GMI Postdocs Receive National Hemophilia Foundation Fellowship Awards
With their awards, Drs. Srivastava and Zhang will study the blood-clotting protein factor VIII.
Network Medicine Links COVID-19 and Alzheimer’s Disease-like Cognitive Impairment
Utilizing network medicine methodologies, a research team led by Dr. Cheng linked COVID-19 to neuroinflammation and brain microvascular injury in Alzheimer’s disease-like cognitive impairment.
Breast Microbiome-Immune Interactions May Influence Breast Cancer
Dr. Eng and colleagues found that the breast microbiome may modulate local immune responses that lead to breast cancer.
Study Links Gene Variant with Alzheimer’s Disease Resilience
Dr. Bekris’ team has found that Alzheimer’s disease resilience may be modulated by interactions between a TNFRSF1B gene variant and the protein sTNFR2.
Precision Medicine in Migraine Treatment
With their Co-Laboratories Award, Drs. Mata and Ahmed will team up to develop a way to predict patient response to FDA-approved treatments for migraine prevention.
Researchers to Study Genetics of Focal Cortical Dysplasia with New NIH Grant
Dr. Lal’s team will perform the most comprehensive genetic analysis of focal cortical dysplasia (FCD) to confirm proposed FCD-associated genes and identify novel FCD causal genes and variants.
Cancer Genetics Researchers Receive VeloSano Awards
These awards provide Drs. Eng, Lal and Lesmana with seed funding for their highly innovative and potentially impactful cancer research projects.
NIH Grant to Study Iron Dysregulation and Neuropsychiatric Disorders in People with HIV
Dr. Kallianpur’s team will investigate the role of iron in depression and cognitive impairment in people with HIV.
Colorectal Cancer Relapse Predicted by Immune Cell Infiltration
Dr. Schmit and colleagues found that immune cell infiltration of colorectal tumors can predict disease relapse in patients who undergo surgery with curative intent.
Aging Mind Foundation Grant to Investigate Inflammation Biomarker in Alzheimer’s Disease
Dr. Bekris’s team will study the protein TREM2 as a biomarker of inflammation in pre-symptomatic and early symptomatic stages of Alzheimer’s disease.
NIH Awards $4.6M to Study Human Cytomegalovirus Latency and Reactivation
Dr. O’Connor’s team will investigate the underlying mechanisms by which human cytomegalovirus manipulates host cells to regulate viral latency and reactivation.
New NIH Grant to Study Antiviral Factor in Human Cytomegalovirus
With this funding, Drs. O’Connor and Longworth will investigate how host cells attempt to subvert human cytomegalovirus replication.
Uncovering the Link between the Gut and Autoimmunity in Patients with PTEN Hamartoma Tumor Syndrome
A pilot study led by Dr. Eng suggests that the gut microbiome may contribute to the development of autoimmune diseases and immune dysregulation in patients with PTEN hamartoma tumor syndrome.
GMI Postdoc Receives National Cancer Institute Fellowship Award
With this award, Dr. Fink will investigate the cause of abnormal DNA methylation in colorectal cancer development.
Microbiome Reveals Clues to Male Infertility
In collaboration with Dr. Eng, Dr. Lundy and colleagues compared the microbiomes of infertile and fertile men and identified several bacterial and metabolic pathway differences that may help diagnose and treat male infertility.
Researchers Develop Interactive Platform to Identify Druggable Cancer Mutations
Dr. Cheng and team developed a personalized genomic medicine platform to identify clinically actionable mutations and accelerate the development of cancer precision medicine protocols.
W.M. Keck Foundation Grant to Study Potential Link Between Bacteria and Cancer
Dr. Ting and collaborators from Fred Hutchinson Cancer Research Center will investigate if bacterial enzymes directly modify the human genome to promote cancer.
Study Shows Machine Learning’s Potential to Predict Cancer Therapy-Related Cardiac Risk
An interdisciplinary team led by Drs. Cheng and Collier developed machine learning models that predict with promising accuracy the risk of cardiac dysfunction in cancer survivors and may be generalizable to clinical practice.
Cleveland Clinic Researchers Use “Big Data” Approach to Identify Melatonin as Possible COVID-19 Treatment
Dr. Cheng and colleagues developed a network medicine strategy to predict disease manifestations associated with COVID-19 and find existing drugs with the potential to be effective COVID-19 treatments.
Not All Mutations are Bad: Researchers Identify Differences between Benign and Pathogenic Variants
Dr. Lal’s team conducted the first big data characterization of missense variants from 1,300 disease-associated genes to identify features associated with pathogenic and benign variants.
GMI Graduate Students Win 2020 Lerner Research Institute Awards for Excellence
Sara Akhavanfard, MD, PhD, and Abigail Dooley were recognized for their outstanding scientific achievements.
GMI Fellow Wins Crile Research Fellowship Award
With this award, Takae Brewer, MD, aims to provide further insight into the genomics of breast cancer development, invasion and metastasis in the context of PTEN hamartoma tumor syndrome.
New Grant to Investigate Genomic Alterations Influencing PTEN Hamartoma Tumor Syndrome
Dr. Eng’s team will sequence the genomes of patients with PTEN hamartoma tumor syndrome to determine if and how changes in non-coding regions of the genome affect clinical outcomes.
NIH Supplement Award for COVID-19 Drug Repurposing
Dr. Cheng and his team aim to identify repurposable drugs and combination regimens to treat COVID-19 in older adults