Bela  Anand-Apte,  MBBS, PhD

Bela Anand-Apte, MBBS, PhD

Department Chair

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195


Laboratory Goals

  • Understanding the basic molecular mechanisms of ocular neovascularization with a special focus on Tissue Inhibitors of Metalloproteinases-3 (TIMP-3) and Sorsby Fundus Dystrophy
  • Examination of the physiological and pathological pathways that regulate breakdown of the blood-retinal barrier in diabetic retinopathy

View Publications on PubMed

Qi, JH, Ebrahem, Q, Moore, N, Murphy, G, Claesson-Welsh, L, Bond, M, Baker, A and Anand-Apte, B. (2003) Nature Medicine 9:407-415

Qi J, Dai G, Luthert P, Hollyfield J, Weber B, Heidi Stoehr and Anand-Apte B (2009) Upregulation of VEGF Receptor-2 in Endothelial Cells Expressing S156C-TIMP-3 Mutation Mediates Enhanced Angiogenesis: Implications for Choroidal Neovascularization in Sorsby Fundus Dystrophy. Journal of Biological Chemistry 284:19927-19936

Ebrahem Q, Vasanji A, Qi J, Klenotic P, Cutler A and Anand-Apte B (2010) Cross-talk between Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in the induction of Neovascularization In Vivo. American Journal of Pathology 176(1):496-503.

Xie, J., Farage, E., Sugimoto,M and Anand-Apte,B. (2009) BMC Dev Biol. 2010 Jul 23;10:76

Sugimoto, M, Cutler, A., Shen, B., Moss, SE., Iyengar, SK., Klein, R., Folkman, J and Anand-Apte, B (2013) Inhibition of EGF Signaling Protects the Diabetic retina From Insulin-Induced Vascular Leakage. Am J Pathol 183(3):987-995

Bell, B, Xie, J, Yuan,A, Kaul,C, Hollyfield, JG and Anand-Apte, B (2014) Retinal Vasculature Imaging in Adult Zebrafish In Vivo using Confocal Scanning Laser Ophthalmoscopy. Experimental Eye Research 129;107-118

Qi, J and Anand-Apte, B (2014) Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Promotes Endothelial Apoptosis by a Caspase-Independent Mechanism. Apoptosis 2015:20(4):523-534

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