Associate Staff
Scientific Director, Flow Cytometry Core
Email: asosink@ccf.org
Location:
Cleveland Clinic Main Campus
The Asosingh lab provides preclinical testing in experimental models of asthma and pulmonary arterial hypertension and perform collaborative research of how abnormal blood vessels and bone marrow stem cells contribute to lung diseases.
1: Rose JA, Wanner N, Cheong HI, Queisser K, Barrett P, Park M, Hite C, Naga
Prasad SV, Erzurum S, Asosingh K. Flow Cytometric Quantification of Peripheral
Blood Cell β-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived
Microparticles in Pulmonary Arterial Hypertension. PLoS One. 2016 Jun
7;11(6):e0156940. doi: 10.1371/journal.pone.0156940. eCollection 2016. PubMed
PMID: 27270458; PubMed Central PMCID: PMC4896479.
2: Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD,
Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan
SC, Erzurum SC. Increased mitochondrial arginine metabolism supports
bioenergetics in asthma. J Clin Invest. 2016 May 23. pii: 82925. doi:
10.1172/JCI82925. [Epub ahead of print] PubMed PMID: 27214549.
3: Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A,
Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ.
Soluble guanylate cyclase as an alternative target for bronchodilator therapy in
asthma. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2355-62. doi:
10.1073/pnas.1524398113. Epub 2016 Apr 11. PubMed PMID: 27071111; PubMed Central
PMCID: PMC4855555.
4: Asosingh K, Vasanji A, Tipton A, Queisser K, Wanner N, Janocha A, Grandon D,
Anand-Apte B, Rothenberg ME, Dweik R, Erzurum SC. Eotaxin-Rich Proangiogenic
Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic
Response. J Immunol. 2016 Mar 1;196(5):2377-87. doi: 10.4049/jimmunol.1500770.
Epub 2016 Jan 25. PubMed PMID: 26810221; PubMed Central PMCID: PMC4761512.
5: Gupta MK, Asosingh K, Aronica M, Comhair S, Cao G, Erzurum S, Panettieri RA
Jr, Naga Prasad SV. Defective Resensitization in Human Airway Smooth Muscle Cells
Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma. PLoS One. 2015 May
29;10(5):e0125803. doi: 10.1371/journal.pone.0125803. eCollection 2015. PubMed
PMID: 26023787; PubMed Central PMCID: PMC4449172.
6: Barnes JW, Tian L, Heresi GA, Farver CF, Asosingh K, Comhair SA, Aulak KS,
Dweik RA. O-linked β-N-acetylglucosamine transferase directs cell proliferation
in idiopathic pulmonary arterial hypertension. Circulation. 2015 Apr
7;131(14):1260-8. doi: 10.1161/CIRCULATIONAHA.114.013878. Epub 2015 Feb 6. PubMed
PMID: 25663381; PubMed Central PMCID: PMC4390469.
7: Roach EC, Park MM, Tang WH, Thomas JD, Asosingh K, Kalaycio M, Erzurum SC,
Farha S. Impaired right ventricular-pulmonary vascular function in
myeloproliferative neoplasms. J Heart Lung Transplant. 2015 Mar;34(3):390-4. doi:
10.1016/j.healun.2014.09.009. Epub 2014 Sep 28. PubMed PMID: 25638299; PubMed
Central PMCID: PMC4377111.
8: Farha S, Dweik R, Rahaghi F, Benza R, Hassoun P, Frantz R, Torres F, Quinn DA,
Comhair S, Erzurum S, Asosingh K. Imatinib in pulmonary arterial hypertension:
c-Kit inhibition. Pulm Circ. 2014 Sep;4(3):452-5. doi: 10.1086/677359. PubMed
PMID: 25621158; PubMed Central PMCID: PMC4278604.
9: Rose JA, Erzurum S, Asosingh K. Biology and flow cytometry of proangiogenic
hematopoietic progenitors cells. Cytometry A. 2015 Jan;87(1):5-19. doi:
10.1002/cyto.a.22596. Epub 2014 Nov 21. Review. PubMed PMID: 25418030; PubMed
Central PMCID: PMC4356492.
10: Lanzola E, Farha S, Erzurum SC, Asosingh K. Bone marrow-derived vascular
modulatory cells in pulmonary arterial hypertension. Pulm Circ. 2013
Dec;3(4):781-91. doi: 10.1086/674769. Review. PubMed PMID: 25006394; PubMed
Central PMCID: PMC4070843.
11: Ratanamaneechat S, Neumann DR, Difilippo FP, Comhair SA, Asosingh K, Ghosh S,
Grandon D, Khan A, Aronica MA, Erzurum SC. Redox imaging of inflammation in
asthma. Am J Respir Crit Care Med. 2014 Mar 15;189(6):743-6. doi:
10.1164/rccm.201310-1872LE. PubMed PMID: 24628314; PubMed Central PMCID:
PMC3983839.