HOW TO USE DESIGNROC.for ************************ DESIGNROC.for is an interactive FORTRAN program for estimating sample size and/ or power in ROC studies involving the partial area under the curve (AUC) or sensitivity at a fixed false-positive rate (FPR). The program also computes sample size/power for the area under the full curve, but because it requires estimates of parameters A and B (see below), it may not be as user-friendly as rocpower.sas (unless estimates of A and B are readily available). This program is for situations involving the comparison of two curves (paired or unpaired design). You will first need to copy the program DESIGNROC.for into your home directory. Then you will need to issue the following statements in your command tool after the % prompt: source /vol/vni/ipt/bin/iptsetup.csh f77 DESIGNROC.for -o designroc designroc The program will then prompt you for information which you will enter directly into the command tool window. You will need to have estimates of parameters A and B for each curve (under the alternative hypothesis that there is a difference) and for both curves under the null hypothesis (i.e., AUC1=AUC2). A is the standardized difference between the diseased and nondiseased populations for a single curve. In other words, A = (meanD - meanN)/S(diseased) where 'meanD' is the mean rating (or continuous measurement) among diseased patients 'meanN' is the mean rating (or continuous measurement) among normal patients 'S(diseased)' is the standard deviation of the rating (or conts measurement) among diseased patients B is the ratio of the standard errors of the ratings (or continuous measurements) of normal and diseased patients; specifically, B= S(normal)/S(diseased)