Richard A. Padgett, Ph.D. Staff Department of Molecular Genetics Lerner Research Institute / NE20 9500 Euclid Avenue Cleveland, Ohio 44195 Telephone: (216) 445-2692 Fax: (216) 444-0512 Email: padgetr@ccf.org

Area of general research interest:

Mechanisms of RNA splicing in vivo and in vitro.

Current program:

• Exploring the splicing mechanism of a novel class of nuclear pre-mRNA introns.
• Understanding the chemical mechanisms of splicing reactions.
• Investigating the expression program of very large human genes.
• Investigating the evolutionary history of introns, genes and genomes.

Investigators:

• Agyeman, Akwasi, Ph.D.
• Brock, Jay, Ph.D.
• Saikia, Sakuntala
• Singh, Jarnail, Ph.D.
• Dietrich, Rosemary, M.S.

Collaborators:

• Burge, Christopher B., Ph.D., Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
• Dayie, Kwaku, Ph.D., Department of Molecular Genetics, Cleveland Clinic