Lerner Research Institute

Home to basic, translational and clinical research at Cleveland Clinic, a top U.S. hospital.

News

Researchers Engineer Novel Disease Model to Develop New Ulcerative Colitis Drugs
01/11/2021

Dr. Huang developed an innovative patient-derived model of the chronic inflammatory bowel disease that mirrors the disease’s complexity better than others currently available and identified the protein CXCL8 as an actionable drug target.

Study Shows Machine Learning’s Potential to Predict Cancer Therapy-Related Cardiac Risk
01/06/2021

An interdisciplinary team led by Drs. Cheng and Collier developed machine learning models that predict with promising accuracy the risk of cardiac dysfunction in cancer survivors and may be generalizable to clinical practice.

Potential New Target for Treating Chemotherapy-Associated Kidney Damage
12/31/2020

Dr. Zhao and his team found that inhibiting the APE2 protein in a preclinical model of cisplatin-induced acute kidney injury significantly helped attenuate disease pathology.

Institute News

COVID-19: Our Response

The best and brightest scientists, researchers and clinicians are working together to study treatments and prevention strategies to overcome the novel coronavirus (SARS-CoV-2) causing COVID-19. Explore our latest research news and discoveries.

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Accelerating Discoveries to Patients

Working together with Cleveland Clinic physicians, our scientists are discovering the treatments of tomorrow. While many spend their days working at the laboratory bench, their inspiration can be found at the patient bedside.