Dr. Calabro's research interests focus on the development of novel biomaterials composed of naturally occurring macromolecules, such as hyaluronan and collagen, for use in a number of clinically relevant tissue engineering and repair applications. Current research areas include: cartilage repair, inflammatory diseases such as rheumatoid arthritis, tendon repair, artificial pancreas, urinary and fecal incontinence, fertility, facial reconstruction and soft tissue repair, mitral annular remodeling, and kidney biology.
Issued U.S. Patents: U.S. Patent #6,982,298, #7,368,502 #7,465,766, and #8,021,350.
Issued Foreign Patents: Australia #2004204465, #2005265326, China #200480005571.9, India #214247).
My research focuses on purifying molecules (carbohydrates and proteins) that occur naturally in humans (those structural molecules that are required for healthy tissue function), and forming them through a unique, patented method into "synthetic tissues" that mimic healthy tissue function for application to tissue engineering and repair.
Darr, A. and Calabro, A. (2009) Synthesis and characterization of tyramine-based hyaluronan hydrogels. J Mater Sci: Mater Med 20: 33-44.
Fumoto, H., Takaseya, T., Shiose, A., Saraiva, R.M., Arakawa, Y., Park, M., Rao, S., Dessoffy, R., Chen, J-F., Zhou, Q., Calabro, A., Jr., Banbury, M., Fukamachi, K. (2010) Mitral annular remodeling to treat functional mitral regurgitation: An acute pilot study in a canine model. Heart Surgery Forum 13: E247-E250.
Desai, N., Alex, A., Abdel-Hafez, F., Calabro, A., Goldfarb, J., Fleischman, A., Falcone, T. (2010) Three-dimensional in vitro follicle growth: Overview of culture models, biomaterials, design parameters and future directions. Reproductive Biology and Endocrinology 8:119.
Chin, L-K., Calabro, A., Rodriguez, E.R., Tan, C.D., Walker, E., Derwin, K.A. (2011) Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix. Journal of Materials Science: Materials in Medicine DOI 10.1007/s10856-011-4325-4.
Lerner Research Institute
Mail Code NB21
9500 Euclid Avenue
Cleveland, Ohio 44195