Stanley L. Hazen M.D., Ph.D.

Chairman

The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis
The Leonard Krieger Chair in Preventive Cardiology
Director,Center for Cardiovascular Diagnostics & Prevention
Section Head, Preventive Cardiology & Rehabilitation

  • Department of Cellular and Molecular Medicine
  • Lerner Research Institute
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • hazens@ccf.org
  • Phone: (216) 445-9763
  • Fax: (216) 444-9404

A long term goal of my laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and asthma. Several major research programs are currently under investigation. One research program focuses on the role of myeloperoxidase, a leukocyte heme protein, in promoting oxidant stress in vivo, and its participation in cardiovascular diseases. A second area focuses on HDL structure and function. The third area focuses on the role of peroxidases and tobacco exposure in airway remodeling in asthma. A final area of research interest focuses on the role of intestinal microbiota in cardiometabolic disease.

All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations.

In other words ...

A long term goal of my laboratory is to understand the ways in which our immune system contributes to diseases like heart disease and asthma. I have several major areas of focus. One centers on the role of myeloperoxidase, a protein found in white blood cells that plays an important role in fighting infections, but which we have discovered also participates in development of heart diseases. A second area focuses on the role of microbes in our intestines (called gut flora) in heart disease. Another area focuses on the HDL particle (carrier of good cholesterol in the blood). The final area focuses on the role of white blood cells in the lungs in causing asthma.

  • Kimberly Brinson
  • Research Technician
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • brinsok@ccf.org
  • Jennifer Ann Buffa M.S.
  • Senior Technologist
  • Location:NE6-216
  • Phone:(216) 445-1900
  • Fax:(216) 636-0392
  • leisinj@ccf.org
  • Yoon-Mi Chung
  • Senior Technologist
  • Location:NE1-224
  • Phone:(216) 444-3136
  • Fax:(216) 636-0392
  • chungy2@ccf.org
  • Miranda Culley
  • Research Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • culleym2@ccf.org
  • Anthony DiDonato
  • Research Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • didonaa@ccf.org
  • Xiao Ming Fu M.S.
  • Lead Technologist
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 445-6466
  • fux@ccf.org
  • Vivian Gao
  • Research Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • gaov@ccf.org
  • Gary Gerstenecker Ph.D
  • Visiting Scientist
  • Location:NE1-235
  • Phone:(216) 444-4518
  • Fax:(216) 636-0392
  • gersteg@ccf.org
  • Valentin Gogonea PhD
  • Research Scholar
  • Location:NE1-27
  • Phone:(216) 444-4220
  • Fax:(216) 636-0392
  • gogonev@ccf.org
  • Jill Gregory
  • Graduate Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • gregorj2@ccf.org
  • Xiaodong Gu Ph.D
  • Predoctoral Fellow
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • gux2@ccf.org
  • Anu Guggilam PhD
  • Postdoctoral Fellow
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 444-9404
  • guggila@ccf.org
  • Ying Huang Ph.D.
  • Research Associate
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • huangy2@ccf.org
  • Timothy Kim
  • Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • kimt3@ccf.org
  • Bruce Levison Ph.D.
  • Project Scientist
  • Location:NE1-231
  • Phone:(216) 445-9578
  • Fax:(216) 636-0393
  • levisonb@ccf.org
  • Xin-Min Li Ph.D.
  • Research Associate
  • Location:NE-60
  • Phone:(216) 445-1900
  • Fax:(216) 636-0392
  • lix2@ccf.org
  • Lin Li Ph.D.
  • Lead Technologist
  • Location:NE6-216
  • Phone:(216) 445-1900
  • Fax:(216) 636-0392
  • lil@ccf.org
  • HongQiao Lin
  • Graduate Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • linh@ccf.org
  • Shirley Mann
  • Senior Technologist
  • Location:NE6-216
  • Phone:(216) 445-1900
  • Fax:(216) 636-0392
  • manns2@ccf.org
  • David Schmitt
  • Lead Technologist
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • schmitd@ccf.org
  • Daniel Schmitt
  • Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 444-9404
  • schmitd2@ccf.org
  • Celalettin Topbas
  • Visiting Grad Student
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • topbas@ccf.org
  • Matthew Wagner
  • Sr. Technologist
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 444-9404
  • wagnerm4@ccf.org
  • Zeneng Wang Ph.D.
  • Project Scientist
  • Location:NE1-231
  • Phone:(216) 444-3136
  • Fax:(216) 636-0392
  • wangz2@ccf.org
  • Yuping Wu PhD
  • Research Scholar
  • Location:NE1-224
  • Phone:(216) 445-6466
  • Fax:(216) 636-0392
  • wuy2@ccf.org
  • Maryam Zamanian-Daryoush
  • Research Associate
  • Location:NE6-201
  • Phone:(216) 444-0484
  • Fax:(216) 636-0392
  • zamanim@ccf.org
  • Weifei Zhu PhD
  • Research Associate
  • Location:NE1-226
  • Phone:(216) 444-5855
  • Fax:(216) 444-9404
  • zhuw@ccf.org

  • Amber Gist B.S.
  • Department Coordinator
  • Location:NE1-224
  • Phone:(216) 445-1937
  • Fax:(216) 636-0392
  • gista@ccf.org
  • Vannel Hassett C.B.
  • Department Coordinator
  • Location:NC1-126B
  • Phone:(216) 444-0691
  • Fax:(216) 444-9404
  • hassetv@ccf.org


  1. Wang Z, et al. Gut flora dependent metabolism of dietary phosphatidylcholine contributes to cardiovascular disease. Nature (2011) 472(7341):57-63. PMCID: PMC3086762
  2. Bhattacharyya T, et al. Relationship of paraoxonase (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. J. Amer. Med. Assoc. (2008) 299(11): 1265-76.
  3. Podrez EA, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a pro-thrombotic phenotype. Nature Medicine (2007) 13:1086-1095.
  4. Wang Z, et al Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nature Medicine (2007) 13:1176-84.
  5. Wu Z, et al. The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat. Struct. Mol. Biol.  (2007) 14: 861-8.
  6. Brennan ML, et al. Prognostic value of myeloperoxidase in patients with chest pain. New Engl J Med.  (2003) 349(17):1595-604.

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