Cleveland Clinic Lerner Research Institute Logo
Cleveland Clinic Lerner Research Institute Logo
  • About
  • Science
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Consortium for Pain Genitourinary Malignancies Research
      Microbiome & Human Health Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute Biorepository Genomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • About
  • Science
    • Scientific Programs
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Consortium for Pain Genitourinary Malignancies Research
      Microbiome & Human Health Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • All Cores
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute BiorepositoryGenomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Research Education & Training Center
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • Search

Anna Valujskikh Laboratory

❮Inflammation & Immunity Anna Valujskikh Laboratory
  • Anna Valujskikh Laboratory
  • Principal Investigator
  • Research
  • Our Team
  • Publications
  • Research News

Principal Investigator

Anna Valujskikh Headshot

Anna Valujskikh, PhD

Staff
Email: valuysa@ccf.org
Location: Cleveland Clinic Main Campus

Research


Biography


Education & Professional Highlights

Medical Education - Moscow State University
Immunology
1996

Graduate School - Moscow State University
Cell Physiology and Immunology
1994

Research

Research

Immunologic memory is the ability of the immune system to respond rapidly and more efficiently to the previously encountered pathogens. While memory T cells are essential for host protection against infections, they can be harmful for life-saving organ transplants. Studies in laboratory animals and humans confirm that the high frequency of donor-reactive memory T cells prior to transplantation correlates with poor allograft outcome. The focus of our group is immunolobiology of memory CD4 T cells in general and the functions of donor-reactive memory CD4 T cells during allograft rejection in particular. We have previously demonstrated that memory CD4 T cells contribute to allograft rejection through multiple pathways. Such a redundancy of effector mechanisms makes controlling memory T cells in alloraft recipient a very challenging problem. Indeed, alloreactive memory T cells appear to be resistant to currently used graft-prolonging strategies including lymphoablation, immunosuppressive drugs and conventional costimulatory blockade. Our ultimate goal is to better understand the functions of graft-reactive memory CD4 T cells in the context of transplantation. This information should enable us to target various aspects of memory T cell response and promote rational development of combinatorial therapies for sensitized transplant recipients.

Our Team

Our Team

Publications

Selected Publications

View publications for Anna Valujskikh, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)


Schenk, A., Gorbacheva, V., Rabant, M., Fairchild, RL., Valujskikh, A. Effector function of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts. Am. J. Transplantation, 2009, 9:64-73.

Gorbacheva, V., Fan, R., Li, X., Valujskikh, A. Interleukin-17 promotes early allograft inflammation. American Journal of Pathology, 2010, 177:1265-1273.

Sicard A, Phares TW, Yu H, Fan R, Baldwin WM 3rd, Fairchild RL, Valujskikh A. The spleen is the major source of antidonor antibody-secreting cells in murine heart allograft recipients. Am. J. Transplantation, 2012, 12:1708-1719.

Ayasoufi, K., Yu, H., Fan, R., Wang, X., Williams, J.,Valujskikh, A. Pre-transplant antithymocyte globulin has increased efficacy in controlling donor-reactive memory T cells in mice. Am. J. Transplantation, in press.

 

Research News

Research News

...
$3 Million NIH Grant to Support Research into Preventing Post-Transplant Organ Rejection

Dr. Valujskikh will investigate how immune cell subpopulations produce pathogenic antibodies following organ transplant that can threaten outcomes, including organ acceptance and function and patient survival, in an effort to develop new therapies for antibody-mediated rejection.



About Lerner

About Us Careers Contact Us Donate People Directory

Science

Clinical & Translational Research Core Services Departments, Centers & Programs Laboratories Research News

Education & Training

Graduate Programs Molecular Medicine PhD Program Postdoctoral Program RISE Program Undergraduate & High School Programs

Site Information & Policies

Search Site Site Map Privacy Policy Social Media Policy

9500 Euclid Avenue, Cleveland, Ohio 44195 | © 2023 Lerner Research Institute