Stanley L. Hazen, M.D., Ph.D.

Chairman

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NC1-127
hazens@ccf.org
Phone: (216) 445-9763
Fax: (216) 444-9404



A long term goal of my laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma. Several major research programs are currently under investigation. One research program focuses on the role of myeloperoxidase, a leukocyte heme protein, in promoting oxidant stress in vivo, and its participation in cardiovascular diseases. A second area focuses on HDL structure and function. A final area of research interest focuses on the role of intestinal microbiota in cardiometabolic disease.

All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, andhuman clinicalinvestigations.

In other words ...

A long term goal of my laboratory is to understand the ways in which our immune system contributes to diseases like heart disease and asthma. I have several major areas of focus. One centers on the role of myeloperoxidase, a protein found in white blood cells that plays an important role in fighting infections, but which we have discovered also participates in development of heart diseases. A second area focuses on the role of microbes in our intestines (called gut flora) in heart disease. Another area focuses on the HDL particle (carrier of good cholesterol in the blood). 


Hassan  Alamri
Hassan Alamri
Graduate Student

Location:NE1-224
Phone:(216) 445-6466
hassana@ccf.org
Fax:(216) 444-9404
laboratory

Sarah  Bahr PhD
Sarah Bahr PhD
Fellow

Location:NE1-224
Phone:(216) 445-6466
bahrs@ccf.org
Fax:(216) 444-9404
laboratory

Camelia  Baleanu-Gogonea PhD
Camelia Baleanu-Gogonea PhD
Visiting Scientist

Location:NE1-224
Phone:(216) 445-6466
baleanc@ccf.org
Fax:(216) 444-9404
laboratory

Shawna  Battle
Shawna Battle
Graduate Student

Location:NE1-224
Phone:(216) 445-6466
battles@ccf.org
Fax:(216) 444-9404
laboratory

Nancy  Bell
Nancy Bell
Technologist

Location:NE6-217
Phone:(216) 444-5447
belln@ccf.org
Fax:(216) 444-9404
laboratory

Kimberly  Brinson
Kimberly Brinson
Research Technician

Location:NE1-224
Phone:(216) 445-6466
brinsok@ccf.org
Fax:(216) 636-0392
laboratory

Jennifer Ann Buffa M.S.
Jennifer Ann Buffa M.S.
Lead Research Technologist

Location:NE6-216
Phone:(216) 445-1900
leisinj@ccf.org
Fax:(216) 636-0392
laboratory

Ibrahim  Choucair
Ibrahim Choucair
Graduate Student

Location:NE1-224
Phone:(216) 445-6466
choucai@ccf.org
Fax:(216) 444-9404
laboratory

Anthony  DiDonato
Anthony DiDonato
Research Student

Location:NE1-224
Phone:(216) 445-6466
didonaa@ccf.org
Fax:(216) 636-0392
laboratory

Xiao Ming  Fu M.S.
Xiao Ming Fu M.S.
Lead Research Technologist

Location:NE1-224
Phone:(216) 445-6466
fux@ccf.org
Fax:(216) 445-6466
laboratory

Valentin  Gogonea PhD
Valentin Gogonea PhD
Research Scholar

Location:NC1-116
Phone:(216) 444-0472
gogonev@ccf.org
Fax:(216) 636-0392
laboratory

Xiaodong  Gu Ph.D
Xiaodong Gu Ph.D
Postdoctoral Fellow

Location:NE1-224
Phone:(216) 445-5903
gux2@ccf.org
Fax:(216) 636-0392
laboratory

Anu  Guggilam PhD
Anu Guggilam PhD
Postdoctoral Fellow

Location:NE1-224
Phone:(216) 445-6466
guggila@ccf.org
Fax:(216) 444-9404
laboratory

Nilaksh  Gupta PhD
Nilaksh Gupta PhD
Fellow

Location:NE1-237
Phone:(216) 444-1029
guptan2@ccf.org
Fax:(216) 444-9404
laboratory

Jane Lee Hoover-Plow Ph.D.
Jane Lee Hoover-Plow Ph.D.
Staff Consultant

Location:NB5-85
Phone:(216) 445-8207
hooverj@ccf.org
Fax:(216) 444-8204
laboratory

Ying  Huang Ph.D.
Ying Huang Ph.D.
Research Associate

Location:NE1-224
Phone:(216) 445-6466
huangy2@ccf.org
Fax:(216) 636-0392
laboratory

Alex  Hurd
Alex Hurd
Research Student

Location:NE1-224
Phone:(216) 445-6466
hurda2@ccf.org
Fax:(216) 444-9404
laboratory

Niladri   Kar Ph.D.
Niladri Kar Ph.D.
Fellow

Location:NE1-224
Phone:(216) 445-6466
karn@ccf.org
Fax:(216) 444-9404
laboratory

Lin  Li Ph.D.
Lin Li Ph.D.
Lead Research Technologist

Location:NE6-216
Phone:(216) 445-1900
lil@ccf.org
Fax:(216) 636-0392
laboratory

Xin-Min  Li Ph.D.
Xin-Min Li Ph.D.
Research Associate

Location:NE6-216
Phone:(216) 445-1900
lix2@ccf.org
Fax:(216) 636-0392
laboratory

HongQiao  Lin
HongQiao Lin
Graduate Student

Location:NE1-224
Phone:(216) 445-6466
linh@ccf.org
Fax:(216) 636-0392
laboratory

Ina  Nemet PhD
Ina Nemet PhD
Research Associate

Location:NE1-231
Phone:(216) 445-9578
nemeti@ccf.org
Fax:(216) 444-9404
laboratory

Nisreen  Nimer
Nisreen Nimer
Visiting Grad Student

Location:NE1-224
Phone:(216) 445-6466
nimern@ccf.org
Fax:(216) 444-9404
laboratory

Kara  Rieth
Kara Rieth
Research Student

Location:NE1-224
Phone:(216) 444-6466
riethk@ccf.org
Fax:(216) 444-9404
laboratory

Adam  Roberts PhD
Adam Roberts PhD
Fellow

Location:NE1-224
Phone:(216) 445-6466
roberta3@ccf.org
Fax:(216) 444-9404
laboratory

Prasenjit  Saha Ph.D.
Prasenjit Saha Ph.D.
Fellow

Location:NE1-224
Phone:(216) 445-6466
sahap2@ccf.org
Fax:(216) 444-9404
laboratory

Judith  Schiciano MBA., A.R.M.
Judith Schiciano MBA., A.R.M.
Department Administrator

Location:NC1-129
Phone:(216) 444-8710
schicij@ccf.org
Fax:(216) 444-9404
laboratory

David  Schmitt
David Schmitt
Lead Research Technologist

Location:NE1-224
Phone:(216) 445-6466
schmitd@ccf.org
Fax:(216) 636-0392
laboratory

Zhili  Shao PhD
Zhili Shao PhD
Research Associate

Location:NE6-216
Phone:(216) 445-6466
shaoz@ccf.org
Fax:(216) 444-9404
laboratory

Celalettin  Topbas
Celalettin Topbas
Visiting Scientist

Location:NE1-224
Phone:(216) 445-6466
topbasc@ccf.org
Fax:(216) 636-0392
laboratory

Matthew  Wagner
Matthew Wagner
Senior Technologist

Location:NE1-224
Phone:(216) 445-6466
wagnerm4@ccf.org
Fax:(216) 444-9404
laboratory

Zeneng  Wang PhD
Zeneng Wang PhD
Project Staff

Location:NE1-231
Phone:(216) 445-2484
wangz2@ccf.org
Fax:(216) 636-0392
laboratory

Yuping  Wu PhD
Yuping Wu PhD
Research Scholar

Location:NE1-224
Phone:(216) 445-6466
wuy2@ccf.org
Fax:(216) 636-0392
laboratory

Maryam  Zamanian-Daryoush
Maryam Zamanian-Daryoush
Research Associate

Location:NE6-201
Phone:(216) 444-0484
zamanim@ccf.org
Fax:(216) 636-0392
laboratory

Weifei  Zhu PhD
Weifei Zhu PhD
Project Staff

Location:NE1-231
Phone:(216) 445-9578
zhuw@ccf.org
Fax:(216) 444-9404
laboratory


  1. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature.(2011) 472(7341):57-63. PMCID: PMC3086762
  2. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of  Medicine. (2013) 368(17):1575-84. PMCID: PMC3701945
  3. Koeth RA, Wang Z, Levison BS, Buffa J, Org E, Sheehy B, Li  H, Britt EB, Fu X, Wu Y, Smith JD, DiDonato JA, Chen J, Li H, Wu G, Lewis JD, Warrier M, Brown, JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, and Hazen SL. Intestinal microbiota metabolism of L-Carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine. (2013) 19(5): 576-85. PMCID: PMC36501111
  4. Huang Y, Didonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL. An abundant dysfunctional apolipoprotein A1 form in human atheroma. Nature Medicine. (2014) 20(2):193-203. PMCID: PMC3923163
  5. Gregory JC, Buffa JA, Org E, Wang Z, Levison BS, Zhu W, Wagner MA, Bennett BJ, Li L, DiDonato JA, Lusis AJ, Hazen SL. Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation. The Journal of Biological Chemistry. (2015) 290(9):5647-60 PMCID: PMC4342477
  6. Tang WHW, Wang Z, Kennedy DJ, Wu Y, Buffa J, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL. The Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease. Circulation Research. (2015) 116(3):448-55 PMCID: PMC4312512