NIH Supplement Award for Alzheimer’s Disease Drug Repurposing
09/15/2021

With this award, Dr. Cheng’s team will develop artificial intelligence and machine learning tools capable of identifying novel endophenotypes and actionable targets for drug repurposing in Alzheimer’s disease.

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Developing Artificial Intelligence Tools for Alzheimer’s Disease Drug Discovery
08/30/2021

With a new $4 million grant, Drs. Cheng, Bekris and Leverenz will develop and utilize artificial intelligence tools to identify novel drug targets and repurposable drugs for Alzheimer’s disease.

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National Institute on Aging Awards $15.4 Million to Continue Support for Cleveland Alzheimer’s Disease Research Center
08/27/2021

The multi-institution collaboration, which includes Dr. Bekris’ team, aims to accelerate research for Alzheimer’s disease and related dementias.

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Artificial Intelligence Predicts Cancer Therapy-Related Cardiac Risk
08/05/2021

A research team led by Drs. Cheng and Collier developed an artificial intelligence methodology to help identify cancer patients at risk for cancer therapy-related cardiac dysfunction.

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Investigating Sex Differences in COVID-19 Immune Response
08/04/2021

Utilizing large-scale patient data and samples from the Cleveland Clinic COVID-19 registry, Dr. Cheng’s team identified clinical characteristics and immune-related mechanisms associated with sex differences in COVID-19 outcomes.

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Predicting Cognitive Performance in People with HIV
08/02/2021

Dr. Kallianpur’s team found that higher levels of the iron-delivery proteins heavy-chain ferritin and transferrin predict better cognitive outcomes in people with HIV, independent of factors like inflammation, over an extended period of follow-up.

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Characterizing the Genetic Architecture of Parkinson’s Disease in Latinos
07/27/2021

To address the lack of diversity in Parkinson’s disease genetic research, Dr. Mata and colleagues conducted the first ever genome-wide association study of Latino Parkinson’s disease patients from South America.

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GMI Researchers Receive Awards Promoting Diversity in Science
07/22/2021

Dr. Cheng and Ms. Castrillon Lal received the Gilliam Fellowship for Advanced Study, and Dr. Smith received the MOSAIC Postdoctoral Career Transition Award to Promote Diversity.

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Study Establishes Maternal Genetics as Modulator of Autism Risk
07/20/2021

A preclinical study led by Dr. Eng indicates that maternal genetics alone may contribute to increased risk for autism spectrum disorder in offspring.

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Artificial Intelligence Methodology for Alzheimer’s Disease Drug Repurposing
07/20/2021

Dr. Cheng’s team developed an artificial intelligence methodology to uncover molecular targets involved in neuroinflammation and identify candidate therapeutics for Alzheimer’s disease.

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Predicting Efficacy and Safety of COVID-19 Vaccines in Cancer Patients
07/08/2021

Dr. Eng has received a Caregiver Catalyst Grant to assess the efficacy and safety of the current COVID-19 mRNA vaccines in individuals with cancer or a high genetic susceptibility to cancer due to heritable PTEN mutations.

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GMI Postdocs Receive National Hemophilia Foundation Fellowship Awards
06/15/2021

With their awards, Drs. Srivastava and Zhang will study the blood-clotting protein factor VIII.

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Network Medicine Links COVID-19 and Alzheimer’s Disease-like Cognitive Impairment
06/11/2021

Utilizing network medicine methodologies, a research team led by Dr. Cheng linked COVID-19 to neuroinflammation and brain microvascular injury in Alzheimer’s disease-like cognitive impairment.

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Breast Microbiome-Immune Interactions May Influence Breast Cancer
05/18/2021

Dr. Eng and colleagues found that the breast microbiome may modulate local immune responses that lead to breast cancer.

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Study Links Gene Variant with Alzheimer’s Disease Resilience
04/27/2021

Dr. Bekris’ team has found that Alzheimer’s disease resilience may be modulated by interactions between a TNFRSF1B gene variant and the protein sTNFR2.

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Precision Medicine in Migraine Treatment
04/26/2021

With their Co-Laboratories Award, Drs. Mata and Ahmed will team up to develop a way to predict patient response to FDA-approved treatments for migraine prevention.

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Researchers to Study Genetics of Focal Cortical Dysplasia with New NIH Grant
04/21/2021

Dr. Lal’s team will perform the most comprehensive genetic analysis of focal cortical dysplasia (FCD) to confirm proposed FCD-associated genes and identify novel FCD causal genes and variants.

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Cancer Genetics Researchers Receive VeloSano Awards
04/20/2021

These awards provide Drs. Eng, Lal and Lesmana with seed funding for their highly innovative and potentially impactful cancer research projects.

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NIH Grant to Study Iron Dysregulation and Neuropsychiatric Disorders in People with HIV
04/13/2021

Dr. Kallianpur’s team will investigate the role of iron in depression and cognitive impairment in people with HIV.

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Colorectal Cancer Relapse Predicted by Immune Cell Infiltration
04/06/2021

Dr. Schmit and colleagues found that immune cell infiltration of colorectal tumors can predict disease relapse in patients who undergo surgery with curative intent.

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Aging Mind Foundation Grant to Investigate Inflammation Biomarker in Alzheimer’s Disease
03/30/2021

Dr. Bekris’s team will study the protein TREM2 as a biomarker of inflammation in pre-symptomatic and early symptomatic stages of Alzheimer’s disease.

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NIH Awards $4.6M to Study Human Cytomegalovirus Latency and Reactivation
03/30/2021

Dr. O’Connor’s team will investigate the underlying mechanisms by which human cytomegalovirus manipulates host cells to regulate viral latency and reactivation.

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New NIH Grant to Study Antiviral Factor in Human Cytomegalovirus
03/19/2021

With this funding, Drs. O’Connor and Longworth will investigate how host cells attempt to subvert human cytomegalovirus replication.

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Uncovering the Link between the Gut and Autoimmunity in Patients with PTEN Hamartoma Tumor Syndrome
03/03/2021

A pilot study led by Dr. Eng suggests that the gut microbiome may contribute to the development of autoimmune diseases and immune dysregulation in patients with PTEN hamartoma tumor syndrome.

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