The Northern Ohio Alcohol Center (NOAC) is an NIAAA/NIH funded P50 Developmental/Exploratory Center that takes advantage of the many strengths of the world-class research community at Cleveland Clinic, Case Western Reserve University and our colleagues across northern Ohio to address the important public health issue of alcohol-associated liver disease (ALD) and the impact of alcohol on other organs. The NOAC is an interdisciplinary team of investigators expert in measuring in vivo markers of biochemical and molecular stress, as well as assessing the cellular/organismal responses to that stress. Basic scientists and clinical investigators will interact not only to translate basic science advances to clinical investigations (bench to bedside), but also to translate the clinical experience into refining and advancing the approach of basic research studies (bedside to bench) on the mechanisms for ALD and tissue injury.
Our long-term goal is to promote interdisciplinary investigations into understanding the molecular targets of ethanol-induced organ damage, as well as the cellular and systemic responses to damage, in order to rationally design and test therapeutic interventions to either slow and/or reverse the progression of ALD and injury to other organs.
Multidisciplinary researchers in the Northern Ohio Alcohol Center focus on alcohol-associated liver disease and interactions between other organs including gut, skeletal muscle, adipose tissue and brain.Learn More