Lerner Research Institute News

Read about the latest advances from Lerner Research Institute scientists, including new findings, grant awards, innovations and collaborations.

 

Investigating Age Differences in COVID-19 Immune Response
01/13/2022

Dr. Cheng’s team identified several differences in immune and inflammatory responses that may help explain the elevated risk for severe illness and death observed in older COVID-19 patients.

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Adaptive Differentiation Drives Cell Repair in Diseased Tissues
01/12/2022

Dr. Stappenbeck’s group found a new cell type that is produced by intestinal epithelial stem and progenitor cells and provides rapid structural support to damaged, high-turnover tissue and a foundation for its proper healing.

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Researchers Probe Further Into Link between Red Meat and Cardiovascular Disease Risk
12/23/2021

Dr. Hazen identified the gbu gene cluster as a potential therapeutic target for diet-associated cardiovascular disease, and showed that dietary modifications may also help reduce risk.

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Three-Dimensional Organoid Models May Help Improve Drug Therapy for Brain Tumors
12/22/2021

In their study, Drs. Hubert, Sundar and Shakya, and colleagues suggest that organoids can model patient-like drug resistance similar to that seen in human brain tumors.

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NIH Funds Collaborative Study into Mechanisms of Glioblastoma Treatment Resistance
12/14/2021

Drs. Yu and Zhao will study the role of a long non-coding RNA called Lucat1 in glioma stem cells in the search for new therapeutics to help treat glioblastoma and overcome treatment resistance.

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Researchers to Study if Non-Coding SARS-CoV-2 Genetic Material Can Offer Insights into New COVID-19 Therapies
12/09/2021

Led by Dr. Fox, researchers from Cleveland and Florida will collaborate to investigate if certain regions of SARS-CoV-2 genetic material, called non-coding RNA, can be targeted to treat or prevent COVID-19 infection.

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Harnessing Endophenotypes for Alzheimer’s Disease Drug Repurposing
12/06/2021

Dr. Cheng’s team developed an endophenotype-based drug repurposing methodology that identified the FDA-approved drug sildenafil as a candidate for the prevention and treatment of Alzheimer’s disease.

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NIH Grant to Advance the Study of Chronic Kidney Disease in African Americans
11/30/2021

Drs. Bruggeman, Sedor and O’Toole will investigate the pathogenic mechanisms of chronic kidney disease to develop greater understanding of genetic susceptibility and develop new treatment strategies.

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Researchers Investigate Sex Differences in Systemic Lupus Erythematosus
11/29/2021

Dr. Jorgensen and team have uncovered the role of S100a9 as a molecule integral in determining sex-specific immune responses in lupus.

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Failed Alzheimer’s Drug May Hold Promise for Treating Glioblastoma
11/22/2021

Dr. Bao’s team found that treating preclinical models of glioblastoma with verubecestat, a BACE1-inhibiting drug, reduces cancer progression by targeting a class of immune cells abundant in tumors.

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COVID-19 Infection During Pregnancy Leads to Distinct Immune Changes in Mothers and Babies
11/19/2021

Dr. Jung’s team studied blood samples collected from mothers with COVID-19 and their infant children who were exposed to SARS-CoV-2 to understand how infection modulates the expression of different inflammatory molecules.

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New NIH Grant to Study the Effect of Alcohol on Sepsis
11/08/2021

Dr. Vachharajani and her team will study the immuno-metabolic mechanisms that trigger dysfunction in alcohol consumption with sepsis to identify new therapeutic targets for expanded treatments.

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Machine Learning Model Uses Clinical and Genomic Data to Predict Immunotherapy Effectiveness
11/02/2021

With further validation, the tool developed by Dr. Chan may help oncologists better identify patients most likely to benefit from immune checkpoint blockade therapy.

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Using Virtual Reality to Understand and Develop Treatments for Symptoms of Parkinson’s Disease
11/01/2021

In this three-year clinical study, Drs. Alberts and Baker will utilize virtual reality technology to isolate the causes of freezing of gait, a debilitating symptom of Parkinson’s disease, thanks to support from the Michael J. Fox Foundation for Parkinson’s Research.

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Study Links the Gut Microbiome and Aggressive Prostate Cancer
10/28/2021

Dr. Sharifi and collaborators identified choline, betaine and phenylacetylglutamine as nutrients and gut microbiome metabolites associated with increased risk for lethal prostate cancer, suggesting dietary interventions may help reduce disease risk.

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Researchers Open Clinical Trial for Triple-Negative Breast Cancer Vaccine
10/26/2021

Dr. Tuohy and his research team will begin vaccinating patients in a phase I trial to study how their triple-negative breast cancer vaccine immunizes against the protein alpha-lactalbumin.

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Researchers to Conduct Comprehensive Analysis of the Human Bladder and Ureter
10/25/2021

Drs. Lee, Ting and Wessely will examine human ureter and bladder tissues in males and females at various ages and construct a cellular and molecular anatomical map of the organs.

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The Consequences of Diet on Brain Cancer Severity and Disease Pathology
10/25/2021

Drs. Lathia, Silver and Hine report that a high-fat diet causes hydrogen sulfide dysfunction and leads to more severe disease with poorer outcomes among preclinical glioblastoma models.

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Cleveland Clinic and Brooks Automation Open State-of-the-Art BioRepository
10/07/2021

The facility, the first new building in the Cleveland Innovation District, will be located in the Fairfax neighborhood and house 400 freezers for biological samples that will advance research.

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Dr. Michaela Gack Receives Prestigious NIH Director’s Pioneer Award
10/05/2021

Dr. Gack has received a five-year, $5.6 million award as part of NIH’s High-Risk, High-Reward Research Program to study novel approaches to target viral pathogens, which may help inform the development of new antiviral therapies.

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Large $12M Grant to Support Team Science into the Biology of Cardiovascular Disease
09/30/2021

Dr. Plow is the program director for a recently awarded program project grant from the National Institutes of Health that will enable research into the function of integrins in blood and vascular cells, and how their interactions with other proteins may drive disease.

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Computational Biologist Dr. Ming Hu Receives $2.4M NIH Genomic Innovator Award
09/30/2021

Dr. Hu is one of 11 researchers across the country to receive the prestigious grant for early-career genomics researchers.

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Investigating the Influence of Genetic Ancestry on Colorectal Cancer Outcomes
09/24/2021

Dr. Schmit’s team will study the role of genetic ancestry in shaping immune-related determinants of colorectal cancer outcomes.

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Researchers to Study Link Between Platelets and Asymptomatic Abdominal Aortic Aneurysms
09/21/2021

Dr. Cameron will study the mechanistic interaction between platelets and how they emerge as circulating biosensors, releasing proteins that are useful biomarkers for distinguishing fast- from slow-growing aneurysms.

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