The laboratory studies the mechanisms through which antibodies alter lymphocyte responses at the level of endothelial cells, platelets and leukocytes. The mechanisms have relevance to vascular pathology.
The laboratory investigates the molecular and cellular biology of chronic kidney disease.
The laboratory focuses on the translational investigation of airway inflammation and oxidative stress in asthma.
The laboratory investigates gut microbiota, targeting alterations in metabolic byproducts and centering on clinical situations in which gut dysbiosis occurs.
The laboratory focuses on the management of patients waiting for liver transplantation and during the post-transplant period.
de la Motte Lab
The laboratory investigates innate mechanisms of intestinal protection that lead to disease when dysregulated.
The laboratory investigates the role of nitric oxide (and other markers in exhaled breath) in lung physiology and in the pathophysiology of lung diseases like pulmonary hypertension and asthma.
The laboratory studies the mechanisms that initiate and perpetuate lung inflammation and remodeling and ultimately lead to lung diseases such as asthma and pulmonary vascular disease.
The laboratory investigates the role of innate immune mechanisms and CD8+ T cells in contact hypersensitivity, as well as the role of inflammatory/signaling proteins in allograft inflammation and rejection.
The laboratory studies the pathogenesis of inflammatory bowel disease, investigating immune events occurring in the bowel of Crohn’s disease and ulcerative colitis patients.
The laboratory investigates how maturation of specific hemeproteins maybe adversely affected in cardiopulmonary diseases and inflammatory myopathies.
The laboratory investigates molecular mechanisms of B cell activation that regulate humoral immunity and pathogenesis of B cell-mediated diseases.
The laboratory studies molecular events that control the expression of inducible genes during the initiation and resolution of inflammation.
The laboratory studies the roles of the actin cytoskeleton and myosin motors in disassembly and reformation of tight and adherens junctions and wound healing in the intestinal epithelium.
The laboratory focuses on the effects of sex hormones on the immune system during initiation/progression of lupus-like disease and the specific role played by type I interferons.
The laboratory explores the biomimetic microphysiological system to uncover fundamental mechanisms of host-microbiome crosstalk in health and disease.
The laboratory studies complement activation and regulation in a wide range of disease states including multiple sclerosis, myasthenia gravis and systemic lupus erythematosus, with the goal of developing novel therapies.
The laboratory investigates the signaling mechanisms in innate and adaptive immunity.
The laboratory investigates how changes to DNA organization within the nucleus of a cell impact development and disease.
The laboratory investigates mechanisms that lead to lung transplant complications and the role they play in managing risk and mortality post-transplant.
The laboratory investigates immune response control and how alterations in these responses contribute to the development of Crohn’s disease.
The laboratory studies the role of gut microbes in chronic inflammatory diseases. Our focus is on identifying disease-causing changes in microbial behavior across the gut microbial community.
The laboratory studies how chronic alcohol consumption contributes to diseases such as liver disease and diabetes.
The laboratory is focused on the pathogenesis idiopathic pulmonary fibrosis, a fatal and currently untreatable disorder.
The laboratory focuses on mitochondrial diseases related to mutations in either the nuclear or mitochondrial genome.
The laboratory studies how inflammation and oxidative stress contribute to atherosclerosis and thrombosis via lipid peroxidation and formation of bioactive lipids.
The laboratory investigates the impact of viral infection and environmental factors on airway epithelial barrier and inflammation with relevance to respiratory viral infections and asthma.
The laboratory investigates novel mechanisms of intestinal fibrogenesis, the prediction of fibrostenosing disease courses and innovative ways to treat patients with inflammatory bowel disease who have established strictures.
The laboratory studies how telomeres differ from DNA breaks, and how the cell division kinase Pef1 regulates autophagy and cell lifespan using the yeast Schizosaccharomyces pombe.
The laboratory investigates the pathogenesis of human liver diseases including biliary atresia and nonalcoholic steatohepatitis.
The laboratory studies mechanosensitive receptors in the treatment of respiratory distress syndrome.
The laboratory studies progressive kidney disease mechanisms to define the clinical, cellular and genetic bases of kidney disease to identify new therapies and diagnostic tests.
The laboratory investigates how mammals respond to virus infection, both at the cellular level and organism level.
The laboratory studies host and environmental factors that impact inflammation and wound repair, which influence the pathogenesis of diseases including inflammatory bowel disease.
The laboratory studies nitric oxide biosynthesis in mammals involved in cell function and disease.
The laboratory focuses on developing vaccines capable of providing primary immunoprevention of adult-onset cancers including breast cancer, ovarian cancer, and endometrial cancer.
The laboratory investigates the functions of graft-reactive memory CD4 T cells in organ transplant, with the ultimate goal to develop combinatorial therapies for sensitized transplant recipients.