Department of Biomedical Engineering
Gordon McLennan, M.D.
Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 444-6124
Fax: (216) 445-1492
The primary focus of our research is on how to more effectively deliver drugs to cancer without damaging normal tissues nearby. This includes research in sustained drug delivery, new drug systems with lower toxicity, as well as combinations of imaging, ablation technologies, and drug delivery techniques to improve tumor kill or destroy painful tumors while preserving normal function.
In other words ...
Interventional Radiology (IR) is a very diverse field that touches on all aspects of medicine. The unifying there of IR is the use of x-ray, ultrasound, or MRI imaging to guide treatments. Interventional Radiologists treat stroke, aneurysms, vascular disease, cancer, uterine fibroids, painful cancers and non-cancerous tumors as well as take care of patients on dialysis or with clot in their legs. The focus of our laboratory's research is in the field of liver cancers. Primary liver cancer is the fastest growing cancer in the United States & while current treatments have prolonged people's lives from less than 1 year to 2-3 years, there is much that needs to be done. Our research focuses on new drugs that are less toxic than current drugs & ways to deliver the drugs directly to the tumors through the blood vessels that feed them. If we can deliver less toxic drugs with more specific treatment methods, we should be able to prolong the lives of people with liver cancer.
Siskin GP, Haskal ZJ, McLennan G, Dake MD, et. al. Development of a research agenda for evaluation of interventional therapies for chronic cerebrospinal venous insufficiency: proceedings from a multidisciplinary research consensus panel. Journal of Vascular & Interventional Radiology. 22(5):587-93, 2011 May.
Babsky AM, Ju S, George B, Bennett S, Huang M, Jayaram HN, McLennan G, Bansal N. Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water. Anticancer Research. 31(6):2045-51, 2011 Jun.
Lance C, McLennan G, Obuchowski N, Cheah G, et. al. Comparative Analysis of the Safety and Efficacy of Transcatheter Arterial Chemoembolization and 90Y Radioembolization in patients with Unresectable Hepatocellular Carcinoma. Submited & Revised for JVIR. In Press.
Effect of Implantation Site and Growth of Hepatocellular Carcinoma on Apparent Diffusion Coefficient of Water and Sodium MRI Submitted & Revised for NMR in Biomedicine. In Press.