About Us
The mission of the Department of Cancer Biology is to build bridges and teams to drive the best ideas in basic and translational cancer biology and developmental therapeutics to achieve breakthrough advances in the prevention, treatment and cure of cancer.
The department faculty are international leaders in brain, colorectal and prostate cancers, leukemia and myeloma, as well as cancer stem cells, mechanisms of DNA damage and repair, and fundamental molecular and cellular processes that impact microbial infections and cancer. Identifying the molecular mechanisms involved in the development and progression of human cancers as well as in normal cellular regulatory processes is our goal, enabling us to achieve our long-term objective of rapidly translating research into strategies that improve patient outcomes.
Featured Lab
Robert Silverman Lab
The Silverman lab studies innate immunity, tumor suppression and fundamental processes in viral infections and cancer.
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Featured Lab
Jennifer Yu Lab
The Jennifer Yu lab studies glioblastoma and mechanisms underlying stem cell maintenance and therapeutic resistance.
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Featured Lab
Jianjun Zhao Lab
The Jianjun Zhao lab investigates deregulated coding and noncoding genes in the initiation of multiple myeloma.
Learn MoreResearch News
The clinical trial strategy was developed through research on a gene associated with treatment-resistant prostate cancer, HSD3B1, and is in clinical trials at nine sites across the U.S.
Cleveland Clinic research into anti-viral immunity identified a novel mechanism in necroptosis, a form of programmed cell death
Team led by Cleveland Clinic's Robert Silverman, PhD, collaborates with Rockefeller University to explore effects of genetic mutations to proteins OAS and RNase L.