Edward J. Mascha,  PhD

Edward J. Mascha, PhD

Associate Staff

(Joint appointment with Department of Outcomes Research in the Anesthesiology Institute)

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: P77-007
Email: maschae@ccf.org
Phone: (216) 445-7805
Fax: (216) 444-6135


Research Description

Dr. Mascha has led Biostatistical collaboration and research methodology for the Cleveland Clinic’s Anesthesiology Institute since 2005 and has over 25 years of experience as collaborative Biostatistician in perioperative medicine and various disease areas. His interests include design and monitoring of clinical trials, causal inference, inference on multiple correlated outcomes, mediation analysis, and complex equivalence and noninferiority designs. His current research involves expanding methods for analyzing composite endpoints containing binary, ordinal or mixed data types (see binary event design software), estimating heterogeneity of individual treatment effects using potential outcomes and mediation analysis for multiple mediators & outcomes. His journal publications are listed here.


Lecturer: Anesthesiology Institute’s Fundamentals of Clinical Research series, Comprehensive Anesthesiology Review and Resident Education classes; Introduction to Clinical Trials (CMED450)

Statistical Editor: Anesthesia and Analgesia

Statistical Reviewer: Anesthesia and Analgesia, Anesthesiology, Vascular Surgery.

Mascha EJ.  Alpha, Beta, Meta: Guidelines for assessing Power and Type I error in meta-analyses.  (Editorial) Anesth Analg 2015, 121(6):1430-3.

Mascha EJ, Mazo V. Predicting in-hospital postoperative mortality for the practitioner: Beyond the numbers. (Editorial) Anesthesiology 2016, 124(3):523-5.

Mascha EJ, Yang D, Weiss S, Sessler DI: Intraoperative Mean Arterial Pressure Variability and 30-day Mortality in Patients Having Noncardiac Surgery. Anesthesiology 2015; 123: 79-91.

Mascha EJ, Dalton J, Kurz A, Saager L. Understanding the mechanism: Mediation analysis in randomized and non-randomized studies. Anesth Analg 2013, 117: 980-94.

Mascha EJ, Turan A. Joint hypothesis testing and gatekeeping procedures for studies with multiple outcomes. Anesth Analg 2012, 114(6):1304-1317.

Mascha EJ, Sessler DI.  Design and Analysis of Binary-Event Composite Endpoint Studies: Guidelines for Anesthesia Research. Anesthesia and Analgesia 2011, 112 (6):1461-71.

Mascha EJ, Sessler DI.  Statistical grand rounds: Equivalence and noninferiority testing for regression models and repeated measures designs. Anesth Analg 2011, 112: 678–687.

Mascha EJ.  Equivalence and Noninferiority Testing in Anesthesiology Research.  Anesthesiology 2010, 113: 779-781.

Mascha EJ, Imrey PB: Factors affecting power of tests for multiple binary outcomes. Statistics in Medicine 2010; 29: 2890-2904.

Mascha E, Albert J. Estimating treatment effect heterogeneity for binary outcomes via Dirichlet multinomial constraints. Biometrical Journal 2007; 49 (3): 378-393.

Mascha E, Albert J.  Statistical properties of bound estimators on treatment effect heterogeneity for binary outcomes. Journal of Modern Applied Statistical Methods 2006; 5(1), 181-193.

Dalton JE, Glance LG, Mascha EJ, Ehrlinger J, Chamoun N, Sessler DI (2013). Impact of present-on-admission indicators on risk-adjusted hospital mortality measurement. Anesthesiology 118, 1298-1306.

Abdelmalak BB, Bonilla A, Mascha EJ, Maheshwari A, Tang WH, You J, Ramachandran M, Kirkova Y, Clair D, Walsh RM, Kurz A, Sessler DI (2013). Dexamethasone, light anaesthesia, and tight glucose control (DeLiT) randomized controlled trial. Br J Anaesth 111, 209-221.



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