Aaron Fleischman, Ph.D.
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-3218
Fax: (216) 444-9198
Recent progress in microelectromechanical systems (MEMS) is being applied to biomedical applications and has become a new field of research unto itself, known as BioMEMS. BioMEMS is an enabling technology for ever-greater functionality and cost reduction in smaller devices for improved medical diagnostics and therapies based upon the same technology used for computer chips.
For example, BioMEMS technology can enhance catheter-based procedures by providing pressure sensing, imaging, drug delivery and tissue sampling, all via tiny biochips. On the nanoscale, BioMEMS can be used to engineer micro-/nanometer-sized features for tissue engineering, protein analyses, assays, and cell interrogation.
Areas of application under investigation include miniature high-performance ultrasonic transducers, which integrate electronics and piezoelectric transducers on a single chip to create high-quality ultrasonic images; miniature drug delivery systems, capable of delivering high concentrations of drugs to local areas of tissue while maintaining low systemic concentrations; biochips for cell detection and manipulation; surface textures and systems to enhance tissue engineering of bioartificial tissues and organs; and the design and development of miniature in situ sensors for pressure, temperature strain and flow for minimally invasive and noninvasive surgical procedures and post-surgical follow-up.
My laboratory concentrates on the application of micro and nano technology to biomedical applications. The research focuses on two broad categories of the science of miniaturization. One, we investigate how to shrink high-functioning large systems into small computer-like chips for implantation or minimally invasive procedures. Two, we take advantage of the physics unique to very small things to enable new capabilities and technologies for unmet medical needs. All work is focused on improving patient outcomes.
P. Nath, L.R. Moore, M. Zborowski, S. Roy, and A.J. Fleischman, “A novel method to obtain uniform magnetic field energy density gradient distribution using discrete pole pieces for a MEMS (micro-electro-mechanical-systems) based magnetic cell separator”, Journal of Applied Physics, Vol. 99, 2006, p. 08R905
C. Chandrana, N. Kharin, G. D. Vince, S. Roy, and A. J. Fleischman, "Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers," Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on, vol. 57, pp. 1077-1085, 2010.
N. Ferrell, R. R. Desai, A. J. Fleischman, S. Roy, H. D. Humes, and W. H. Fissell, "A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells," Biotechnology and Bioengineering, vol. 107, pp. 707-716, 2010.
C. Chandrana, J. Talman, T. Pan, S. Roy, and A. Fleischman, "Design and Analysis of MEMS Based PVDF Ultrasonic Transducers for Vascular Imaging," Sensors, vol. 10, pp. 8740-8750. 2010
|US Patent||Patent Title||Issue Date||First-Named Inventor|
|7,728,442||Method and Apparatus for In Vivo Sensing||10/23/2007||Aaron Fleischman Ph.D.|
|7,169,106||Intraocular Pressure Measurement System Including a Sensor Mounted in a Contact Lens||1/30/2007||Aaron Fleischman Ph.D.|
|6,749,568||Measurement System Including a Sensor Mounted In a Contact Lens||6/15/2004||Aaron Fleischman Ph.D.|
|6,641,540||Miniature Ultrasound Transducer||11/4/2003||Aaron Fleischman Ph.D.|
|6,623,984||MEMS-Based Integrated Magnetic Particle Identification System||9/23/2003||Aaron Fleischman Ph.D.|
Metastasis of carcinomas (cancers that come from epithelial cells, which line organ surfaces) depends on cancer cells’ ability to travel from the tumor site and spread throughout the body, where the count of circulating tumor cells (CTCs) in the blood can be an indicator of metastatic risk.
A team of researchers in the Department of Biomedical Engineering, led by Aaron Fleischman, PhD, is developing an “intelligent” contact lens to measure intraocular pressure (IOP) throughout the day. This technology could help clinicians better manage patients who have glaucoma, the second leading cause of blindness in the United States.