Research Core Services

The Lerner Research Institute's Core Services seek to facilitate and advance research throughout Cleveland Clinic by providing technologies that support basic, translational, and clinical research.

Research Cores

learn more


learn more


learn more

Genomics Core

About Us

Welcome to the Genomics Core of Cleveland Clinic’s Lerner Research Institute (LRI)! Our mission is to provide easy access to state-of-the-art DNA and RNA services to Cleveland Clinic’s investigators and to both external academic and commercial users.

The Genomics Core uses cutting-edge genomics technology to generate top-quality data with a rapid turn-around time and an affordable cost. We offer a wide range of services, including capillary sequencing and genotyping, Illumina microarray-based gene expression profiling and genotyping, and next-generation sequencing (NGS). Our lab is equipped with the renowned Illumina MiSeq desktop sequencer and the Illumina HiSeq2500, which enable rapid and effective targeted and whole genome analyses. We prepare and normalize libraries for RNA-seq, miRNA-seq, DNA-Seq, ChIP-seq, targeted exome sequencing, amplicon sequencing, bacterial 16S metagenomics and whole genome sequencing. Other services include DNA/RNA QC on an Agilent Technologies Bioanalyzer, shearing of DNA and chromatin with Covaris technology, and microarray data analysis support. We also collaborate with the Genomic Medicine Biorepository to extract DNA and RNA for our users.

The Genomics Core team can work with individual users to provide services not listed here. We also provide letters of support for federal and nonfederal grant applications and are open to research collaborations. Please contact LRI Genomics Core at or 216-444-7124 for service requests and daily communication. All scientific questions/questions on design should be directed to Dr. Cheng at All requests for letters of support for grant applications should be directed to Dr. Eng at

Questions can be directed to

Come visit us in the LRI at:
LRI Genomics Core
Cleveland Clinic
9500 S Euclid Avenue, Room R4-058
Cleveland, OH 44195
Lab: 216-444-7124;

Disclaimer: Data generated by the Genomics Core are for research purposes only. They are not intended or certified for diagnostic or clinical use. All services provided by the Genomics Core should be appropriately acknowledged in scientific publications, posters, and presentations. Furthermore, Core personnel should be recognized as co-authors for substantial intellectual contribution to projects.