogenic Variants
10/26/2020

Dr. Lal’s team conducted the first big data characterization of missense variants from 1,300 disease-associated genes to identify features associated with pathogenic and benign variants.

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GMI Graduate Students Win 2020 Lerner Research Institute Awards for Excellence
10/05/2020

Sara Akhavanfard, MD, PhD, and Abigail Dooley were recognized for their outstanding scientific achievements.

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GMI Fellow Wins Crile Research Fellowship Award
10/05/2020

With this award, Takae Brewer, MD, aims to provide further insight into the genomics of breast cancer development, invasion and metastasis in the context of PTEN hamartoma tumor syndrome.

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New Grant to Investigate Genomic Alterations Influencing PTEN Hamartoma Tumor Syndrome
09/11/2020

Dr. Eng’s team will sequence the genomes of patients with PTEN hamartoma tumor syndrome to determine if and how changes in non-coding regions of the genome affect clinical outcomes.

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NIH Supplement Award for COVID-19 Drug Repurposing
09/02/2020

Dr. Cheng and his team aim to identify repurposable drugs and combination regimens to treat COVID-19 in older adults

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