NIH Supplement Award for Alzheimer’s Disease Drug Repurposing
With this award, Dr. Cheng’s team will develop artificial intelligence and machine learning tools capable of identifying novel endophenotypes and actionable targets for drug repurposing in Alzheimer’s disease.
Developing Artificial Intelligence Tools for Alzheimer’s Disease Drug Discovery
With a new $4 million grant, Drs. Cheng, Bekris and Leverenz will develop and utilize artificial intelligence tools to identify novel drug targets and repurposable drugs for Alzheimer’s disease.
National Institute on Aging Awards $15.4 Million to Continue Support for Cleveland Alzheimer’s Disease Research Center
The multi-institution collaboration, which includes Dr. Bekris’ team, aims to accelerate research for Alzheimer’s disease and related dementias.
Artificial Intelligence Predicts Cancer Therapy-Related Cardiac Risk
A research team led by Drs. Cheng and Collier developed an artificial intelligence methodology to help identify cancer patients at risk for cancer therapy-related cardiac dysfunction.
Investigating Sex Differences in COVID-19 Immune Response
Utilizing large-scale patient data and samples from the Cleveland Clinic COVID-19 registry, Dr. Cheng’s team identified clinical characteristics and immune-related mechanisms associated with sex differences in COVID-19 outcomes.
Predicting Cognitive Performance in People with HIV
Dr. Kallianpur’s team found that higher levels of the iron-delivery proteins heavy-chain ferritin and transferrin predict better cognitive outcomes in people with HIV, independent of factors like inflammation, over an extended period of follow-up.
Characterizing the Genetic Architecture of Parkinson’s Disease in Latinos
To address the lack of diversity in Parkinson’s disease genetic research, Dr. Mata and colleagues conducted the first ever genome-wide association study of Latino Parkinson’s disease patients from South America.
GMI Researchers Receive Awards Promoting Diversity in Science
Dr. Cheng and Ms. Castrillon Lal received the Gilliam Fellowship for Advanced Study, and Dr. Smith received the MOSAIC Postdoctoral Career Transition Award to Promote Diversity.
Study Establishes Maternal Genetics as Modulator of Autism Risk
A preclinical study led by Dr. Eng indicates that maternal genetics alone may contribute to increased risk for autism spectrum disorder in offspring.
Artificial Intelligence Methodology for Alzheimer’s Disease Drug Repurposing
Dr. Cheng’s team developed an artificial intelligence methodology to uncover molecular targets involved in neuroinflammation and identify candidate therapeutics for Alzheimer’s disease.
Predicting Efficacy and Safety of COVID-19 Vaccines in Cancer Patients
Dr. Eng has received a Caregiver Catalyst Grant to assess the efficacy and safety of the current COVID-19 mRNA vaccines in individuals with cancer or a high genetic susceptibility to cancer due to heritable PTEN mutations.
GMI Postdocs Receive National Hemophilia Foundation Fellowship Awards
With their awards, Drs. Srivastava and Zhang will study the blood-clotting protein factor VIII.
Network Medicine Links COVID-19 and Alzheimer’s Disease-like Cognitive Impairment
Utilizing network medicine methodologies, a research team led by Dr. Cheng linked COVID-19 to neuroinflammation and brain microvascular injury in Alzheimer’s disease-like cognitive impairment.
Breast Microbiome-Immune Interactions May Influence Breast Cancer
Dr. Eng and colleagues found that the breast microbiome may modulate local immune responses that lead to breast cancer.
Study Links Gene Variant with Alzheimer’s Disease Resilience
Dr. Bekris’ team has found that Alzheimer’s disease resilience may be modulated by interactions between a TNFRSF1B gene variant and the protein sTNFR2.
Precision Medicine in Migraine Treatment
With their Co-Laboratories Award, Drs. Mata and Ahmed will team up to develop a way to predict patient response to FDA-approved treatments for migraine prevention.
Researchers to Study Genetics of Focal Cortical Dysplasia with New NIH Grant
Dr. Lal’s team will perform the most comprehensive genetic analysis of focal cortical dysplasia (FCD) to confirm proposed FCD-associated genes and identify novel FCD causal genes and variants.
Cancer Genetics Researchers Receive VeloSano Awards
These awards provide Drs. Eng, Lal and Lesmana with seed funding for their highly innovative and potentially impactful cancer research projects.
NIH Grant to Study Iron Dysregulation and Neuropsychiatric Disorders in People with HIV
Dr. Kallianpur’s team will investigate the role of iron in depression and cognitive impairment in people with HIV.
Colorectal Cancer Relapse Predicted by Immune Cell Infiltration
Dr. Schmit and colleagues found that immune cell infiltration of colorectal tumors can predict disease relapse in patients who undergo surgery with curative intent.
Aging Mind Foundation Grant to Investigate Inflammation Biomarker in Alzheimer’s Disease
Dr. Bekris’s team will study the protein TREM2 as a biomarker of inflammation in pre-symptomatic and early symptomatic stages of Alzheimer’s disease.
NIH Awards $4.6M to Study Human Cytomegalovirus Latency and Reactivation
Dr. O’Connor’s team will investigate the underlying mechanisms by which human cytomegalovirus manipulates host cells to regulate viral latency and reactivation.
New NIH Grant to Study Antiviral Factor in Human Cytomegalovirus
With this funding, Drs. O’Connor and Longworth will investigate how host cells attempt to subvert human cytomegalovirus replication.
Uncovering the Link between the Gut and Autoimmunity in Patients with PTEN Hamartoma Tumor Syndrome
A pilot study led by Dr. Eng suggests that the gut microbiome may contribute to the development of autoimmune diseases and immune dysregulation in patients with PTEN hamartoma tumor syndrome.