Our lab investigates genetic and epigenetic markers of Alzheimer disease.
Our lab develops computational approaches for analyzing large-scale biological data.
Our lab develops and utilizes innovative network medicine methodologies and systems biology technologies to predict drug targets and identify mechanisms of human diseases, including cardio-oncology, Alzheimer’s disease and pulmonary vascular disease.
Our research identifies and characterizes genes (e.g., PTEN, SDH) that cause susceptibility to inherited cancer syndromes, determines their role in sporadic carcinogenesis and performs molecular epidemiologic analyses as they relate to clinical care in the realm of precision healthcare, with a significant focus on understanding the mechanistic switch between cancer predisposition and autism spectrum disorder in those carrying PTEN mutations.
Our research examines the roles that iron metabolism and mitochondrial function play in chronic inflammatory diseases, including but not limited to HIV-associated neurocognitive disorders.
Our lab focuses on understanding early events in breast cancer with the goal of identifying individualized therapeutic vulnerabilities.
Among many biomedical data science projects, our lab focuses on discovering genes related to epilepsy syndromes, developing novel methods for interpreting missense variants and characterizing patient disease trajectories.
Our lab focuses on identifying and understanding the genes that play a role in neurological disorders (e.g., Parkinson’s disease), with a particular focus on underrepresented populations, especially Latinos.
The overall goal of our lab is to better understand cytomegalovirus infection, pathogenesis and disease.
Our lab focuses on understanding the roles of germline and somatic genetics, host immune responses, lifestyle factors, and environmental variables in colorectal cancer development and the modulation of disease progression and outcomes.
Our research examines the mechanisms of epigenetic gene silencing and the functional relevance of DNA methylation in cancer.
Our research investigates the role of protein secretion dysregulation in disease development and aims to find novel treatments of these diseases by targeting protein secretion pathways.