Lerner Research Institute

Home to basic, translational and clinical research at Cleveland Clinic, a top U.S. hospital.



Not All Mutations are Bad: Researchers Identify Differences between Benign and Pathogenic Variants

Dr. Lal’s team conducted the first big data characterization of missense variants from 1,300 disease-associated genes to identify features associated with pathogenic and benign variants.

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Possible Target Identified to Prevent Recurrent Blood Vessel Blockages Following Vascular Procedures

The TRPC6 gene plays a role in arterial healing after an injury, according to a new study led by Dr. Graham. This could lead to the development of therapies to reduce the occurrence of intimal hyperplasia and stenosis.

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Advancing the Study of Rare Genetic Disorder Shwachman-Diamond Syndrome

Dr. Corey and team have successfully genetically engineered a model of zebrafish that mimics Shwachman-Diamond Syndrome pathologies observed in patients, which will help advance research into developing new therapies to treat the disease.

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Institute News

COVID-19: Our Response

The best and brightest scientists, researchers and clinicians are working together to study treatments and prevention strategies to overcome the novel coronavirus (SARS-CoV-2) causing COVID-19. Explore our latest research news and discoveries.

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Accelerating Discoveries to Patients

Working together with Cleveland Clinic physicians, our scientists are discovering the treatments of tomorrow. While many spend their days working at the laboratory bench, their inspiration can be found at the patient bedside.

Education & Training

Postdoctoral Program

Train on the cutting-edge of research and join our thriving postdoc association.

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Molecular Medicine PhD Program

Earn your PhD through our unique program that combines basic science and medical knowledge.

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Graduate Programs

Earn your PhD through our joint program with local universities.

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