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About
Science
- Scientific Programs
- Laboratories
- Office of Research Development
- Clinical Research
  
  Participating in Research
- Departments
  
  Biomedical Engineering Cancer Sciences Computational Life Sciences Florida Research & Innovation Center Genomic Sciences & Systems Biology
  
  Heart, Blood & Kidney Research Inflammation & Immunity Microbial Sciences in Health Neurosciences Ophthalmic Research Quantitative Health Sciences
- Centers & Programs
  
  Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Cell Therapy & Immunoengineering Program Consortium for Pain Genitourinary Malignancies Research Genome Center Global Center for Immunotherapy & Precision Immuno-Oncology Microbiome & Human Health
  
  Musculoskeletal Research Neuro-Oncology Program Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Quantitative Metabolic Research Therapeutics Discovery Translational and Correlative Sciences Service Tumor Pathophysiology & Evolution Program Women's Cancers Program
Core Services
- All Cores
- Ohio
  
  3D Printing Bioimage Analysis BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Oncology Platform Discovery Lab Electron Microscopy Electronics Engineering
  
  Flow Cytometry Genomic Medicine Institute Biorepository Genomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic
  
  Lerner Research Institute BioRepository Light Microscopy Mechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics SomaScan & Biomarker
- Florida
  
  Flow Cytometry
  
  Imaging
Education & Training
- Research Education & Training Center
- Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
  
  Global Research Education Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
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- Faculty Positions Research Associate & Project Staff Postdoctoral Positions Technical & Administrative Engagement
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Tumor Pathophysiology & Evolution Program

Researching the biology of cancer and tumor ecosystems to accelerate treatment

The Tumor Pathophysiology and Evolution Program investigates the fundamental biological and molecular mechanisms that drive cancer evolution and resistance to therapy -- providing a research foundation for development of novel therapeutic strategies.

More About Us

Tumor pathophysiology spans tumor initiation to malignant transformation, invasion and metastasis, to acquisition of therapeutic resistance.  Our mission is to develop therapeutic intervention at each stage, and better understand the ways in which tumors evolve.

We investigate all the processes surrounding tumor development — including oncogenic signaling, epigenetic dysregulation, tumor metabolism, hypoxia, and the microenvironment. Researchers within the program employ cutting-edge technologies such as CRISPR-based functional genomics, multi-omics profiling, advanced in vivo modeling, and patient specimen analyses to unravel these complexities of cancer biology.

Focus Areas

Epigenetics
Cancer metabolism
Cellular responses to hypoxia
Cancer neuroscience
Cancer ecosystem
Intrinsic and acquired therapeutic resistance
Screening and preclinical studies of novel drugs
Multi-omics
Functional genomics
Advanced in vivo modeling

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