Anthony Calabro Ph.D.

Contract Staff

  • Department of Biomedical Engineering (ND20)
  • Cleveland Clinic Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • calabra@ccf.org
  • (216) 445-3273
  • (216) 444-9198

Research interest

Dr. Calabro's research interests focus on the development of novel biomaterials composed of naturally occurring macromolecules, such as hyaluronan and collagen, for use in a number of clinically relevant tissue engineering and repair applications. Current research areas include: cartilage repair, inflammatory diseases such as rheumatoid arthritis, tendon repair, artificial pancreas, urinary and fecal incontinence, fertility, facial reconstruction and soft tissue repair, mitral annular remodeling, and kidney biology.

Issued U.S. Patents: U.S. Patent #6,982,298, #7,368,502 #7,465,766, and #8,021,350.

Issued Foreign Patents:  Australia #2004204465, #2005265326, China #200480005571.9, India #214247).

Licenses: Lifecore Biomedical, Inc.

In other words ...

My research focuses on purifying molecules (carbohydrates and proteins) that occur naturally in humans (those structural molecules that are required for healthy tissue function), and forming them through a unique, patented method into "synthetic tissues" that mimic healthy tissue function for application to tissue engineering and repair.

US Patent Patent Title Issue Date First-Named Inventor
8658593 Treatment of Extracellular Matrix to Reduce Inflammation 2/25/2014 Anthony Calabro Ph.D.
8,410,180 Methods To Treat Urinary Incontinence 4/2/2013 Anthony Calabro Ph.D.
8,207,262 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 6/26/2012 Anthony Calabro Ph.D.
8,138,265 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 3/20/2012 Anthony Calabro Ph.D.
8,021,350 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 9/20/2011 Anthony Calabro Ph.D.
7,465,766 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 12/16/2008 Anthony Calabro Ph.D.
7,368,502 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 5/6/2008 Anthony Calabro Ph.D.
6,982,298 Hydroxyphenyl Cross-Linked Macromolecular Network and Applications Thereof 1/3/2006 Anthony Calabro Ph.D.

Darr, A. and Calabro, A. (2009) Synthesis and characterization of tyramine-based hyaluronan hydrogels. J Mater Sci: Mater Med 20: 33-44.

Fumoto, H., Takaseya, T., Shiose, A., Saraiva, R.M., Arakawa, Y., Park, M., Rao, S., Dessoffy, R., Chen, J-F., Zhou, Q., Calabro, A., Jr., Banbury, M., Fukamachi, K. (2010) Mitral annular remodeling to treat functional mitral regurgitation: An acute pilot study in a canine model. Heart Surgery Forum 13: E247-E250.

Desai, N., Alex, A., Abdel-Hafez, F., Calabro, A., Goldfarb, J., Fleischman, A., Falcone, T. (2010) Three-dimensional in vitro follicle growth: Overview of culture models, biomaterials, design parameters and future directions. Reproductive Biology and Endocrinology 8:119.

Chin, L-K., Calabro, A., Rodriguez, E.R., Tan, C.D., Walker, E., Derwin, K.A. (2011) Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix. Journal of Materials Science: Materials in Medicine DOI 10.1007/s10856-011-4325-4.